Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Benjamin E Low"'
Autor:
Amandine Jarysta, Abigail LD Tadenev, Matthew Day, Barry Krawchuk, Benjamin E Low, Michael V Wiles, Basile Tarchini
Publikováno v:
eLife, Vol 12 (2024)
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all G
Externí odkaz:
https://doaj.org/article/ec7caf9da44543fb990c83c4cfecfffe
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The development of mouse models of human disease and synthetic biology research by targeted transgenesis of large DNA constructs represent a significant genetic engineering hurdle. We developed an efficient, precise, single-copy integration
Externí odkaz:
https://doaj.org/article/5f22cb85ab5f473c9c26982747cd84dc
Autor:
Thomas J Sproule, Robert Y Wilpan, John J Wilson, Benjamin E Low, Yudai Kabata, Tatsuo Ushiki, Riichiro Abe, Michael V Wiles, Derry C Roopenian, John P Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0293218 (2023)
The Lamc2jeb junctional epidermolysis bullosa (EB) mouse model has been used to demonstrate that significant genetic modification of EB symptoms is possible, identifying as modifiers Col17a1 and six other quantitative trait loci, several with strong
Externí odkaz:
https://doaj.org/article/658a1999797249b9a32a5a0a6180cfda
Autor:
Thomas J Sproule, Robert Y Wilpan, Benjamin E Low, Kathleen A Silva, Deepak Reyon, J Keith Joung, Michael V Wiles, Derry C Roopenian, John P Sundberg
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292456 (2023)
Previous work strongly implicated Collagen 17a1 (Col17a1) as a potent genetic modifier of junctional epidermolysis bullosa (JEB) caused by a hypomorphic mutation (Lamc2jeb) in mice. The importance of the noncollagenous domain (NC4) of COLXVII was sug
Externí odkaz:
https://doaj.org/article/678e25f859e64d80a1b1744863c9b5d2
Autor:
Jennifer K. Sargent, Mark A. Warner, Benjamin E. Low, William H. Schott, Todd Hoffert, David Coleman, Xing Yi Woo, Todd Sheridan, Sonia Erattupuzha, Philipp P. Henrich, Vivek M. Philip, Jeffrey H. Chuang, Michael V. Wiles, Muneer G. Hasham
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/cd0b8ed3add94265be8d44e04d45e0f5
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/3aa63b687fae4633a049c778577a87f7
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The inability to insert large DNA constructs into the genome efficiently and precisely is a key challenge in genomic engineering. Random transgenesis, which is widely used, lacks precision, and comes with a slew of drawbacks. Lentiviral and adeno-ass
Externí odkaz:
https://doaj.org/article/646a1d7039ed4d209202d2d1ea981c43
Autor:
Vishnu Hosur, Benjamin E. Low, Daniel Li, Grace A. Stafford, Vivek Kohar, Leonard D. Shultz, Michael V. Wiles
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Background Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the s
Externí odkaz:
https://doaj.org/article/4542729f114f4a1997e48e7b8d00f056
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior. Engagement of FCGRT with the crystall
Externí odkaz:
https://doaj.org/article/5aa92fa88344437d8a2364087366b7cf
Autor:
Amandine Jarysta, Abigail L.D. Tadenev, Matthew Day, Barry Krawchuk, Benjamin E. Low, Michael V. Wiles, Basile Tarchini
Publikováno v:
bioRxiv
Inhibitory G alpha (GNAI or Gαi) proteins are critical for the polarized morphogenesis of sensory hair cells and for hearing. The extent and nature of their actual contributions remains unclear, however, as previous studies did not investigate all G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798ad24f5a1eb886d0173266d04eab35
https://doi.org/10.1101/2023.05.25.542257
https://doi.org/10.1101/2023.05.25.542257