Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Benjamin C, Shaw"'
Autor:
Benjamin C. Shaw, Jessica L. Williams
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
IntroductionMultiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Current therapies primarily target the inflammatory component of the disease and are highly effective in early stages of MS while li
Externí odkaz:
https://doaj.org/article/714fbd7cf35e4ea09df82600be6f1df3
Autor:
Diana J. Zajac, Benjamin C. Shaw, David J. Braun, Stefan J. Green, Joshua M. Morganti, Steven Estus
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Elucidating the impact of the gut microbiome on Alzheimer’s Disease (AD) is an area of intense interest. Short chain fatty acids (SCFAs) are major microbiota metabolites that have been implicated as a mediator of gut microbiome effects in the brain
Externí odkaz:
https://doaj.org/article/0e0f9a3173cb4dbe9d911738d6da7bba
Publikováno v:
Immunological Reviews. 311:39-49
The blood-brain barrier (BBB) is a selectively permeable barrier separating the periphery from the central nervous system (CNS). The BBB restricts the flow of most material into and out of the CNS, including many drugs that could be used as potent th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5c580e931279bfef18d7d8974f1a06
https://doi.org/10.1111/imr.13121
https://doi.org/10.1111/imr.13121
Autor:
Benjamin C Shaw, Ann M. Stowe, Melissa Kesler, Jadwiga Turchan-Cholewo, Thomas A. Ujas, Chintan Rupareliya, G Benton Maglinger, Keith R. Pennypacker, Justin F. Fraser, Mathias Gelderblom, Stephen Grupke
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
Using standard techniques during mechanical thrombectomy, the Blood and Clot Thrombectomy Registry and Collaboration (BACTRAC) protocol (NCT03153683) isolates intracranial arterial blood distal to the thrombus and proximal systemic blood in the carot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffed3dd155544a85d824e4eddbaa60e8
https://doi.org/10.1177/0271678x211028496
https://doi.org/10.1177/0271678x211028496
Publikováno v:
Genes. 13(9)
Elucidating the actions of genetic polymorphisms associated with the risk of Alzheimer's disease (AD) may provide novel insights into underlying mechanisms. Two polymorphisms have implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::092c7813423b31c6c192e1693918a90a
https://pubmed.ncbi.nlm.nih.gov/36140776
https://pubmed.ncbi.nlm.nih.gov/36140776
An Alternatively Spliced TREM2 Isoform Lacking the Ligand Binding Domain is Expressed in Human Brain
Autor:
Benjamin C. Shaw, Henry C. Snider, Andrew K. Turner, Diana J. Zajac, James F. Simpson, Steven Estus
Publikováno v:
J Alzheimers Dis
Background: Genetic variants in TREM2 are strongly associated with Alzheimer’s disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described. Objective: Recognizing that alternative splice variants can resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854e8ad2d84eeafaf45364ffaf5dce05
https://pubmed.ncbi.nlm.nih.gov/35527547
https://pubmed.ncbi.nlm.nih.gov/35527547
An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain
BackgroundGenetic variants in TREM2 are strongly associated with Alzheimer’s Disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described.ObjectiveRecognizing that alternative splice variants can result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b44e7411a7607c9cb51a702bca1c13ac
https://doi.org/10.1101/2021.11.23.469712
https://doi.org/10.1101/2021.11.23.469712
Autor:
Benjamin C, Shaw, Steven, Estus
Publikováno v:
CRISPR J
Although gene editing workflows typically consider the possibility of off-target editing, pseudogene-directed homology repair has not, to our knowledge, been reported previously. Here, we employed a CRISPR-Cas9 strategy for targeted excision of exon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::492955607a55abebd21e65683d9e9333
https://pubmed.ncbi.nlm.nih.gov/34558988
https://pubmed.ncbi.nlm.nih.gov/34558988
Autor:
David W. Fardo, Gregory A. Jicha, Donna W Wilcock, Steven Estus, Angela Wei, Dana M. Niedowicz, Sonya Anderson, Douglas A. Price, Janna H. Neltner, Peter T. Nelson, Benjamin C. Shaw, Linda J. Van Eldik, Sergey Artiushin, Adam D. Bachstetter, Indumati Patel, Erin L. Abner, Bela G Nelson, Lena J Brzezinski, Wang-Xia Wang, Qingwei Huang, Yuriko Katsumata
Publikováno v:
Journal of Neuropathology and Experimental Neurology
We found evidence of late-onset Alzheimer disease (LOAD)-associated genetic polymorphism within an exon of Mucin 6 (MUC6) and immediately downstream from another gene: Adaptor Related Protein Complex 2 Subunit Alpha 2 (AP2A2). PCR analyses on genomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626d3cab8184f0ffcd034ebb748b49b8
https://doi.org/10.1093/jnen/nlz116
https://doi.org/10.1093/jnen/nlz116
Publikováno v:
Genes
Volume 12
Issue 7
Genes, Vol 12, Iss 1008, p 1008 (2021)
Volume 12
Issue 7
Genes, Vol 12, Iss 1008, p 1008 (2021)
Genome-wide association studies (GWAS) have identified immune-related genes as risk factors for Alzheimer’s disease (AD), including TREM2 and CD33, frequently passing a stringent false-discovery rate. These genes either encode or signal through imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6952c6950dd495ee274143224032f9
https://pubmed.ncbi.nlm.nih.gov/34208838
https://pubmed.ncbi.nlm.nih.gov/34208838