Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Benjamin C. Whitehurst"'
Autor:
Simon C.C. Lucas, J. Henry Blackwell, Sarah H. Hewitt, Hannah Semple, Benjamin C. Whitehurst, Hua Xu
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100142- (2024)
Covalent hits for drug discovery campaigns are neither fantastic beasts nor mythical creatures, they can be routinely identified through electrophile-first screening campaigns using a suite of different techniques. These include biophysical and bioch
Externí odkaz:
https://doaj.org/article/27d924496e8440509ecb62d8a6268f4d
Autor:
Benjamin C. Whitehurst, Matthias R. Bauer, Fredrik Edfeldt, Anders Gunnarsson, Christian Margreitter, Philip B. Rawlins, R. Ian Storer
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ac4872dc5340487462910b8549354e
https://doi.org/10.1021/acs.jmedchem.3c00493
https://doi.org/10.1021/acs.jmedchem.3c00493
Autor:
Jennifer E. Nelson, Simon C. C. Lucas, Iacovos N Michaelides, Matthias R. Bauer, Benjamin C Whitehurst, R. Ian Storer, Paolo Di Fruscia
Publikováno v:
RSC Med Chem
Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly exploited in medicinal chemistry for their beneficial physicochemical properties and applications a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f297b29e4248cacc143b0578d2195082
https://doi.org/10.1039/d0md00370k
https://doi.org/10.1039/d0md00370k
Autor:
Robert J. Young, Pedro Torres, Monica Cacho, Benjamin C. Whitehurst, Laura Vela-Gonzalez del Peral, Glenn A. Burley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127192
The identification of a novel series of DprE1 inhibitors based on a 2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-N-phenylpropanamide scaffold is described herein. SAR exploration around the HTS hit 1 led to the identification of multiple analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cda1c76f6c899d2ca1a8a3aeedf6ec0
https://doi.org/10.1016/j.bmcl.2020.127192
https://doi.org/10.1016/j.bmcl.2020.127192
Autor:
Marine Z. C. Hatit, Allan J. B. Watson, Ciaran P. Seath, Joanna C. Sadler, Benjamin C. Whitehurst, Luke D. Humphreys, Glenn A. Burley, Liam A. McLean, Robert J. Young
Publikováno v:
ChemInform. 47
Aromatic ynamines or N-alkynylheteroarenes are highly reactive alkyne components in Cu-catalyzed Huisgen [3 + 2] cycloaddition ("click") reactions. This enhanced reactivity enables the chemoselective formation of 1,4-triazoles using the representativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::437b6c1046c43d13fd5d0219830ee8a1
https://doi.org/10.1002/chin.201632142
https://doi.org/10.1002/chin.201632142
Autor:
Glenn A. Burley, Joanna C. Sadler, Ciaran P. Seath, Allan J. B. Watson, Liam A. McLean, Robert J. Young, Marine Z. C. Hatit, Benjamin C. Whitehurst, Luke D. Humphreys
Publikováno v:
Organic Letters. 18:2326-2326
Aromatic ynamines or N-alkynylheteroarenes are highly reactive alkyne components in Cu-catalyzed Huisgen [3 + 2] cycloaddition ("click") reactions. This enhanced reactivity enables the chemoselective formation of 1,4-triazoles using the representativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cd4a5f514005bc3200bb31ae327e7f
https://doi.org/10.1021/acs.orglett.6b01021
https://doi.org/10.1021/acs.orglett.6b01021