Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Benjamin E Tourdot"'
Autor:
Adriana Yamaguchi, Christopher vanHoorebeke, Benjamin E. Tourdot, Steven C. Perry, Grace Lee, Nicole Rhoads, Andrew Rickenberg, Abigail R. Green, James Sorrentino, Jennifer Yeung, J. Cody Freedman, Theodore R. Holman, Michael Holinstat
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15‐LOX‐derived meta
Externí odkaz:
https://doaj.org/article/59a65c3dbd9846fcb9d48b2c506a8e61
Autor:
Steven C. Perry, Chakrapani Kalyanaraman, Benjamin E. Tourdot, William S. Conrad, Oluwayomi Akinkugbe, John Cody Freedman, Michael Holinstat, Matthew P. Jacobson, Theodore R. Holman
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 1087-1103 (2020)
The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs). The
Externí odkaz:
https://doaj.org/article/7347b4f4bdff49a38d8406855c419d2c
Autor:
Benjamin E. Tourdot, Reheman Adili, Zitha R. Isingizwe, Meral Ebrahem, J. Cody Freedman, Theodore R. Holman, Michael Holinstat
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 1124-1131 (2017)
Abstract: The dihomo-γ-linolenic acid (DGLA)–derived metabolite of 12-lipoxygenase, 12-hydroxy-eicosatrienoic acid (12-HETrE), was recently shown to potently inhibit thrombus formation without prolonging bleeding in murine models. Although 12-HETr
Externí odkaz:
https://doaj.org/article/0216b0e948b94426ad8530ece9a0043b
Autor:
Donald R. Lynch, Emily N. Stringham, Boya Zhang, Ginette Balbin-Cuesta, Brian R. Curtis, Joseph S. Palumbo, Colin F. Greineder, Benjamin E. Tourdot
Publikováno v:
Blood Advances. 6:4645-4656
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)–mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17c278eeaab7be39df7a72080bde77
https://doi.org/10.1182/bloodadvances.2022007195
https://doi.org/10.1182/bloodadvances.2022007195
Publikováno v:
Current Protocols. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a8f0a5b8366f3dc7cc4e2a6566567ed
https://doi.org/10.1002/cpz1.668
https://doi.org/10.1002/cpz1.668
Publikováno v:
Circ Res
The association between inflammation, infection, and venous thrombosis has long been recognized; yet, only in the last decades have we begun to understand the mechanisms through which the immune and coagulation systems interact and reciprocally regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8070b6d07f77d12a334a035a420a8d
https://doi.org/10.1161/circresaha.121.318225
https://doi.org/10.1161/circresaha.121.318225
Autor:
Peter Busch-Østergren, Shivam Patel, Samuel Jaimian Church, Thomas W. Wakefield, Mackenzie Adams, James Henderson, Benjamin E. Tourdot, Adriana Yamaguchi, Tadas Kasputis, Ajjai Alva, Michael Holinstat, Aaron M. Udager, Zachery R. Reichert, Xiu Cao, Ganesh S. Palapattu, Alexander Zaslavsky, Samantha K. Lee, Sydney Ohl, Todd M. Morgan, Sethuramasundaram Pitchiaya
Publikováno v:
Thromb Res
INTRODUCTION: Despite the great promise for therapies using antisense oligonucleotides (ASOs), their adverse effects, which include pro-inflammatory effects and thrombocytopenia, have limited their use. Previously, these effects have been linked to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52700eb72ef5d723c1e5334310aebfd4
https://doi.org/10.1016/j.thromres.2021.01.006
https://doi.org/10.1016/j.thromres.2021.01.006
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 41
Cardiovascular disease is the leading cause of mortality in the US annually. The underlying cause of mortality in cardiovascular disease is the formation of platelet-rich clots that occlude blood vessels due to aberrant platelet activation. While ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f60012dab91e0ce7941810cb77092856
https://doi.org/10.1161/atvb.41.suppl_1.p119
https://doi.org/10.1161/atvb.41.suppl_1.p119
Autor:
Michael Holinstat, Anuli C. Anyanwu, Raymond Zhao, J. Michelle Kahlenberg, Sharon Koonse, Hui Liao, Yogendra Kanthi, Benjamin E. Tourdot, Benjamin N. Jacobs, Scott H. Visovatti, Srilakshmi Yalavarthi, Alison L. Banka, Liguo Chi, Vinita Yadav, David J. Pinsky, Jason S. Knight
Publikováno v:
Journal of Clinical Investigation. 129:2872-2877
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of evidence ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bcbeee03e13e4f5227c3ef48e4d2090
https://doi.org/10.1172/jci124804
https://doi.org/10.1172/jci124804
Autor:
Benjamin E. Tourdot, Theodore R. Holman, Matthew P. Jacobson, William S. Conrad, Steve Perry, Oluwayomi Akinkugbe, Chakrapani Kalyanaraman, Michael Holinstat, Adriana Yamaguchi, Thomas Horn
Publikováno v:
Biochemistry
Biochemistry, vol 59, iss 42
Biochemistry, vol 59, iss 42
The oxylipins, 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid (5S,12S-diHETE) and 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid (5S,15S-diHETE), have been identified in cell exudates and have chemotactic activity toward eosinophils and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098026d42104a9588af083e7be6be279
https://pubmed.ncbi.nlm.nih.gov/33048542
https://pubmed.ncbi.nlm.nih.gov/33048542