Výsledky vyhledávání - "Benjamin D, Sachs"

Akademický článek

The effects of amphetamine exposure on stress susceptibility in mice

Publikováno v: Addiction Neuroscience, Vol 13, Iss , Pp 100176- (2024)

Substance use disorders (SUDs) and their many psychiatric comorbidities, including major depression and anxiety disorders, are characterized by significant sex differences. Although the causes of SUDs and their psychiatric comorbidities remain unknow

Externí odkaz: https://doaj.org/article/19713fb559204449be08ca7adcc2109d

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Akademický článek

Genetic loss of the dopamine transporter significantly impacts behavioral and molecular responses to sub-chronic stress in mice

Autor: Avelina Petri, Abigail Sullivan, Kristen Allen, Benjamin D. Sachs

Publikováno v: Frontiers in Molecular Neuroscience, Vol 17 (2024)

Dopaminergic neurotransmission has emerged as a critical determinant of stress susceptibility and resilience. Although the dopamine transporter (DAT) is known to play a key role in maintaining dopamine (DA) homeostasis, its importance for the regulat

Externí odkaz: https://doaj.org/article/3ec85da204f9400dafcee4ac6b2dd6b0

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Akademický článek

Chronic, but not sub-chronic, stress increases binge-like alcohol consumption in male and female c57BL6 mice

Autor: William McCarthy, Shama N. Huq, Kristen Allen, Lindsay Scally, Avelina Petri, Madeline Wujek, Benjamin D. Sachs

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 16 (2022)

Stress is known to contribute to mental illness and alcohol use disorders, which are highly prevalent and lead to considerable disability. These stress-related disorders are characterized by significant sex differences, which remain poorly understood

Externí odkaz: https://doaj.org/article/3340148c994f4caab60cb61778de3518

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Akademický článek

Early life maternal separation induces sex-specific antidepressant-like responses but has minimal effects on adult stress susceptibility in mice

Autor: Brittany J. Baugher, Benjamin D. Sachs

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 16 (2022)

Early life stress is known to increase the risk of depression and anxiety disorders, which are highly prevalent conditions that disproportionately affect women. However, the results of preclinical studies have been mixed, with some work suggesting th

Externí odkaz: https://doaj.org/article/b796749a964f4cc98bfec31c93ad8632

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Akademický článek

The Effects of Brain Serotonin Deficiency on Responses to High Fat Diet in Female Mice

Autor: Shama N. Huq, Allison K. Warner, Kerry Buckhaults, Benjamin D. Sachs

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

Clinical studies have reported an increased risk of depression and anxiety disorders among individuals who are obese, and women are more likely than men to suffer from depression, anxiety, and obesity. However, the effects of obesity-promoting diets

Externí odkaz: https://doaj.org/article/0cfeb2a96bfe40e5830dd952a9b88532

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Akademický článek

Brain 5-HT Deficiency Prevents Antidepressant-Like Effects of High-Fat-Diet and Blocks High-Fat-Diet-Induced GSK3β Phosphorylation in the Hippocampus

Autor: Michelle M. Karth, Brittany J. Baugher, Nicole Daly, Melinda D. Karth, Stephen C. Gironda, Benjamin D. Sachs

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)

Obesity is associated with an increased risk of depression and anxiety disorders, but the nature of the relationship(s) between obesity and mental illness remains highly controversial. Some argue that depression and anxiety lead to increased consumpt

Externí odkaz: https://doaj.org/article/c320565bd4f64d909a0545a28735d1c1

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Akademický článek

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

Autor: Bernat Baeza-Raja, Benjamin D. Sachs, Pingping Li, Frank Christian, Eirini Vagena, Dimitrios Davalos, Natacha Le Moan, Jae Kyu Ryu, Shoana L. Sikorski, Justin P. Chan, Miriam Scadeng, Susan S. Taylor, Miles D. Houslay, George S. Baillie, Alan R. Saltiel, Jerrold M. Olefsky, Katerina Akassoglou

Publikováno v: Cell Reports, Vol 14, Iss 2, Pp 255-268 (2016)

Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD). Despite no c

Externí odkaz: https://doaj.org/article/6df01ed55e9b4e4795aea5d1c5382970

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