Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Benjamin Buller"'
Autor:
Samantha Calderazzo, Margaret Covert, Diego De Alba, Bethany E. Bowley, Monica A. Pessina, Douglas L. Rosene, Benjamin Buller, Maria Medalla, Tara L. Moore
Publikováno v:
IBRO Neuroscience Reports, Vol 13, Iss , Pp 243-254 (2022)
Reorganization of motor circuits in the cortex and corticospinal tract are thought to underlie functional recovery after cortical injury, but the mechanisms of neural plasticity that could be therapeutic targets remain unclear. Recent work from our g
Externí odkaz:
https://doaj.org/article/411891bc93264325be240c46a967bde9
Autor:
Li Zhang, Robin Schwartz-Byrne, Steven Gertz, Matthew McGuire, Colleen Woodhouse, Brianna Powell, Min Wei, Chao Li, Clare B. Billing, Todd A. Verdoorn, Leslie Lam, Tom J. Parry, Benjamin Buller, Zheng Gang Zhang, David Poulsen, Michael Chopp
Publikováno v:
Stroke. 53:3455-3464
Background: Ischemic stroke affects about 700 000 patients per year in the United States, and to date, there are no effective pharmacological agents that promote recovery. Here, we studied the pharmacokinetics, pharmacodynamics, and efficacy of NTS-1
Autor:
Ted Bambakidis, Benjamin Buller, Aaron M. Williams, Simone E. Dekker, Zachary Pickell, Umar F. Bhatti, Ben E. Biesterveld, Yongqing Li, Baoling Liu, Hasan B. Alam
Publikováno v:
Shock. 57:281-290
BACKGROUND Cell-based therapies using mesenchymal stem cell derived extracellular vesicles (EVs) improve neurologic outcomes in animal models of traumatic brain injury (TBI), stroke, and hemorrhage. Using a porcine 7-day survival model of TBI and hem
Autor:
Yongqing Li, Yuzi Tian, Umar F. Bhatti, Benjamin Buller, Michael T. Kemp, Zhenyu Wu, Ranganath G. Kathawate, Gerald A Higgins, Glenn K. Wakam, Baoling Liu, Simone E. Dekker, Ben E. Biesterveld, Hasan B. Alam, Aaron M. Williams
Publikováno v:
Journal of Trauma and Acute Care Surgery. 89:536-543
BACKGROUND We have shown that administration of mesenchymal stem cell-derived exosomes (single dose given within 1 hour) in models of traumatic brain injury (TBI) and hemorrhagic shock is neuroprotective. The precise mechanisms responsible for the ne
Autor:
Umar F. Bhatti, Zhenyu Wu, Claire A Vercruysse, Yuzi Tian, Glenn K. Wakam, Yongqing Li, Simone E. Dekker, Hasan B. Alam, Ali Z. Siddiqui, Benjamin Buller, Zachary Pickell, Aaron M. Williams, Baoling Liu, Michael T. Kemp, Kiril Chtraklin, Ben E. Biesterveld
Publikováno v:
Journal of Trauma and Acute Care Surgery. 89:388-396
BACKGROUND Early single-dose treatment with human mesenchymal stem cell-derived exosomes promotes neuroprotection and promotes blood-brain barrier integrity in models of traumatic brain injury (TBI) and hemorrhagic shock (HS) in swine. The impact of
Autor:
Veronica Go, Maria Medalla, Samantha M. Calderazzo, Diego De Alba, Tara L. Moore, Wayne Chang, Joseph W. Goodliffe, Alexandra Tsolias, Douglas L. Rosene, Dhruba Pathak, Benjamin Buller, Monica A. Pessina
Publikováno v:
J Neurosci
Functional recovery after cortical injury, such as stroke, is associated with neural circuit reorganization, but the underlying mechanisms and efficacy of therapeutic interventions promoting neural plasticity in primates are not well understood. Bone
Autor:
Ranganath G. Kathawate, Gerald A. Higgins, Ben E. Biesterveld, Ali Z. Siddiqui, Benjamin Buller, Hasan B. Alam, Umar F. Bhatti, Nathan J. Graham, Jordana F. Brown, Anuska V. Andjelkovic, Aaron M. Williams, Simone E. Dekker, Kiril Chtraklin
Publikováno v:
Journal of Trauma and Acute Care Surgery. 88:207-218
BACKGROUND Administration of human mesenchymal stem cell (MSC)-derived exosomes can enhance neurorestoration in models of traumatic brain injury (TBI) and hemorrhagic shock (HS). The impact of early treatment with MSC-derived exosomes on brain injury
Autor:
Monica A. Pessina, Tara L. Moore, Zheng Gang Zhang, Benjamin Buller, Maria Medalla, Veronica Go, Bethany G E Bowley, Douglas L. Rosene, Michael Chopp, Seth P. Finklestein
Publikováno v:
GeroScience. 42:1-17
Cortical injury, such as injuries after stroke or age-related ischemic events, triggers a cascade of degeneration accompanied by inflammatory responses that mediate neurological deficits. Therapeutics that modulate such neuroinflammatory responses in
Publikováno v:
Nature Reviews Neurology. 15:193-203
Stroke is a leading cause of disability worldwide, and brain injuries devastate patients and their families, but currently no drugs on the market promote neurological recovery. Limited spontaneous recovery of function as a result of brain remodelling
Autor:
Panpan Chang, Aaron M. Williams, Ye Xiong, Michael Chopp, Yanlu Zhang, Zheng Gang Zhang, Benjamin Buller, Umar F. Bhatti, Kiril Chtraklin, Hasan B. Alam, Vahagn C. Nikolian, Jordana F. Brown, Ihab Halaweish, Isabel S. Dennahy
Publikováno v:
Journal of Neurotrauma. 36:54-60
Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes have demonstrated promise in small animal models of neurologic injury. To investigate the