Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 G93A Mice

Autor: Rebecca San Gil, Benjamin E. Clarke, Heath Ecroyd, Bernadett Kalmar, Linda Greensmith

Publikováno v: Cells, Vol 10, Iss 5, p 1257 (2021)

Heterogeneity of glia in different CNS regions may contribute to the selective vulnerability of neuronal populations in neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS). Here, we explored regional variations in the expression

Externí odkaz: https://doaj.org/article/79e517f5cee24ee49b3852bffbf26007

The role of astrocytes in prion-like mechanisms of neurodegeneration

Autor: Phillip Smethurst, Hannah Franklin, Benjamin E Clarke, Katie Sidle, Rickie Patani

Publikováno v: Brain. 145:17-26

Accumulating evidence suggests that neurodegenerative diseases are not merely neuronal in nature but comprise multicellular involvement, with astrocytes emerging as key players. The pathomechanisms of several neurodegenerative diseases involve the de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e50e64da764242df8924a2b9f624de
https://doi.org/10.1093/brain/awab366

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Autor: Doaa M Taha, Benjamin E Clarke, Claire E Hall, Giulia E Tyzack, Oliver J Ziff, Linda Greensmith, Bernadett Kalmar, Mhoriam Ahmed, Aftab Alam, Eric P Thelin, Nuria Marco Garcia, Adel Helmy, Christopher R Sibley, Rickie Patani

Publikováno v: Taha, D, Clarke, B, Hall, C, Tyzack, G, Ziff, O, Greensmith, L, Kalmar, B, Ahmed, M, Alam, A, Thelin, E P, Garcia, N, Helmy, A, Sibley, C R & Patani, R 2022, ' Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis ', Brain, vol. 145, no. 2, pp. 481-489 . https://doi.org/10.1093/brain/awab328

Amyotrophic lateral sclerosis is a rapidly progressive and fatal disease. Although astrocytes are increasingly recognized contributors to the underlying pathogenesis, the cellular autonomy and uniformity of astrocyte reactive transformation in differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c63121cb13970e6ca055888c04649a
https://www.pure.ed.ac.uk/ws/files/251644449/awab328.pdf

Meta-analysis of human and mouse ALS astrocytes reveals multi-omic signatures of inflammatory reactive states

Autor: Oliver J. Ziff, Benjamin E. Clarke, Doaa M. Taha, Hamish Crerar, Nicholas M. Luscombe, Rickie Patani

Publikováno v: Genome Res

Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but whether they adopt deleterious features consistent with inflammatory reactive states remains incompletely resolved. To identify inflammatory reactive features in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d430655ba298ee365724b102107d5743
https://pubmed.ncbi.nlm.nih.gov/34963663

Reactive astrocytes in ALS display diminished intron retention

Autor: Oliver J. Ziff, Jacob Neeves, Anob M. Chakrabarti, Nicholas M. Luscombe, Gavin Kelly, Benjamin E. Clarke, Doaa M Taha, Rickie Patani, Hamish Crerar, Giulia E. Tyzack

Publikováno v: Nucleic Acids Research

Reactive astrocytes are implicated in amyotrophic lateral sclerosis (ALS), although the mechanisms controlling reactive transformation are unknown. We show that decreased intron retention (IR) is common to human-induced pluripotent stem cell (hiPSC)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ee90c7dcbd1e349e0b96f603703960
https://pubmed.ncbi.nlm.nih.gov/33684213