Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Benjamin Gibert"'
Autor:
Marie Piecyk, Mouna Triki, Pierre‐Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean‐Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro‐Peyret, Cedric Chaveroux
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2111-2135 (2024)
Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance. Here, link
Externí odkaz:
https://doaj.org/article/89467b01b1f341de9d7f3e3b189e80c0
Autor:
Pirunthan Perampalam, James I MacDonald, Komila Zakirova, Daniel T Passos, Sumaiyah Wasif, Yudith Ramos-Valdes, Maeva Hervieu, Patrick Mehlen, Rob Rottapel, Benjamin Gibert, Rohann JM Correa, Trevor G Shepherd, Frederick A Dick
Publikováno v:
eLife, Vol 12 (2024)
Dormancy in cancer is a clinical state in which residual disease remains undetectable for a prolonged duration. At a cellular level, rare cancer cells cease proliferation and survive chemotherapy and disseminate disease. We created a suspension cultu
Externí odkaz:
https://doaj.org/article/fb52aec78d484fa7a44a296e56c0db33
Autor:
David Kryza, Jennifer Wischhusen, Mathieu Richaud, Maëva Hervieu, Jacqueline Sidi Boumedine, Jean‐Guy Delcros, Sophie Besse, Thomas Baudier, Pierre‐Alexandre Laval, Silvia Breusa, Erwan Boutault, Hugo Clermidy, Nicolas Rama, Benjamin Ducarouge, Mojgan Devouassoux‐Shisheboran, Jean‐Michel Chezal, Anne‐Laure Giraudet, Thomas Walter, Patrick Mehlen, David Sarrut, Benjamin Gibert
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-13 (2023)
Abstract Targeted radionuclide therapy is a revolutionary tool for the treatment of highly spread metastatic cancers. Most current approaches rely on the use of vectors to deliver radionuclides to tumor cells, targeting membrane‐bound cancer‐spec
Externí odkaz:
https://doaj.org/article/d9f5252ceab344fca27e6ed88f83c690
Autor:
Laura Gerard, David Barthelemy, Arnaud Gauthier, Valerie Hervieu, Jonathan Lopez, Benjamin Gibert, Helene Lasolle, Laurence Chardon, Jessica Garcia, Gérald Raverot, Léa Payen, Thomas Walter
Publikováno v:
Endocrine Oncology, Vol 1, Iss 1, Pp K1-K6 (2023)
We report a case of metastatic pancreatic neuroendocrine carcinoma associated with paraneoplastic Cushing’s syndrome, successively treated with five lines of treatment (platin-etoposide, LV5FU2-dacarbazine, FOLFIRINOX, pembrolizumab, and paclitaxel
Externí odkaz:
https://doaj.org/article/c360988423ca4f5b97a7abac344f3ea5
Autor:
Shan Jiang, Mathieu Richaud, Pauline Vieugué, Nicolas Rama, Jean‐Guy Delcros, Maha Siouda, Mitsuaki Sanada, Anna‐Rita Redavid, Benjamin Ducarouge, Maëva Hervieu, Silvia Breusa, Ambroise Manceau, Charles‐Henry Gattolliat, Nicolas Gadot, Valérie Combaret, David Neves, Sandra Ortiz‐Cuaran, Pierre Saintigny, Olivier Meurette, Thomas Walter, Isabelle Janoueix‐Lerosey, Paul Hofman, Peter Mulligan, David Goldshneider, Patrick Mehlen, Benjamin Gibert
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-14 (2021)
Abstract The navigation cue netrin‐1 is well‐documented for its key role in cancer development and represents a promising therapeutic target currently under clinical investigation. Phase 1 and 2 clinical trials are ongoing with NP137, a humanized
Externí odkaz:
https://doaj.org/article/6c028dc815534fea934acb961c88b3f0
Autor:
Simon Renders, Arthur Flohr Svendsen, Jasper Panten, Nicolas Rama, Maria Maryanovich, Pia Sommerkamp, Luisa Ladel, Anna Rita Redavid, Benjamin Gibert, Seka Lazare, Benjamin Ducarouge, Katharina Schönberger, Andreas Narr, Manon Tourbez, Bertien Dethmers-Ausema, Erik Zwart, Agnes Hotz-Wagenblatt, Dachuan Zhang, Claudia Korn, Petra Zeisberger, Adriana Przybylla, Markus Sohn, Simon Mendez-Ferrer, Mathias Heikenwälder, Maik Brune, Daniel Klimmeck, Leonid Bystrykh, Paul S. Frenette, Patrick Mehlen, Gerald de Haan, Nina Cabezas-Wallscheid, Andreas Trumpp
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 prod
Externí odkaz:
https://doaj.org/article/3c2f87ae1c244f13b1b1ad0a9daad872
Autor:
Konrad Krawczyk, Tadeusz Chelkowski, Daniel J Laydon, Swapnil Mishra, Denise Xifara, Benjamin Gibert, Seth Flaxman, Thomas Mellan, Veit Schwämmle, Richard Röttger, Johannes T Hadsund, Samir Bhatt
Publikováno v:
Journal of Medical Internet Research, Vol 23, Iss 7, p e31544 (2021)
Externí odkaz:
https://doaj.org/article/4b4186db3ee84483aacef8c9be8f64c1
Autor:
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jérôme Estaquier, Germain Gillet, Isabelle Guénal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stéphen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernard Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Luc Poyet, Muriel Priault, Jean-Ehrland Ricci, Franck B. Riquet, Santos A. Susin, Magali Suzanne, Pierre Vacher, Ludivine Walter, Bertrand Mollereau
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 901 (2022)
Since the Nobel Prize award more than twenty years ago for discovering the core apoptotic pathway in C. elegans, apoptosis and various other forms of regulated cell death have been thoroughly characterized by researchers around the world. Although ma
Externí odkaz:
https://doaj.org/article/a7116fd2eb2845b5911a169d405c21e9
CDYL2 Epigenetically Regulates MIR124 to Control NF-κB/STAT3-Dependent Breast Cancer Cell Plasticity
Autor:
Maha Siouda, Audrey D. Dujardin, Laetitia Barbollat-Boutrand, Marco A. Mendoza-Parra, Benjamin Gibert, Maria Ouzounova, Jebrane Bouaoud, Laurie Tonon, Marie Robert, Jean-Philippe Foy, Vincent Lavergne, Serge N. Manie, Alain Viari, Alain Puisieux, Gabriel Ichim, Hinrich Gronemeyer, Pierre Saintigny, Peter Mulligan
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101141- (2020)
Summary: Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression but remains poorly understood. We found that the uncharacterized epigenetic factor chromodomain on Y-like 2 (CDYL2) is commonly over
Externí odkaz:
https://doaj.org/article/b54fa9709e804d8693e769f67890345e
Autor:
Shuheng Lin, Ana Negulescu, Sirisha Bulusu, Benjamin Gibert, Jean-Guy Delcros, Benjamin Ducarouge, Nicolas Rama, Nicolas Gadot, Isabelle Treilleux, Pierre Saintigny, Olivier Meurette, Patrick Mehlen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Notch signalling is deregulated in several cancers; therefore, strategies targeting this pathway are currently being explored. Here the authors report a pro-apoptotic function of Notch3 in endothelial cells; consequently, when Notch3 is silenced in s
Externí odkaz:
https://doaj.org/article/2f70525d7341492bb8bcac42457a17af