Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benjamin Draper"'
Autor:
Benjamin Draper, Chantelle Bowers, Eleni Vassalou, Ailsa Greppi, John Anderson, Nabil Ahmed, Michael D. Taylor, Laura K. Donovan
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103078- (2024)
Summary: Here, we present a protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models of primary, metastatic, and recurrent brain tumors. We provide instructions for isolating peripheral blood mon
Externí odkaz:
https://doaj.org/article/dc2222e4f824449c93ce23541c00e4e0
Autor:
Xin Li, Lohra Mickelle Miller, Matthew Chrzanowski, Jiahe Tian, Martin F. Jarrold, Roland W. Herzog, Weidong Xiao, Benjamin Draper, Junping Zhang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Genetic engineering advances have led to recombinant adeno-associated virus (rAAV) becoming an invaluable tool for the development of effective gene therapies. The production of rAAV is susceptible to off-target heterogeneous packaging, the effects o
Externí odkaz:
https://doaj.org/article/b644a5a27ba2402b86be15f164c43ac0
Autor:
Alberto Gabizon, Hilary Shmeeda, Benjamin Draper, Ana Parente-Pereira, John Maher, Amaia Carrascal-Miniño, Rafael T. M. de Rosales, Ninh M. La-Beck
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2606 (2023)
Encapsulation of Doxorubicin (Dox), a potent cytotoxic agent and immunogenic cell death inducer, in pegylated (Stealth) liposomes, is well known to have major pharmacologic advantages over treatment with free Dox. Reformulation of alendronate (Ald),
Externí odkaz:
https://doaj.org/article/e363bd6344c14088aaee1897c4370011
Autor:
Daniel Larcombe-Young, Lynsey Whilding, David Marc Davies, Benjamin Draper, Natasha Bechman, John Maher
Publikováno v:
Larcombe-Young, D, Whilding, L, Davies, D, Draper, B, Bechman, N & Maher, J 2022, ' Generation of human parallel chimeric antigen receptor (pCAR) T cells to achieve synergistic T cell co-stimulation ', STAR Protocols, vol. 3, no. 2, 101414 . https://doi.org/10.1016/j.xpro.2022.101414
Dual co-stimulation may be harnessed using parallel chimeric antigen receptors(pCARs) in which two distinct co-stimulatory units are adjacently localized onthe plasma membrane. This protocol summarizes construct design, human Tcell isolation, retrovi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a49620be0056013455709d7ef2b0ff
https://kclpure.kcl.ac.uk/ws/files/175763017/Generation_of_human_parallel_LARCOMBE_YOUNG_Publishedonline27May2022_GOLD_VoR_CC_BY.pdf
https://kclpure.kcl.ac.uk/ws/files/175763017/Generation_of_human_parallel_LARCOMBE_YOUNG_Publishedonline27May2022_GOLD_VoR_CC_BY.pdf
Autor:
Leena Halim, Antonella Adami, Balázs Győrffy, Lynsey M. Whilding, Benjamin Draper, Ana C. Parente-Pereira, Domenico Cozzetto, Chung-Yang Ricardo Joseph, Helge Roider, Chelsea A. Taylor, Jana Obajdin, Holger Hess-Stumpp, Jinger Xie, Ayesha Iqbal, Richard Beatson, Tomasz Zabinski, Fred Aswad, John Maher, Tom Hardiman, Jelmar Quist, Anette Sommer, Caroline M. Hull, Andrew Tutt, Daniela Achkova, Kim Ngan Luu Hoang, David M. Davies, Rafael Torres Martin de Rosales, Anita Grigoriadis, Francis Man
Publikováno v:
SSRN Electronic Journal.
Despite their role in cancer surveillance, adoptive immunotherapy using γδ T-cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating γδ T-cells were expanded in serum-free medium containing TGF-β1 and IL-2 (γδ[T
Autor:
Tamara Muliaditan, Leena Halim, Lynsey May Whilding, Benjamin Draper, Daniela Yordanova Achkova, Fahima Kausar, Maya Glover, Natasha Bechman, Appitha Arulappu, Jenifer Sanchez, Kristina Grigoriadis, Kushal Kumar Das, Andrea Candelli, Daniel Larcombe-Young, Caroline Malai Hull, Richard Buus, Peter Gordon, Anita Grigoriadis, David Marc Davies, Anna Schurich, John Maher
Publikováno v:
SSRN Electronic Journal.
Autor:
Richard E. Beatson, Ana C. Parente-Pereira, Leena Halim, Domenico Cozzetto, Caroline Hull, Lynsey M. Whilding, Olivier Martinez, Chelsea A. Taylor, Jana Obajdin, Kim Ngan Luu Hoang, Benjamin Draper, Ayesha Iqbal, Tom Hardiman, Tomasz Zabinski, Francis Man, Rafael T.M. de Rosales, Jinger Xie, Fred Aswad, Daniela Achkova, Chung-Yang Ricardo Joseph, Sara Ciprut, Antonella Adami, Helge G. Roider, Holger Hess-Stumpp, Balázs Győrffy, Jelmar Quist, Anita Grigoriadis, Anette Sommer, Andrew N.J. Tutt, David M. Davies, John Maher
Publikováno v:
Cell Reports Medicine
Summary Despite its role in cancer surveillance, adoptive immunotherapy using γδ T cells has achieved limited efficacy. To enhance trafficking to bone marrow, circulating Vγ9Vδ2 T cells are expanded in serum-free medium containing TGF-β1 and IL-
Autor:
Francis, Man, Lindsay, Lim, Alessia, Volpe, Alberto, Gabizon, Hilary, Shmeeda, Benjamin, Draper, Ana C, Parente-Pereira, John, Maher, Philip J, Blower, Gilbert O, Fruhwirth, Rafael, T M de Rosales
Publikováno v:
Molecular Therapy
Gammadelta T (γδ-T) cells are strong candidates for adoptive immunotherapy in oncology due to their cytotoxicity, ease of expansion, and favorable safety profile. The development of γδ-T cell therapies would benefit from non-invasive cell-trackin
Autor:
Paul Maciocia, Kwee Yong, Manuel Rodriguez-Justo, Dominic Patel, Shimobi Onuoha, Simon Thomas, Martin Pule, Reyisa Bughda, Daria Galas-Filipowicz, Margarida Neves, Melody Chin, Brian Philip, Eva Kokalaki, Lydia Lee, Vania Baldan, James Francis, Benjamin Draper, Neil Chaplin
B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma (MM), but expression is variable, and early reports of BCMA targeting chimeric antigen receptors (CARs) suggest antigen downregulation at relapse. Dual-antigen ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5369fc571019d2d8485611c849aa118
https://europepmc.org/articles/PMC5922275/
https://europepmc.org/articles/PMC5922275/
Autor:
David M. Davies, Benjamin Draper, Lynsey M. Whilding, Tomasz Zabinski, Leena Halim, Ana C. Parente-Pereira, John Maher
Publikováno v:
Cancers
Volume 11
Issue 5
Whilding, L M, Halim, L, Draper, B, Parente-Pereira, A C, Zabinski, T, Davies, D M & Maher, J 2019, ' CAR T-cells targeting the integrin αvβ6 and co-expressing the chemokine receptor CXCR2 demonstrate enhanced homing and efficacy against several solid malignancies ', Cancers, vol. 11, no. 5, 674, pp. 1-17 . https://doi.org/10.3390/cancers11050674
Cancers, Vol 11, Iss 5, p 674 (2019)
Volume 11
Issue 5
Whilding, L M, Halim, L, Draper, B, Parente-Pereira, A C, Zabinski, T, Davies, D M & Maher, J 2019, ' CAR T-cells targeting the integrin αvβ6 and co-expressing the chemokine receptor CXCR2 demonstrate enhanced homing and efficacy against several solid malignancies ', Cancers, vol. 11, no. 5, 674, pp. 1-17 . https://doi.org/10.3390/cancers11050674
Cancers, Vol 11, Iss 5, p 674 (2019)
Despite the unprecedented clinical success of chimeric antigen receptors (CAR) T-cells against haematological malignancy, solid tumors impose a far greater challenge to success. Largely, this stems from an inadequate capacity of CAR T-cells that can