Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Benjamin B. Land"'
Publikováno v:
Addiction Neuroscience, Vol 1, Iss , Pp 100005- (2022)
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR). KOR agonists have been shown
Externí odkaz:
https://doaj.org/article/45a8d0a3757e42a4a025b8bf96b2a8d3
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It has previously been shown that
Externí odkaz:
https://doaj.org/article/87439fc26b8f43e89872c5f4d00e3224
Autor:
Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enha
Externí odkaz:
https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d73
Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Thr
Externí odkaz:
https://doaj.org/article/21c16e99692b4eceb09f0193512c4e5b
Autor:
Simar Singh, Dennis Sarroza, Anthony English, Maya McGrory, Ao Dong, Larry Zweifel, Benjamin B. Land, Yulong Li, Michael R. Bruchas, Nephi Stella
IntroductionThe endocannabinoids (eCBs), 2-arachidonoylglycerol (2-AG) and arachidonoyl ethanolamine (AEA), are produced by separate enzymatic pathways, activate cannabinoid receptors with distinct pharmacology, and differentially regulate pathophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::772b32979bf4c11c07d570b47330ec25
https://doi.org/10.1101/2023.03.03.531053
https://doi.org/10.1101/2023.03.03.531053
Autor:
Rachelle Tran, Antony D. Abraham, Benjamin B. Land, Phillip R. Silva, Harrison M. Fontaine, John F. Neumaier, Carlie Neiswanger, Charles Chavkin
Publikováno v:
Neuropsychopharmacology. 47:891-901
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. In male mice, we fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bc2eb371987f642bd379c4d32e63266
https://doi.org/10.1038/s41386-021-01178-0
https://doi.org/10.1038/s41386-021-01178-0
Autor:
Simar Singh, Dennis Sarroza, Anthony English, Dale Whittington, Ao Dong, Mario van der Stelt, Yulong Li, Larry Zweifel, Michael R. Bruchas, Benjamin B. Land, Nephi Stella
The most abundant endocannabinoid (eCB) in the brain, 2-arachidonoyl glycerol (2-AG), is hydrolyzed by α/β-hydrolase domain containing 6 (ABHD6); yet how ABHD6 controls stimuli-dependent increases in 2-AG production is unknown. To explore this ques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::295123c761f565082cde3055d24f6f3a
https://doi.org/10.1101/2022.05.18.492553
https://doi.org/10.1101/2022.05.18.492553
Autor:
Giuseppe D'Agostino, David J Lyons, Claudia Cristiano, Luke K Burke, Joseph C Madara, John N Campbell, Ana Paula Garcia, Benjamin B Land, Bradford B Lowell, Ralph J Dileone, Lora K Heisler
Publikováno v:
eLife, Vol 5 (2016)
The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated. We reveal that a subset of NTS neurons co
Externí odkaz:
https://doaj.org/article/1b559606d11a4687b7660ef13fb4452f
Autor:
Benjamin B. Land, Rachelle Tran, Phillip R. Silva, Antony D. Abraham, Charles Chavkin, Carlie Neiswanger, Harrison M. Fontaine, John F. Neumaier
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b3335943291ba42d631e06a5bac34f
https://doi.org/10.1101/2021.06.27.450100
https://doi.org/10.1101/2021.06.27.450100
Autor:
Harrison M, Fontaine, Phillip R, Silva, Carlie, Neiswanger, Rachelle, Tran, Antony D, Abraham, Benjamin B, Land, John F, Neumaier, Charles, Chavkin
Publikováno v:
Neuropsychopharmacology
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. In male mice, we fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cba4801e8914c9afb9fdfd93badec8f
https://pubmed.ncbi.nlm.nih.gov/34564712
https://pubmed.ncbi.nlm.nih.gov/34564712