Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Benjamin G, Bitler"'
Autor:
Julia M. Dexter, Lindsay W. Brubaker, Benjamin G. Bitler, Barbara A. Goff, Usha Menon, Katherine N. Moore, Karthik M. Sundaram, Christine S. Walsh, Saketh R. Guntupalli, Kian Behbakht
Publikováno v:
Gynecologic Oncology Reports, Vol 53, Iss , Pp 101376- (2024)
Early diagnosis and screening of ovarian cancer remain significant challenges to improving patient outcomes. There is an urgent need to implement both established and modern strategies to address the “early detection” conundrum, especially as new
Externí odkaz:
https://doaj.org/article/c74da8990e0e49619399034ef680a016
SMASH: Scalable Method for Analyzing Spatial Heterogeneity of genes in spatial transcriptomics data.
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010983 (2023)
In high-throughput spatial transcriptomics (ST) studies, it is of great interest to identify the genes whose level of expression in a tissue covaries with the spatial location of cells/spots. Such genes, also known as spatially variable genes (SVGs),
Externí odkaz:
https://doaj.org/article/dadb900a561f4c84983f74df3fd4b21a
Autor:
Mansooreh Ahmadian, Christian Rickert, Angela Minic, Julia Wrobel, Benjamin G Bitler, Fuyong Xing, Michael Angelo, Elena W Y Hsieh, Debashis Ghosh, Kimberly R Jordan
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 9, p e1011432 (2023)
Multiplex imaging is a powerful tool to analyze the structural and functional states of cells in their morphological and pathological contexts. However, hypothesis testing with multiplex imaging data is a challenging task due to the extent and comple
Externí odkaz:
https://doaj.org/article/e7584e9180f24e198429145c9540321c
Autor:
Souvik Seal, Julia Wrobel, Amber M. Johnson, Raphael A. Nemenoff, Erin L. Schenk, Benjamin G. Bitler, Kimberly R. Jordan, Debashis Ghosh
Publikováno v:
BMC Research Notes, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Objective Multiplex immunohistochemistry (mIHC) and multiplexed ion beam imaging (MIBI) images are usually phenotyped using a manual thresholding process. The thresholding is prone to biases, especially when examining multiple images with hi
Externí odkaz:
https://doaj.org/article/e2bb3bed4c90455c8b26d8395e5e72ae
Autor:
Brooke E. Sanders, Rebecca Wolsky, Elizabeth S. Doughty, Kristen L. Wells, Debashis Ghosh, Lisa Ku, Joseph G. Pressey, Benjamin G. Bitler, Lindsay W. Brubaker
Publikováno v:
Gynecologic Oncology Reports, Vol 44, Iss , Pp 101077- (2022)
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT) is a rare and aggressive disease. While classically linked to mutations in SMARCA4, we describe a case in a patient with both SMARCA4 and BRCA2 germline mutations. We describe her disease
Externí odkaz:
https://doaj.org/article/f380137562bb40169ca67c2ddb43c677
Publikováno v:
Heliyon, Vol 8, Iss 10, Pp e10862- (2022)
Claudin-4, a protein with the structure of classic claudins most often found in cell-cell junctions, is frequently overexpressed in epithelial cancers where its localization has not been studied. In this study we aimed to find out where this membrane
Externí odkaz:
https://doaj.org/article/a41d0d5f72c1467789792a7d3777359f
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1009486 (2022)
The tumor microenvironment (TME), which characterizes the tumor and its surroundings, plays a critical role in understanding cancer development and progression. Recent advances in imaging techniques enable researchers to study spatial structure of th
Externí odkaz:
https://doaj.org/article/2da67b122ace40e1a43f67a3f0acf3d9
Autor:
Lindsay W. Brubaker, Donald S. Backos, Vu T. Nguyen, Philip Reigan, Tomomi M Yamamoto, Elizabeth R. Woodruff, Ritsuko Iwanaga, Michael F. Wempe, Vijay Kumar, Christianne Persenaire, Zachary L. Watson, Benjamin G. Bitler
Publikováno v:
Expert Opinion on Therapeutic Targets. :1-11
Publikováno v:
Technology in Cancer Research & Treatment, Vol 20 (2021)
The clinical use of molecular tumor profiling (MTP) is expanding and there is an increasing use of MTP data to manage patient care. At the University of Colorado, 18 patients were diagnosed with primary serous ovarian cancer between 9/2015 and 6/2019
Externí odkaz:
https://doaj.org/article/693bae7f80d040c48fbe0d06f4adc8a9
Autor:
Lindsay J. Wheeler, Zachary L. Watson, Lubna Qamar, Tomomi M. Yamamoto, Brandon T. Sawyer, Kelly D. Sullivan, Santosh Khanal, Molishree Joshi, Veronique Ferchaud-Roucher, Harry Smith, Lauren A. Vanderlinden, Sky W. Brubaker, Cecilia M. Caino, Hyunmin Kim, Joaquin M. Espinosa, Jennifer K. Richer, Benjamin G. Bitler
Publikováno v:
iScience, Vol 19, Iss , Pp 474-491 (2019)
Summary: High-grade serous ovarian cancers (HGSOCs) arise from exfoliation of transformed cells from the fallopian tube, indicating that survival in suspension, and potentially escape from anoikis, is required for dissemination. We report here the re
Externí odkaz:
https://doaj.org/article/d7cae58c70cf4b989ef74c7cfa5a6c7f