Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Autor: Sofia Ferreira-Gonzalez, Wei-Yu Lu, Alexander Raven, Benjamin Dwyer, Tak Yung Man, Eoghan O’Duibhir, Philip J. Starkey Lewis, Lara Campana, Tim J. Kendall, Thomas G. Bird, Nuria Tarrats, Juan-Carlos Acosta, Luke Boulter, Stuart J. Forbes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Senescence has been suggested as causing biliary cholangiopathies but how this is regulated is unclear. Here, the authors generate a mouse model of biliary senescence by deleting Mdm2 in bile ducts and show that inhibiting TGFβ limits senescence-dep

Externí odkaz: https://doaj.org/article/fec37437098140028922b5a6d61c5040

Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage

Autor: Sofia Ferreira-Gonzalez, Tak Yung Man, Hannah Esser, Rhona Aird, Alastair M. Kilpatrick, Daniel Rodrigo-Torres, Nicholas Younger, Lara Campana, Victoria L. Gadd, Benjamin Dwyer, Niya Aleksieva, Luke Boulter, Mark T. Macmillan, Yinmiao Wang, Katie J. Mylonas, David A. Ferenbach, Timothy J. Kendall, Wei-Yu Lu, Juan Carlos Acosta, Dominic Kurian, Stephen O’Neill, Gabriel C. Oniscu, Jesus M. Banales, Paul J. Krimpenfort, Stuart J. Forbes

Publikováno v: Ferreira-Gonzalez, S, Man, T Y, Esser, H, Aird, R, Kilpatrick, A, Rodrigo Torres, D, Younger, N, Campana, L, Gadd, V, Dwyer, B, Aleksieva, N, Boulter, L, Macmillan, M, Wang, Y, Mylonas, K J, Ferenbach, D A, Kendall, T J, Lu, W-Y, Acosta, J C, Kurian, D, O'Neill, S, Oniscu, G, Banales, J M, Krimpenfort, P & Forbes, S J 2022, ' Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage ', Science Translational Medicine, vol. 14, no. 674, eabj4375 . https://doi.org/10.1126/scitranslmed.abj4375

Liver transplantation is the only curative option for patients with end-stage liver disease. Despite improvements in surgical techniques, nonanastomotic strictures (characterized by the progressive loss of biliary tract architecture) continue to occu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511d4735d36e8e39daf53ab681bc8df9
https://doi.org/10.1126/scitranslmed.abj4375

Constellations : The Life and Music of John Buckley

Autor: Benjamin Dwyer

As well as providing a very readable and comprehensive study of the life and music of John Buckley,　Constellations also offers an up-to-date and informative catalogue of compositions, a complete discography, translations of set texts and the full l

Insulin Production and Resistance in Different Models of Diet-Induced Obesity and Metabolic Syndrome

Autor: Ramadori, Salamah Alwahsh, Benjamin Dwyer, Shareen Forbes, David Van Thiel, Philip Starkey Lewis, Giuliano

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 2; Pages: 285

The role of the liver and the endocrine pancreas in development of hyperinsulinemia in different types of obesity remains unclear. Sedentary rats (160 g) were fed a low-fat-diet (LFD, chow 13% kcal fat), high-fat-diet (HFD, 35% fat), or HFD+ 30% etha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::c59265695704e5c99f9ac2662d83409e

Digital Documentation and the Archaeology of the Lower Pecos Canyonlands

Autor: Christopher Goodmaster, Amanda M. Castañeda, Angel Johnson, Carolyn Boyd, Francisco Marcos Marín, Benjamin Dwyer

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
Virtual Archaeology Review, Vol 3, Iss 5, Pp 98-103 (2012)

[EN] The Lower Pecos Canyonlands of southwest Texas and northern Mexico house some of the most complex and compositionally intricate prehistoric rock art in the world. Because of the unique nature and the incomparable richness of this cultural legacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf13a8720f0a8bccbb71ed3bc063a718
http://hdl.handle.net/10251/139354