Výsledky vyhledávání - "Benjamin D, Hedley"

Akademický článek

Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review

Autor: Shamim Mortuza, Benjamin Chin-Yee, Tyler E. James, Ian H. Chin-Yee, Benjamin D. Hedley, Jenny M. Ho, Lalit Saini, Alejandro Lazo-Langner, Laila Schenkel, Pratibha Bhai, Bekim Sadikovic, Jonathan Keow, Nikhil Sangle, Cyrus C. Hsia

Publikováno v: Current Oncology, Vol 31, Iss 4, Pp 1762-1773 (2024)

Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5–14% RS and an SF3B1 mutation. In the MEDALIST trial and in an interim analysis of the COMMANDS tr

Externí odkaz: https://doaj.org/article/1389c9740fa14069b7cf278763e6f132

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Akademický článek

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern

Publikováno v: JCI Insight, Vol 6, Iss 13 (2021)

BACKGROUND The role of humoral immunity in COVID-19 is not fully understood, owing, in large part, to the complexity of antibodies produced in response to the SARS-CoV-2 infection. There is a pressing need for serology tests to assess patient-specifi

Externí odkaz: https://doaj.org/article/0e57c4e14f114734909f6cbfa9ee20fd

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Akademický článek

Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies

Autor: Sally Esmail, Michael J. Knauer, Husam Abdoh, Courtney Voss, Benjamin Chin-Yee, Peter Stogios, Almagul Seitova, Ashley Hutchinson, Farhad Yusifov, Tatiana Skarina, Elena Evdokimova, Suzanne Ackloo, Lori Lowes, Benjamin D. Hedley, Vipin Bhayana, Ian Chin-Yee, Shawn S.-C. Li

Publikováno v: Cell Reports: Methods, Vol 1, Iss 2, Pp 100011- (2021)

Summary: We have developed a rapid, accurate, and cost-effective serologic test for SARS-CoV-2 virus, which caused the COVID-19 pandemic, on the basis of antibody-dependent agglutination of antigen-coated latex particles. When validated using plasma

Externí odkaz: https://doaj.org/article/3f2477e5691a4aa0ad3217aa0d9e0c9c

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T‐cell clonality testing for the diagnosis of T‐cell large granular lymphocytic leukemia: Are we identifying pathology or incidental clones?

Autor: Benjamin Chin‐Yee, Abitha Suthakaran, Benjamin D. Hedley, Christopher Howlett, Alan Stuart, Bekim Sadikovic, Ian H. Chin‐Yee, Cyrus C. Hsia

Publikováno v: International Journal of Laboratory Hematology. 44:1115-1120

T-cell clonality testing by T-cell receptor (TCR) gene rearrangement is key to the diagnosis of T-cell lymphoproliferative disorders such as T-cell large granular lymphocytic (T-LGL) leukemia. Benign clonal T-cell expansions, however, are commonly fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0210c24abcd384c9f5002e94784fb3e7
https://doi.org/10.1111/ijlh.13949

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Supplementary Figure 2 from Recombinant Human Erythropoietin in Combination with Chemotherapy Increases Breast Cancer Metastasis in Preclinical Mouse Models

Autor: Anargyros Xenocostas, Alison L. Allan, Alexandra Boasie, Michel S. Beausoleil, D. George Ormond, Jenny E. Chu, Benjamin D. Hedley

PDF file - 1147KB, 2 x 106 MDA-MB-231 or MDA-MB-435 cells were injected into 6- to 7-week-old female NOD/SCID or nu/nu mice via mammary fat pad. The control cohort (n=4) received weekly saline subcutaneous injections, while three other cohorts (n=4 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5495c2af1e141a8b23efdaf8637e7b70
https://doi.org/10.1158/1078-0432.22445049

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Supplementary Tables 1-4 from Recombinant Human Erythropoietin in Combination with Chemotherapy Increases Breast Cancer Metastasis in Preclinical Mouse Models

Autor: Anargyros Xenocostas, Alison L. Allan, Alexandra Boasie, Michel S. Beausoleil, D. George Ormond, Jenny E. Chu, Benjamin D. Hedley

PDF file - 119KB, Supplemental Table 1- Cell lines used. Supplemental Table 2 - PCR primers and cycling conditions. Supplemental Table 3 - Anti Human EPOR antibodies used. Supplemental Table 4 - In Vivo hemoglobin measurements.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc66cbb3fa95c4095969085c99c81cf0
https://doi.org/10.1158/1078-0432.22445046

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Data from Recombinant Human Erythropoietin in Combination with Chemotherapy Increases Breast Cancer Metastasis in Preclinical Mouse Models

Autor: Anargyros Xenocostas, Alison L. Allan, Alexandra Boasie, Michel S. Beausoleil, D. George Ormond, Jenny E. Chu, Benjamin D. Hedley

Purpose: Erythropoiesis-stimulating agents (ESA) are used clinically for treating cancer-related anemia. Recent clinical trials have reported increased adverse events and reduced survival in ESA-treated breast cancer patients receiving chemotherapy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::566eee8085d166db9fb30b5a7e9f059c
https://doi.org/10.1158/1078-0432.c.6520371

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Supplementary Figure 1 from Recombinant Human Erythropoietin in Combination with Chemotherapy Increases Breast Cancer Metastasis in Preclinical Mouse Models

Autor: Anargyros Xenocostas, Alison L. Allan, Alexandra Boasie, Michel S. Beausoleil, D. George Ormond, Jenny E. Chu, Benjamin D. Hedley

PDF file - 145KB, EPOR and JAK2 amplification was normalized to GAPDH intensity for mBM, UT7/EPO, 3T3, H838, MDA-MB-435, MDA-MB-231, MDA-MB-468 and 4T1 samples, with (*) or without rHuEPO treatment and subjected to densitometric analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3096a222d2cc9c6060829a0cebdead76
https://doi.org/10.1158/1078-0432.22445052

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Measurable Residual Disease Detection in B-Acute Lymphoblastic Leukemia: The Children's Oncology Group (COG) Method

Autor: Michael J. Borowitz, Brent L. Wood, Michael Keeney, Benjamin D. Hedley

Publikováno v: Current protocolsLiterature Cited. 2(3)

Measurable (minimal) residual disease (MRD) in B-acute lymphoblastic leukemia (B-ALL), as assessed by flow cytometry, is an established prognostic factor used to adjust treatment in most pediatric therapeutic protocols. MRD in B-ALL has been standard

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de206de2f41ced05ecb02fac3bafa37
https://pubmed.ncbi.nlm.nih.gov/35263042

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Clinical Utility of Implementing a Frontline NGS-Based DNA and RNA Fusion Panel Test for Patients with Suspected Myeloid Malignancies

Autor: Pratibha Bhai, Cyrus C. Hsia, Laila C. Schenkel, Benjamin D. Hedley, Michael A. Levy, Jennifer Kerkhof, Stephanie Santos, Alan Stuart, Hanxin Lin, Robert Broadbent, Shirley Nan, Ping Yang, Anargyros Xenocostas, Ian Chin-Yee, Bekim Sadikovic

Publikováno v: Molecular diagnosistherapy. 26(3)

The use of molecular genetic biomarkers is rapidly advancing to aid diagnosis, prognosis, and clinical management of hematological disorders. We have implemented a next-generation sequencing (NGS) assay for detection of genetic variants and fusions a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dec45d83476a0c2ce1cb70b4e393f3
https://pubmed.ncbi.nlm.nih.gov/35381971

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