Výsledky vyhledávání - "Benjamin Drew Rockett"

Akademický článek

Fish oil increases raft size and membrane order of B cells accompanied by differential effects on function

Autor: Benjamin Drew Rockett, Heather Teague, Mitchel Harris, Mark Melton, Justin Williams, Stephen R. Wassall, Saame Raza Shaikh

Publikováno v: Journal of Lipid Research, Vol 53, Iss 4, Pp 674-685 (2012)

Fish oil (FO) targets lipid microdomain organization to suppress T-cell and macrophage function; however, little is known about this relationship with B cells, especially at the animal level. We previously established that a high FO dose diminished m

Externí odkaz: https://doaj.org/article/47cccc12b46c4212958327549d8ec860

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Akademický článek

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

Autor: Benjamin Drew Rockett, Muhammad Salameh, Kristen Carraway, Kaitlin Morrison, Saame Raza Shaikh

Publikováno v: Journal of Lipid Research, Vol 51, Iss 6, Pp 1284-1297 (2010)

n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid composition; however, the relationship between n-3 PUFA and B-cell activation is unknown. Here we tested this relationship in vitro and ex vivo by measuring

Externí odkaz: https://doaj.org/article/2dead4050b2d4b869c9285aeea9f74ef

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Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids

Autor: Benjamin Drew Rockett, Mitchel Harris, Heather Teague, Saame Raza Shaikh, David Brown

Publikováno v: Immunology. 139:386-394

Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are bioactive n-3 long-chain polyunsaturated fatty acids (LCPUFAs) in fish oil that exert immunosuppressive effects. A significant amount of literature shows that n-3 LCPUFAs suppress dendrit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57428e4e3fc49b72f1fcb0804f1ab2aa
https://doi.org/10.1111/imm.12088

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Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

Autor: Benjamin Drew Rockett, Stephen R. Wassall, Shawn E. Batten, Justin A. Williams, Mitchel Harris, William Stillwell, Saame Raza Shaikh

Publikováno v: Biophysical Journal. 103(2):228-237

Omega-3 polyunsaturated fatty acids (n-3 PUFA), enriched in fish oils, are increasingly recognized to have potential benefits for treating many human afflictions. Despite the importance of PUFA, their molecular mechanism of action remains unclear. On

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbaaa2d8526fcf50adb830efcda2dfc

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High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice

Autor: Benjamin Drew Rockett, Mitchel Harris, Saame Raza Shaikh

Publikováno v: Prostaglandins, Leukotrienes and Essential Fatty Acids. 86:137-140

n-3 Polyunsaturated fatty acids (PUFA) are increasingly consumed as food additives and supplements; however, the side effects of these fatty acids, especially at high doses, remain unclear. We previously discovered a high fat n-3 PUFA diet made of fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfa8e84546b98078786a27d91851269
https://doi.org/10.1016/j.plefa.2011.12.001

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Membrane Raft Organization Is More Sensitive to Disruption by (n-3) PUFA Than Nonraft Organization in EL4 and B Cells

Autor: Saame Raza Shaikh, Alexis Rockett, Mitchel Harris, Benjamin Drew Rockett, Heather Teague, Andrew J. Franklin

Publikováno v: The Journal of Nutrition. 141:1041-1048

Model membrane and cellular detergent extraction studies show (n-3) PUFA predominately incorporate into nonrafts; thus, we hypothesized (n-3) PUFA could disrupt nonraft organization. The first objective of this study was to determine whether (n-3) PU

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4778630a8c546c0af1e6d71ee6ea9453
https://doi.org/10.3945/jn.111.138750

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Fish oil disrupts MHC class II lateral organization on the B-cell side of the immunological synapse independent of B-T cell adhesion

Autor: Lance C. Bridges, Mitchel Harris, Benjamin Drew Rockett, Mark Melton, Saame Raza Shaikh

Fish oil-enriched long chain n-3 polyunsaturated fatty acids disrupt the molecular organization of T-cell proteins in the immunological synapse. The impact of fish oil derived n-3 fatty acids on antigen-presenting cells, particularly at the animal le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c889d36e94a1f546efe39c25f886d0b
https://europepmc.org/articles/PMC3785547/

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