Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Benjamin Gateno"'
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Externí odkaz:
https://doaj.org/article/67f438cf2e6642df8392e5f12d364395
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Abstract Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I trigger
Externí odkaz:
https://doaj.org/article/2dbe29f2b76b4e27b72c8ee1c521260b
Autor:
Liang Zhang, Song Zhang, Izumi Maezawa, Sergey Trushin, Paras Minhas, Matthew Pinto, Lee-Way Jin, Keshar Prasain, Thi D.T. Nguyen, Yu Yamazaki, Takahisa Kanekiyo, Guojun Bu, Benjamin Gateno, Kyeong-Ok Chang, Karl A. Nath, Emirhan Nemutlu, Petras Dzeja, Yuan-Ping Pang, Duy H. Hua, Eugenia Trushina
Publikováno v:
EBioMedicine, Vol 2, Iss 4, Pp 294-305 (2015)
Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau and averts cognitive decl
Externí odkaz:
https://doaj.org/article/89446c32603a429e97abaf9d89ef71a0
Autor:
Benjamin Gateno, Tara O’Hagan, Michael K. Lee, Xiujuan Zhu, Yu Yamazaki, Joel M. Reid, Andrea Stojakovic, Takahisa Kanekiyo, Su-Youne Chang, Song Zhang, Renee A. Schoon, Tamar Pirtskhalava, Rachel E. Geroux, Xing Li, Ye In Christopher Kwon, Trace A. Christensen, Eugenia Trushina, Jeffrey L. Salisbury, Slobodan Macura, Cory C. Funk, Mrunal Dehankar, James L. Kirkland, Petras P. Dzeja, Utkarsh Tripathi, Jarred J. Nesbitt, Adam Jaspersen, Tamar Tchkonia, Padraig J. Flannery, Sergey Trushin, Emirhan Nemutlu, Jordan Wilkins, Alexander Galkin, Anna Stepanova, Anthony Sheu, Layla Khalili, Rachel A. Kudgus
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-20 (2021)
Alzheimer’s Disease (AD) is a devastating neurodegenerative disorder without a cure. Here we show that mitochondrial respiratory chain complex I is an important small molecule druggable target in AD. Partial inhibition of complex I triggers the AMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741f61f53ec406ab3442805ab137811a
http://europepmc.org/articles/PMC7794523
http://europepmc.org/articles/PMC7794523
Autor:
Tamar Pirtskhalava, Trace A. Christensen, Emirhan Nemutlu, Mrunal Dehankar, Utkarsh Tripathi, Adam Jaspersen, Anthony Sheu, Sergey Trushin, Eugenia Trushina, Tamar Tchkonia, Christopher Ye In Kwon, Su-Youne Chang, Song Zhang, James L. Kirkland, Xing Li, Xiujuan Zhu, Slobodan Macura, Jordan Wilkins, Layla Khalili, Rachel A. Kudgus, Andrea Stojakovic, Jeffrey L. Salisbury, Alexander Galkin, Jarred J. Nesbitt, Petras P. Dzeja, Padraig J. Flannery, Joel M. Reid, Renee A. Schoon, Takahisa Kanekiyo, Anna Stepanova, Tara O’Hagan, Michael K. Lee, Yu Yamazaki, Rachel E. Geroux, Cory C. Funk, Benjamin Gateno
We demonstrate that mitochondrial respiratory chain complex I is an important small molecule druggable target in Alzheimer’s Disease (AD). Partial inhibition of complex I triggers the AMP-activated protein kinase-dependent signaling network leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9277825fbc16e4b867cbddafb5528dbf
https://doi.org/10.1101/2020.07.01.182428
https://doi.org/10.1101/2020.07.01.182428
Autor:
Andrea Stojakovic, Padraig J. Flannery, Jordan Wilkins, Sergey Trushin, Eugenia Trushina, Su-Youne Chang, Utkarsh Tripathi, Benjamin Gateno
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aac171f0a8679638e4eaaf4ee77eed7
https://doi.org/10.1016/j.jalz.2018.06.037
https://doi.org/10.1016/j.jalz.2018.06.037
Autor:
Andrea Stojakovic, Sergey Trushin, Benjamin Gateno, Liang Zhang, Kevin Greenman, Olga Isaakova, Eugenia Trushina, William Guilford, Robert Greenhouse
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea46360bf8636b063f6129873f02cbe
https://doi.org/10.1016/j.jalz.2018.06.080
https://doi.org/10.1016/j.jalz.2018.06.080
Autor:
Emirhan Nemutlu, Song Zhang, Liang Zhang, Benjamin Gateno, Thi D.T. Nguyen, Takahisa Kanekiyo, Petras P. Dzeja, Izumi Maezawa, Kyeong-Ok Chang, Yuan Ping Pang, Lee-Way Jin, Keshar Prasain, Eugenia Trushina, Matthew Pinto, Yu Yamazaki, Paras S. Minhas, Guojun Bu, Sergey Trushin, Duy H. Hua, Karl A. Nath
Publikováno v:
EBioMedicine, Vol 2, Iss 4, Pp 294-305 (2015)
EBioMedicine
EBioMedicine, vol 2, iss 4
EBioMedicine
EBioMedicine, vol 2, iss 4
Development of therapeutic strategies to prevent Alzheimer's disease (AD) is of great importance. We show that mild inhibition of mitochondrial complex I with small molecule CP2 reduces levels of amyloid beta and phospho-Tau and averts cognitive decl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c76c3fc1b2065e03b39b86b0ac1bab8
Autor:
Duy H. Hua, Takahisa Kanekiyo, Petras P. Dzeja, Song Zhang, Benjamin Gateno, Matthew Pinto, Izumi Maezawa, Lee-Way Jin, Keshar Prasain, Eugenia Trushina, Yuan Ping Pang, Thi D.T. Nguyen, Liang Zhang, Paras S. Minhas, Kyeong-Ok Chang, Guojun Bu, Yu Yamazaki, Emirhan Nemutlu, Karl A. Nath, Sergey Trushin
Publikováno v:
EBioMedicine. 42:532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da5f00b6b78cb3530f95715582bda9a
https://doi.org/10.1016/j.ebiom.2019.03.062
https://doi.org/10.1016/j.ebiom.2019.03.062
Autor:
Emily R. Patterson, Wayne W. Poon, Jeffrey L. Salisbury, Karen H. Gylys, Benjamin Gateno, Kie Itoh, Roberta Diaz Brinton, Joseph E. Parisi, Eugenia Trushina, Hiromi Sesaki, Sergey Trushin, Trace A. Christensen, Andreas S. Schroeder, Liang Zhang, Benjamin V. Bachmeier, Jia Yao
Publikováno v:
Scientific Reports
Altered brain metabolism is associated with progression of Alzheimer’s Disease (AD). Mitochondria respond to bioenergetic changes by continuous fission and fusion. To account for three dimensional architecture of the brain tissue and organelles, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c8e14a927f52074136fc46e944da8e