Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Benjamin C, Creekmore"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Ultrastructure of human brain tissue has traditionally been examined using electron microscopy (EM) following fixation, staining, and sectioning, which limit resolution and introduce artifacts. Alternatively, cryo-electron tomography (cryo-E
Externí odkaz:
https://doaj.org/article/20e181ba98f141b9b9c17f2c03db17c6
Autor:
Samuel J. Pellock, Benjamin C. Creekmore, William G. Walton, Naimee Mehta, Kristen A. Biernat, Andrew P. Cesmat, Yamuna Ariyarathna, Zachary D. Dunn, Bo Li, Jian Jin, Lindsey I. James, Matthew R. Redinbo
Publikováno v:
ACS Central Science, Vol 4, Iss 7, Pp 868-879 (2018)
Externí odkaz:
https://doaj.org/article/b1ff0ac7279e4be986216bba4649e130
Autor:
Benjamin C. Creekmore, Josh H. Gray, William G. Walton, Kristen A. Biernat, Michael S. Little, Yongmei Xu, Jian Liu, Raad Z. Gharaibeh, Matthew R. Redinbo
Publikováno v:
mSystems, Vol 4, Iss 4 (2019)
ABSTRACT Gut microbial β-glucuronidase (GUS) enzymes play important roles in drug efficacy and toxicity, intestinal carcinogenesis, and mammalian-microbial symbiosis. Recently, the first catalog of human gut GUS proteins was provided for the Human M
Externí odkaz:
https://doaj.org/article/b1c52767175148238815600a394ac356
Publikováno v:
J Neuropathol Exp Neurol
Neurodegenerative diseases are characterized by the accumulation of misfolded proteins. This protein aggregation suggests that abnormal proteostasis contributes to aging-related neurodegeneration. A better fundamental understanding of proteins that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9838b0904ebe282b3f761a9bba168287
https://doi.org/10.1093/jnen/nlab029
https://doi.org/10.1093/jnen/nlab029
Autor:
Benjamin C. Creekmore, Jeffrey Roach, Raad Z. Gharaibeh, M. Andrea Azcarate-Peril, William G. Walton, Ian D. Wilson, Matthew R. Redinbo, Jonathan R. Swann, R. Balfour Sartor, S.J. Pellock, Aadra P. Bhatt, Bret D. Wallace, Jose R. Roques, David B. Darr, Scott J. Bultman, Marine P.M. Letertre, Sean T. Bailey, Stephanie A. Montgomery, Kristen A. Biernat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cancer chemotherapy often causes side effects that require modulations in dosing, which then reduce anticancer efficacy. Here, we show that targeted inhibition of gut bacterial enzymes alleviates key stages of gut epithelial damage cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93892ba246e6d26c5938d33d034add6d
http://europepmc.org/articles/PMC7132129
http://europepmc.org/articles/PMC7132129
Publikováno v:
J Neuropathol Exp Neurol
Neurogenerative diseases are characterized by diverse protein aggregates with a variety of microscopic morphologic features. Although ultrastructural studies of human neurodegenerative disease tissues have been conducted since the 1960s, only recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b190feb78848a8f4130a59a19bf261
https://pubmed.ncbi.nlm.nih.gov/33970243
https://pubmed.ncbi.nlm.nih.gov/33970243
Autor:
S.J. Pellock, Ashutosh Tripathy, Kristen A. Biernat, Benjamin C. Creekmore, Lance Stewart, Jian Liu, Yongmei Xu, Dariana Torres-Rivera, Matthew R. Redinbo, William G. Walton
Publikováno v:
Journal of Biological Chemistry. 293:18559-18573
The glycoside hydrolases encoded by the human gut microbiome play an integral role in processing a variety of exogenous and endogenous glycoconjugates. Here we present three structurally and functionally distinct β-glucuronidase (GUS) glycoside hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53185d79b605b346e322095faa4e3578
https://doi.org/10.1074/jbc.ra118.005414
https://doi.org/10.1074/jbc.ra118.005414
Autor:
Andrew P. Cesmat, Benjamin C. Creekmore, Matthew R. Redinbo, Jian Jin, Bo Li, William G. Walton, Naimee Mehta, S.J. Pellock, Lindsey I. James, Yamuna Ariyarathna, Zachary D. Dunn, Kristen A. Biernat
Publikováno v:
ACS Central Science, Vol 4, Iss 7, Pp 868-879 (2018)
ACS Central Science
ACS Central Science
Microbial β-glucuronidases (GUSs) cause severe gut toxicities that limit the efficacy of cancer drugs and other therapeutics. Selective inhibitors of bacterial GUS have been shown to alleviate these side effects. Using structural and chemical biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4767c15aa52c7d4b443e3ac5f2b8e299
https://doaj.org/article/b1ff0ac7279e4be986216bba4649e130
https://doaj.org/article/b1ff0ac7279e4be986216bba4649e130
Autor:
Dariana Torres-Rivera, Benjamin C. Creekmore, Matthew R. Redinbo, Zachary D. Dunn, Bo Li, S.J. Pellock, Grace Bergan, Ashutosh Tripathy, William G. Walton, Samantha M. Ervin
Publikováno v:
Journal of molecular biology. 431(5)
The human gut microbiota encodes β-glucuronidases (GUSs) that play key roles in health and disease via the metabolism of glucuronate-containing carbohydrates and drugs. Hundreds of putative bacterial GUS enzymes have been identified by metagenomic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba232c21d77625797a92fe4e5b11c9c
https://pubmed.ncbi.nlm.nih.gov/30658055
https://pubmed.ncbi.nlm.nih.gov/30658055
Autor:
Samuel J, Pellock, William G, Walton, Kristen A, Biernat, Dariana, Torres-Rivera, Benjamin C, Creekmore, Yongmei, Xu, Jian, Liu, Ashutosh, Tripathy, Lance J, Stewart, Matthew R, Redinbo
Publikováno v:
The Journal of biological chemistry. 293(48)
The glycoside hydrolases encoded by the human gut microbiome play an integral role in processing a variety of exogenous and endogenous glycoconjugates. Here we present three structurally and functionally distinct β-glucuronidase (GUS) glycoside hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98be9a6adbcf1aedc654b697a7c4d75c
https://pubmed.ncbi.nlm.nih.gov/30301767
https://pubmed.ncbi.nlm.nih.gov/30301767