Supplementary material from A Th1/IFNγ Gene Signature Is Prognostic in the Adjuvant Setting of Resectable High-Risk Melanoma but Not in Non–Small Cell Lung Cancer

Autor: Fernando Ulloa-Montoya, Jamila Louahed, Vincent G. Brichard, Bart Spiessens, Channa Debruyne, Patrick Therasse, Fawn Wang, Susana Salceda, Hans van Houwelingen, Jelle Goeman, Djordje Atanackovic, Lecia V. Sequist, Johan F. Vansteenkiste, John M. Kirkwood, Helen J. Gogas, Peter Hersey, Brigitte Dreno, Muriel Debois, Andrea Callegaro, Benjamin Dizier

Supplementary material

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5528f31009db1e47f0a2c403009ea8f6
https://doi.org/10.1158/1078-0432.22473330.v1

MAGE-A3 immunotherapeutic as adjuvant therapy for patients with resected, MAGE-A3-positive, stage III melanoma (DERMA): a double-blind, randomised, placebo-controlled, phase 3 trial

Autor: Benjamin Dizier, Andrea Callegaro, Robert M. Conry, Jean-Jacques Grob, Vincent Brichard, Laurent Machet, John F. Thompson, Evgeny Levchenko, Kamil Drucis, Mario Santinami, Gabriela Cinat, Sergii Korovin, John M. Kirkwood, Jaroslaw Jaroszek, Wim H. J. Kruit, Brigitte Dréno, Hans C. van Houwelingen, Bernard Guillot, Axel Hauschild, Jelle J. Goeman, Thomas Jouary, Peter Hersey, Ralf Gutzmer, Susana Puig, P. Therasse, Bernard Mark Smithers, Florent Grange, Bart Spiessens, Channa Debruyne, Piotr Rutkowski, Lev V. Demidov, Alessandro Testori, Igor Bondarenko, Muriel Debois, Fernando Ulloa-Montoya, Jamila Louahed, Ivana Krajsová, John A. Thompson

Publikováno v: The Lancet Oncology
The Lancet Oncology, 19(7), 916-929
Lancet Oncology
Lancet Oncology, Elsevier, 2018, 19 (7), pp.916--929. ⟨10.1016/S1470-2045(18)30254-7⟩
Lancet Oncology, 19(7), 916-929. Lancet Publishing Group

International audience; BACKGROUND: Despite newly approved treatments, metastatic melanoma remains a life-threatening condition. We aimed to evaluate the efficacy of the MAGE-A3 immunotherapeutic in patients with stage IIIB or IIIC melanoma in the ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3122602f081ca83557b035172ba56d69
https://doi.org/10.1016/s1470-2045(18)30254-7

Testing interaction between treatment and high-dimensional covariates in randomized clinical trials

Autor: Andrea, Callegaro, Bart, Spiessens, Benjamin, Dizier, Fernando U, Montoya, Hans C, van Houwelingen

Publikováno v: Biometrical journal. Biometrische Zeitschrift. 59(4)

In this paper, we considered different methods to test the interaction between treatment and a potentially large number (p) of covariates in randomized clinical trials. The simplest approach was to fit univariate (marginal) models and to combine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34132eb3513c6f3896fb365b341f5f45
https://pubmed.ncbi.nlm.nih.gov/27763683

Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy

Autor: Bart Spiessens, Frederic Lehmann, Wim H. J. Kruit, Fernando Ulloa-Montoya, Olivier Gruselle, Stefan Suciu, Vincent Brichard, Johan Vansteenkiste, Alexander M.M. Eggermont, Benjamin Dizier, Jamila Louahed

Publikováno v: Journal of Clinical Oncology, 31(19), 2388-2395. American Society of Clinical Oncology

Purpose To detect a pretreatment gene expression signature (GS) predictive of response to MAGE-A3 immunotherapeutic in patients with metastatic melanoma and to investigate its applicability in a different cancer setting (adjuvant therapy of resected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0664c9b3d41ee54f92c03769a40ca29
https://pure.eur.nl/en/publications/291385ec-309f-4c75-a9ab-cd0dc532e2b3