Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Benjamin D, Sellers"'
Autor:
Dawei Sun, Kelly M. Storek, Dimitry Tegunov, Ying Yang, Christopher P. Arthur, Matthew Johnson, John G. Quinn, Weijing Liu, Guanghui Han, Hany S. Girgis, Mary Kate Alexander, Austin K. Murchison, Stephanie Shriver, Christine Tam, Hiroshi Ijiri, Hiroko Inaba, Tatsuya Sano, Hayato Yanagida, Junichi Nishikawa, Christopher E. Heise, Wayne J. Fairbrother, Man-Wah Tan, Nicholas Skelton, Wendy Sandoval, Benjamin D. Sellers, Claudio Ciferri, Peter A. Smith, Patrick C. Reid, Christian N. Cunningham, Steven T. Rutherford, Jian Payandeh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract BamA is the central component of the essential β-barrel assembly machine (BAM), a conserved multi-subunit complex that dynamically inserts and folds β-barrel proteins into the outer membrane of Gram-negative bacteria. Despite recent advanc
Externí odkaz:
https://doaj.org/article/bf48c6d78a39468c81c644c4c61faa56
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 50 (2023)
Drug nanosuspensions offer a promising approach to improve bioavailability for poorly soluble drug candidates. Such formulations often necessitate the inclusion of an excipient to stabilize the drug nanoparticles. However, the rationale for the choic
Externí odkaz:
https://doaj.org/article/4973d715132a4c57a08a10df73a9ad9d
Autor:
Jesse E. Hanson, Keran Ma, Justin Elstrott, Martin Weber, Sandrine Saillet, Abdullah S. Khan, Jeffrey Simms, Benjamin Liu, Thomas A. Kim, Gui-Qiu Yu, Yelin Chen, Tzu-Ming Wang, Zhiyu Jiang, Bianca M. Liederer, Gauri Deshmukh, Hilda Solanoy, Connie Chan, Benjamin D. Sellers, Matthew Volgraf, Jacob B. Schwarz, David H. Hackos, Robby M. Weimer, Morgan Sheng, T. Michael Gill, Kimberly Scearce-Levie, Jorge J. Palop
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Summary: NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR
Externí odkaz:
https://doaj.org/article/086ee7e911424901b05bcdfb74e615c9
Autor:
Man-Ling Lee, Ignacio Aliagas, Jianwen A. Feng, Thomas Gabriel, T. J. O’Donnell, Benjamin D. Sellers, Bernd Wiswedel, Alberto Gobbi
Publikováno v:
Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-14 (2017)
Abstract Background Analyzing files containing chemical information is at the core of cheminformatics. Each analysis may require a unique workflow. This paper describes the chemalot and chemalot_knime open source packages. Chemalot is a set of comman
Externí odkaz:
https://doaj.org/article/edfb9c52e3044076802ecdada87add4f
Publikováno v:
Journal of Computer-Aided Molecular Design. 36:253-262
In drug discovery, partition and distribution coefficients, logP and logD for octanol/water, are widely used as metrics of the lipophilicity of molecules, which in turn have a strong influence on the bioactivity and bioavailability of potential drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf800594ce6384f55f2d77d79a45929
https://doi.org/10.1007/s10822-022-00450-9
https://doi.org/10.1007/s10822-022-00450-9
Autor:
Anh Miu, Benjamin D. Sellers, Maria Ruiz-Gonzalez, Jian Payandeh, Peter Liu, L. Martin, Kerry R Buchholz, Dewakar Sangaraju, Guanghui Han, Mark S. Hunter, Elizabeth Skippington, Wendy Sandoval, Emily J. Hanan, Cameron L. Noland, Trisha Dela Vega, Daniel P. DePonte, Erik Verschueren, Danielle L. Swem, Min Xu, Sheerin K. Shahidi-Latham, Nicholas N. Nickerson, Summer Park, Steven T. Rutherford, Nicholas J. Skelton, Qingling Li, Janina Reeder, Kelly M. Storek, Cornelius Gati, Thomas Clairfeuille
Publikováno v:
Nature. 584:479-483
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it is responsible for barrier function1,2. LPS can cause death as a result of septic shock, and its lipid A core is the target of polymyxin antibiotics3,4. Despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d60f6821b117c57797c53d6a1fae98ab
https://doi.org/10.1038/s41586-020-2597-x
https://doi.org/10.1038/s41586-020-2597-x
Autor:
Wen Liu, Amy Gustafson, Firoz Jaipuri, Erica VanderPorten, Leanne Goon, Yamin Zhang, Guosheng Wu, Zuhui Zhang, Antonio G. DiPasquale, Xiaokai Li, Angela J. Oh, Lewis J. Gazzard, Seth F. Harris, Jesse Waldo, Roheeth Kumar Pavana, Yichin Liu, Venkata Velvadapu, Cheng Shao, Yuen Po-Wai, Mario R. Mautino, Zhonghua Pei, Hank La, Hima Potturi, Georgette Castanedo, Benjamin D. Sellers, Kevin DeMent, Sanjeev Kumar, Richard Pastor, Rohan Mendonca, Brendan T. Parr
Publikováno v:
ACS Med Chem Lett
[Image: see text] A class of imidazoisoindole (III) heme-binding indoleamine-2,3-dioxygenase (IDO1) inhibitors were optimized via structure-based drug design into a series of tryptophan-2,3-dioxygenase (TDO)-selective inhibitors. Kynurenine pathway m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd22f186bad66eefde1770830d8d6
https://doi.org/10.1021/acsmedchemlett.0c00004
https://doi.org/10.1021/acsmedchemlett.0c00004
Autor:
Hilda Solanoy, Morgan Sheng, Gui-Qiu Yu, Jesse E. Hanson, Gauri Deshmukh, Benjamin D. Sellers, Tzu-Ming Wang, Yelin Chen, Justin Elstrott, Connie Chan, Zhiyu Jiang, Thomas A. Kim, David H. Hackos, Jacob Schwarz, Jorge J. Palop, T. Michael Gill, Matthew Volgraf, Keran Ma, Jeffrey Simms, Kimberly Scearce-Levie, Martin Weber, Bianca M. Liederer, Sandrine Saillet, Abdullah S. Khan, Robby M. Weimer, Benjamin Liu
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 381-396.e4 (2020)
Elsevier
Cell reports, vol 30, iss 2
Cell reports
Elsevier
Cell reports, vol 30, iss 2
Cell reports
SUMMARY NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0ddfb3fdc3d2e4aa7d6b4342a59d2
http://www.sciencedirect.com/science/article/pii/S2211124719316808
http://www.sciencedirect.com/science/article/pii/S2211124719316808
Autor:
Shuzhe Wang, Kajo Krummenacher, Gregory A. Landrum, Benjamin D. Sellers, Paola Di Lello, Sarah J. Robinson, Bryan Martin, Jeffrey K. Holden, Jeffrey Y. K. Tom, Anastasia C. Murthy, Nataliya Popovych, Sereina Riniker
Publikováno v:
Journal of Chemical Information and Modeling, 62 (3)
Nuclear magnetic resonance (NMR) data from NOESY (nuclear Overhauser enhancement spectroscopy) and ROESY (rotating frame Overhauser enhancement spectroscopy) experiments can easily be combined with distance geometry (DG) based conformer generators by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be588fd903726483da66251ef95913c1
Autor:
Qi Jia, Jean-Christophe Andrez, Charles J. Cohen, Jae H. Chang, Kuldip Khakh, J. P. Johnson, Chien-An Chen, Jun Li, Karen Nelkenbrecher, Thilo Focken, Zhiwei Xie, Daniel F. Ortwine, Brian Safina, Michael Edward Grimwood, Andrew D. White, Christoph Martin Dehnhardt, Shannon Decker, Ivan William Hemeon, David H. Hackos, Sophia Lin, Jodie Pang, Luis Sojo, Girish Bankar, Andrea Lindgren, Matthew Waldbrook, Elaine Chang, C. Lee Robinette, Shaoyi Sun, Antonio G. DiPasquale, Tao Sheng, Clint Young, Rainbow Kwan, Benjamin D. Sellers, Sultan Chowdhury, Michael Scott Wilson, Lunbin Deng, Daniel P. Sutherlin, Alla Yurevna Zenova
Publikováno v:
Journal of Medicinal Chemistry. 62:908-927
Herein, we report the discovery and optimization of a series of orally bioavailable acyl sulfonamide NaV1.7 inhibitors that are selective for NaV1.7 over NaV1.5 and highly efficacious in in vivo models of pain and hNaV1.7 target engagement. An analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f65c95248ff36af0807edf4a8f95cad
https://doi.org/10.1021/acs.jmedchem.8b01621
https://doi.org/10.1021/acs.jmedchem.8b01621