Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Benjamin C. Onyeagucha"'
Autor:
Nourhan Abdelfattah, Subapriya Rajamanickam, Subbarayalu Panneerdoss, Santosh Timilsina, Pooja Yadav, Benjamin C. Onyeagucha, Michael Garcia, Ratna Vadlamudi, Yidong Chen, Andrew Brenner, Peter Houghton, Manjeet K. Rao
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The radiation and chemotherapy used for treating medulloblastoma patients cause debilitating side effects. Here, the authors show that miR-584 acts as a therapeutic adjuvant as it sensitizes medulloblastoma to radiation and chemotherapy by targeting
Externí odkaz:
https://doaj.org/article/7e6b817f247d44dd9e1ce5001fd43f4d
Autor:
Subbarayalu Panneerdoss, Suryavathi Viswanadhapalli, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Santosh Timilsina, Tabrez A. Mohammad, Yidong Chen, Michael Drake, Kristiina Vuori, T. Rajendra Kumar, Manjeet K. Rao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Although phagocytic clearance of apoptotic germ cells by Sertoli cells is essential for spermatogenesis, little of the mechanism is known. Here the authors show that Sertoli cells employ LC3-associated phagocytosis (LAP) by recruiting autophagy membe
Externí odkaz:
https://doaj.org/article/14e208c481df43b3b2eb76f2b8f0b5a9
Autor:
Tabrez A. Mohammad, Subapriya Rajamanickam, Manjeet K. Rao, Benjamin C. Onyeagucha, Sanjay Bansal, Panneerdoss Subbarayalu, Carla Zeballos, Yi Chen, Nourhan Abdelfattah, Vijay Kumar Eedunuri, Ratna K. Vadlamudi, Rosa M. Guzman, Santosh Timilsina
Publikováno v:
Oncotarget
Deregulation of apoptosis is central to cancer progression and a major obstacle to effective treatment. The Bcl-2 gene family members play important roles in the regulation of apoptosis and are frequently altered in cancers. One such member is pro-ap
Autor:
Tabrez A. Mohammad, Suryavathi Viswanadhapalli, Subbarayalu Panneerdoss, Nourhan Abdelfattah, Benjamin C. Onyeagucha, Yi Chen, Michael T. Drake, T. Rajendra Kumar, Kristiina Vuori, Manjeet K. Rao, Santosh Timilsina
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications
Nature Communications
Phagocytic clearance of apoptotic germ cells by Sertoli cells is vital for germ cell development and differentiation. Here, using a tissue-specific miRNA transgenic mouse model, we show that interaction between miR-471-5p and autophagy member protein
Autor:
X Cui, Santosh Timilsina, Nourhan Abdelfattah, Yi Chen, Th-M Huang, Manjeet K. Rao, Benjamin C. Onyeagucha, Subapriya Rajamanickam, Yi-Wen Huang, Tabrez A. Mohammad, Vijay Kumar Eedunuri, Panneerdoss Subbarayalu, Suryavathi Viswanadhapalli
Publikováno v:
Cancer Research. 77:P1-04
The importance of RNA methylation in biological processes has just begun to emerge. However, our understanding of the role and mechanism by which RNA methylation may play a role in tumorigenesis is unclear. Here, we report that RNA N6-adenosine methy
Autor:
Pooja Yadav, Tabrez A. Mohammad, Saif Sr Nirzhor, Li-Ju Wang, Benjamin C Onyeagucha, Suryavathi Viswanadhapalli, Yi Chen, Panneerdoss Subbarayalu, Yu-Chiao Chiu, Subapriya Rajamanickam, Vijay Kumar Eedunuri, Nourhan Abdelfattah, Manjeet K. Rao, Nicholas F. Dybdal-Hargreaves, Esha Reddy, Ratna K. Vadlamudi, Fuyang Li, Santosh Timilsina
Publikováno v:
Cancer Research. 81:PS19-14
Despite improvement in overall survival, many patients with breast cancers still succumb to this disease. Identification of new biomarkers and safe therapeutic targets are urgently needed to improve the overall clinical outcome of breast cancer patie
Autor:
Alexander J.R. Bishop, Benjamin C. Onyeagucha, Santosh Timilsina, Yi Chen, Martha A. Hanes, Jack L. Arbiser, Dmytro Kovalskyy, Dmitri N. Ivanov, Subbarayalu Panneerdoss, Aparna Gorthi, Ratna K. Vadlamudi, Manjeet K. Rao, Subapriya Rajamanickam
Publikováno v:
Clinical Cancer Research. 22:3524-3536
Purpose: The approaches aimed at inhibiting the ability of cancer cells to repair DNA strand breaks have emerged as promising targets for treating cancers. Here, we assessed the potential of imipramine blue (IB), a novel analogue of antidepressant im
Autor:
Vijay K. Eedunuuri, Subbarayalu Panneerdoss, Manjeet K. Rao, Tabrez A. Mohammad, Subapriya Rajamanickam, Santosh Timilsina, Kashish Dhillon, Benjamin C. Onyeagucha, Yi Chen
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 29:B066-B066
The development of novel targeted therapies is urgently required for improving the outcome of breast cancer patients. Chemotherapy is the common treatment option for malignant breast cancer. However, resistance and toxicity remain the major obstacles
Autor:
Santosh Timilsina, Tabrez A. Mohammad, Zhao Lai, Nourhan Abdelfattah, Suryavathi Viswanadhapalli, Yi Chen, Benjamin C. Onyeagucha, Tim H M Huang, Xiadong Cui, Manjeet K. Rao, Subbarayalu Panneerdoss, Subapriya Rajamanickam, Vijay Kumar Eedunuri, Yogesh K. Gupta, Yufei Huang, Pooja Yadav
Publikováno v:
Science Advances. 4
The importance of RNA methylation in biological processes is an emerging focus of investigation. We report that altering m6A levels by silencing either N6-adenosine methyltransferase METTL14 (methyltransferase-like 14) or demethylase ALKBH5 (ALKB hom
Autor:
Subbarayalu, Panneerdoss, Vijay K, Eedunuri, Pooja, Yadav, Santosh, Timilsina, Subapriya, Rajamanickam, Suryavathi, Viswanadhapalli, Nourhan, Abdelfattah, Benjamin C, Onyeagucha, Xiadong, Cui, Zhao, Lai, Tabrez A, Mohammad, Yogesh K, Gupta, Tim Hui-Ming, Huang, Yufei, Huang, Yidong, Chen, Manjeet K, Rao
Publikováno v:
Science Advances
Collaboration among writers-readers-erasers of m6A regulates the stability of tumor-specific genes.
The importance of RNA methylation in biological processes is an emerging focus of investigation. We report that altering m6A levels by silencing
The importance of RNA methylation in biological processes is an emerging focus of investigation. We report that altering m6A levels by silencing