Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Benjamin D Gastfriend"'
Autor:
Benjamin D Gastfriend, Hideaki Nishihara, Scott G Canfield, Koji L Foreman, Britta Engelhardt, Sean P Palecek, Eric V Shusta
Publikováno v:
eLife, Vol 10 (2021)
Endothelial cells (ECs) in the central nervous system (CNS) acquire their specialized blood–brain barrier (BBB) properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of this process. Our knowledge
Externí odkaz:
https://doaj.org/article/f70aea41ef2d47e198496e27fd956b26
Autor:
Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek, Eric V. Shusta
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-12 (2019)
Abstract Background Brain microvascular endothelial cells (BMECs) astrocytes, neurons, and pericytes form the neurovascular unit (NVU). Interactions with NVU cells endow BMECs with extremely tight barriers via the expression of tight junction protein
Externí odkaz:
https://doaj.org/article/cf68e44965c54e5da97d6ddc617aba95
Autor:
Brandon J. Kim, Maura A. McDonagh, Liwen Deng, Benjamin D. Gastfriend, Alexandra Schubert-Unkmeir, Kelly S. Doran, Eric V. Shusta
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Bacterial meningitis is a serious life threatening infection of the CNS. To cause meningitis, blood–borne bacteria need to interact with and penetrate brain endothelial cells (BECs) that comprise the blood–brain barrier. BECs help mainta
Externí odkaz:
https://doaj.org/article/5b026e2c81f645b2a6038faaa1e46041
Autor:
Hideaki Nishihara, Benjamin D. Gastfriend, Pelin Kasap, Sean P. Palecek, Eric V. Shusta, Britta Engelhardt
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100563- (2021)
Summary: We describe the extended endothelial cell culture method (EECM) for the differentiation of human pluripotent stem cells (hPSCs) into brain microvascular endothelial cell (BMEC)-like cells. EECM-BMEC-like cells resemble primary human BMECs in
Externí odkaz:
https://doaj.org/article/405964aa45394bca9fb3c0faf138e3e3
Autor:
Lu Wang, Aaron F. Carlin, Benjamin D. Gastfriend, Joseph G. Gleeson, Alex E. Clark, David Sievert, Sean P. Palecek, Hannah Federman, Sangmoon Lee, Eric V. Shusta
Publikováno v:
Nature Medicine. 27:1600-1606
Clinical evidence suggests the central nervous system is frequently impacted by SARS-CoV-2 infection, either directly or indirectly, although the mechanisms are unclear. Pericytes are perivascular cells within the brain that are proposed as SARS-CoV-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccbb510119bf0f5acc1a692995a4b5e2
https://doi.org/10.1038/s41591-021-01443-1
https://doi.org/10.1038/s41591-021-01443-1
Autor:
Scott G. Canfield, Matthew J. Stebbins, Madeline G. Faubion, Benjamin D. Gastfriend, Sean P. Palecek, Eric V. Shusta
Publikováno v:
Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-1 (2019)
Following publication of the original article [1], the author has reported that in Figure 1 (b and c) the y-axis TEER (© x cm2) should be replaced with TEER (Ω x cm2).
Externí odkaz:
https://doaj.org/article/3b90274842684c01897927a970e60e5b
Autor:
Hideaki Nishihara, Eric V. Shusta, Sasha Soldati, Britta Engelhardt, Fabien Gosselet, Sylvain Perriot, Amandine Mathias, Takashi Kanda, Renaud Du Pasquier, Fumitaka Shimizu, Benjamin D. Gastfriend, Yasuteru Sano, Sean P. Palecek
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (12), pp.16693-16715. ⟨10.1096/fj.202001507RR⟩
Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR
FASEB journal, vol. 34, no. 12, pp. 16693-16715
The FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (12), pp.16693-16715. ⟨10.1096/fj.202001507RR⟩
Nishihara, Hideaki; Gastfriend, Benjamin D; Soldati, Sasha; Perriot, Sylvain; Mathias, Amandine; Sano, Yasuteru; Shimizu, Fumitaka; Gosselet, Fabien; Kanda, Takashi; Palecek, Sean P; Du Pasquier, Renaud; Shusta, Eric V; Engelhardt, Britta (2020). Advancing human induced pluripotent stem cell-derived blood-brain barrier models for studying immune cell interactions. FASEB journal, 34(12), pp. 16693-16715. Federation of American Societies for Experimental Biology 10.1096/fj.202001507RR
FASEB journal, vol. 34, no. 12, pp. 16693-16715
The FASEB Journal
International audience; Human induced pluripotent stem cell (hiPSC)-derived blood-brain barrier (BBB) models established to date lack expression of key adhesion molecules involved in immune cell migration across the BBB in vivo. Here, we introduce th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9dcb79461a39689b0dd309b32ace46
https://doi.org/10.1096/fj.202001507rr
https://doi.org/10.1096/fj.202001507rr
Autor:
Benjamin D. Gastfriend, Kelsey Tweed, Daniel A. Gil, Emmanuel Contreras Guzman, Melissa C. Skala, Sean P. Palecek, Tongcheng Qian
Publikováno v:
Lab Chip
Endothelial cells (EC) in vivo are continuously exposed to a mechanical microenvironment from blood flow, and fluidic shear stress plays an important role in EC behavior. New approaches to generate physiologically and pathologically relevant pulsatil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bdf380ac1b06cb67690e52105f2a0a
https://doi.org/10.1039/d0lc00546k
https://doi.org/10.1039/d0lc00546k
Publikováno v:
Pharm Res
The blood-brain barrier (BBB) hinders therapeutic delivery to the central nervous system (CNS), thereby impeding the development of therapies for brain injury and disease. Receptor-mediated transcytosis (RMT) systems are a promising way to shuttle a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc4db9ed6331107f505e22bce178340
https://europepmc.org/articles/PMC9250590/
https://europepmc.org/articles/PMC9250590/
Autor:
Hideaki Nishihara, Sylvain Perriot, Benjamin D Gastfriend, Marel Steinfort, Celine Cibien, Sasha Soldati, Kinya Matsuo, Sarah Guimbal, Amandine Mathias, Sean P Palecek, Eric V Shusta, Renaud Du Pasquier, Britta Engelhardt
Publikováno v:
Brain
Nishihara, Hideaki; Perriot, Sylvain; Gastfriend, Benjamin D; Steinfort, Marel; Cibien, Celine; Soldati, Sasha; Matsuo, Kinya; Guimbal, Sarah; Mathias, Amandine; Palecek, Sean P; Shusta, Eric V; Du Pasquier, Renaud; Engelhardt, Britta (2022). Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a journal of neurology, 145(12), pp. 4334-4348. Oxford University Press 10.1093/brain/awac019
Nishihara, Hideaki; Perriot, Sylvain; Gastfriend, Benjamin D; Steinfort, Marel; Cibien, Celine; Soldati, Sasha; Matsuo, Kinya; Guimbal, Sarah; Mathias, Amandine; Palecek, Sean P; Shusta, Eric V; Du Pasquier, Renaud; Engelhardt, Britta (2022). Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis. Brain : a journal of neurology, 145(12), pp. 4334-4348. Oxford University Press 10.1093/brain/awac019
Blood–brain barrier (BBB) breakdown and immune cell infiltration into the CNS are early hallmarks of multiple sclerosis (MS). The mechanisms leading to BBB dysfunction are incompletely understood and generally thought to be a consequence of neuroin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065a915df760d8316fecaad7d4aff502
https://europepmc.org/articles/PMC10200307/
https://europepmc.org/articles/PMC10200307/