Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Benjamin E Low"'
Autor:
Amandine Jarysta, Abigail LD Tadenev, Matthew Day, Barry Krawchuk, Benjamin E Low, Michael V Wiles, Basile Tarchini
Publikováno v:
eLife, Vol 12 (2024)
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all G
Externí odkaz:
https://doaj.org/article/ec7caf9da44543fb990c83c4cfecfffe
Autor:
Thomas J Sproule, Robert Y Wilpan, John J Wilson, Benjamin E Low, Yudai Kabata, Tatsuo Ushiki, Riichiro Abe, Michael V Wiles, Derry C Roopenian, John P Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293218 (2023)
The Lamc2jeb junctional epidermolysis bullosa (EB) mouse model has been used to demonstrate that significant genetic modification of EB symptoms is possible, identifying as modifiers Col17a1 and six other quantitative trait loci, several with strong
Externí odkaz:
https://doaj.org/article/658a1999797249b9a32a5a0a6180cfda
Autor:
Thomas J Sproule, Robert Y Wilpan, Benjamin E Low, Kathleen A Silva, Deepak Reyon, J Keith Joung, Michael V Wiles, Derry C Roopenian, John P Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292456 (2023)
Previous work strongly implicated Collagen 17a1 (Col17a1) as a potent genetic modifier of junctional epidermolysis bullosa (JEB) caused by a hypomorphic mutation (Lamc2jeb) in mice. The importance of the noncollagenous domain (NC4) of COLXVII was sug
Externí odkaz:
https://doaj.org/article/678e25f859e64d80a1b1744863c9b5d2
Autor:
Robert A Taft, Benjamin E Low, Shannon L Byers, Stephen A Murray, Peter Kutny, Michael V Wiles
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67826 (2013)
There is a continual need to improve efficiency in creating precise genetic modifications in mice using embryonic stem cells (ESCs). We describe a novel approach resulting in 100% germline transmission from competent injected ESCs. We developed an F1
Externí odkaz:
https://doaj.org/article/0fb319c35da548dc9a430f4682cf6fd0
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The development of mouse models of human disease and synthetic biology research by targeted transgenesis of large DNA constructs represent a significant genetic engineering hurdle. We developed an efficient, precise, single-copy integration
Externí odkaz:
https://doaj.org/article/5f22cb85ab5f473c9c26982747cd84dc
Autor:
Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the s
Externí odkaz:
https://doaj.org/article/4542729f114f4a1997e48e7b8d00f056
Autor:
Amandine Jarysta, Abigail L.D. Tadenev, Matthew Day, Barry Krawchuk, Benjamin E. Low, Michael V. Wiles, Basile Tarchini
Publikováno v:
bioRxiv
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798ad24f5a1eb886d0173266d04eab35
https://doi.org/10.1101/2023.05.25.542257
https://doi.org/10.1101/2023.05.25.542257
Autor:
Kyuson Yun, Mark A. Israel, Leonard D. Shultz, Roderick T. Bronson, Abhijit Guha, Joydeep Mukherje, Benjamin E. Low, Hyuna Yang, Molly A. Harris
The recent identification of cancer stem cells (CSCs) in multiple human cancers provides a new inroad to understanding tumorigenesis at the cellular level. CSCs are defined by their characteristics of self-renewal, multipotentiality, and tumor initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3ffb337f2847a0b8d1fa316eb74926
https://doi.org/10.1158/0008-5472.c.6497853
https://doi.org/10.1158/0008-5472.c.6497853
Autor:
Kyuson Yun, Mark A. Israel, Leonard D. Shultz, Roderick T. Bronson, Abhijit Guha, Joydeep Mukherje, Benjamin E. Low, Hyuna Yang, Molly A. Harris
Supplementary Figure 3 from Cancer Stem Cells Are Enriched in the Side Population Cells in a Mouse Model of Glioma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139ba807f535865b0bcf64e09cf30795
https://doi.org/10.1158/0008-5472.22375506.v1
https://doi.org/10.1158/0008-5472.22375506.v1
Autor:
Kyuson Yun, Michael D. Taylor, Roderick T. Bronson, Brad Rybinski, Vivek Philip, Benjamin E. Low, Seungbum Choi, David J. Shih, Emily E. Miller, Molly H. Jenkins, Dong-Mi Shin, Kin-Hoe Chow
Supplementary Figure Legends from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1123c741dd415e486e2c98d4883b36bb
https://doi.org/10.1158/0008-5472.22400676
https://doi.org/10.1158/0008-5472.22400676