Kinesin Kif2C in regulation of DNA double strand break dynamics and repair

Autor: Songli Zhu, Mohammadjavad Paydar, Feifei Wang, Yanqiu Li, Ling Wang, Benoit Barrette, Tadayoshi Bessho, Benjamin H Kwok, Aimin Peng

Publikováno v: eLife, Vol 9 (2020)

DNA double strand breaks (DSBs) have detrimental effects on cell survival and genomic stability, and are related to cancer and other human diseases. In this study, we identified microtubule-depolymerizing kinesin Kif2C as a protein associated with DS

Externí odkaz: https://doaj.org/article/335398a307dd48f6895ff3abe516284a

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

Autor: Matthieu P.M.H. Benoit, Ana B. Asenjo, Mohammadjavad Paydar, Sabin Dhakal, Benjamin H. Kwok, Hernando Sosa

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs bound to microtubules in the presence of differen

Externí odkaz: https://doaj.org/article/69dab0e441714c2f9885f2595e096141

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells

Autor: Bernardo Orr, Lama Talje, Zhexian Liu, Benjamin H. Kwok, Duane A. Compton

Publikováno v: Cell Reports, Vol 17, Iss 7, Pp 1755-1763 (2016)

Karyotype diversity is a hallmark of solid tumors that contributes to intratumor heterogeneity. This diversity is generated by persistent chromosome mis-segregation associated with chromosomal instability (CIN). CIN correlates with tumor relapse and

Externí odkaz: https://doaj.org/article/4e063eb7fc8a47e194f8bf8f4d0b70c1

Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14

Autor: Sabin Dhakal, Benjamin H. Kwok, Matthieu P. M. H. Benoit, Mohammadjavad Paydar, Hernando Sosa, Ana B. Asenjo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Nature Communications

KIF14 is a mitotic kinesin whose malfunction is associated with cerebral and renal developmental defects and several cancers. Like other kinesins, KIF14 couples ATP hydrolysis and microtubule binding to the generation of mechanical work, but the coup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01de5cd0a857cb88cb2b08763b54079b
https://doaj.org/article/69dab0e441714c2f9885f2595e096141

Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny

Autor: Maria Osipenko, Hamid Meziane, Binnaz Yalcin, Gabrielle Rudolf, John S. Allingham, Ekaterina L. Ivanova, Maria-Victoria Hinckelmann, Loic Broix, Johan G. Gilet, Valerie Skory, Benjamin H. Kwok, Marie-Christine Birling, Jérémie Courraud, Daria Trofimova, Nathalie Drouot, Jamel Chelly, Nadia Bahi-Buisson, Paul Voulleminot

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2020, 29 (5), pp.766-784. ⟨10.1093/hmg/ddz316⟩
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (5), pp.766-784. ⟨10.1093/hmg/ddz316⟩
Hum Mol Genet

By using the Cre-mediated genetic switch technology, we were able to successfully generate a conditional knock-in mouse, bearing the KIF2A p.His321Asp missense point variant, identified in a subject with malformations of cortical development. These m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de9467df1fdd7aa1a2aebafc72ab0e8
https://www.hal.inserm.fr/inserm-02551504/file/ddz316.pdf