Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Benjamin Audit"'
Autor:
Bertrand Theulot, Laurent Lacroix, Jean-Michel Arbona, Gael A. Millot, Etienne Jean, Corinne Cruaud, Jade Pellet, Florence Proux, Magali Hennion, Stefan Engelen, Arnaud Lemainque, Benjamin Audit, Olivier Hyrien, Benoît Le Tallec
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Theulot et al. introduce NanoForkSpeed, a nanopore sequencing-based method to map individual replication fork velocities on entire genomes. NFS shows that fork speed is uniform across yeast chromosomes except for a marked slowdown at pausing sites.
Externí odkaz:
https://doaj.org/article/b8e2f80d57284f0b8386e98104ca5aad
Autor:
Magali Hennion, Jean-Michel Arbona, Laurent Lacroix, Corinne Cruaud, Bertrand Theulot, Benoît Le Tallec, Florence Proux, Xia Wu, Elizaveta Novikova, Stefan Engelen, Arnaud Lemainque, Benjamin Audit, Olivier Hyrien
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-25 (2020)
Abstract Genome replication mapping methods profile cell populations, masking cell-to-cell heterogeneity. Here, we describe FORK-seq, a nanopore sequencing method to map replication of single DNA molecules at 200-nucleotide resolution. By quantifying
Externí odkaz:
https://doaj.org/article/207b69b66bc4499fb532f23fff185faf
DNA replication stands as one of the fundamental biological processes crucial for cellular functioning. Recent experimental developments enable the study of replication dynamics at the single-molecule level for complete genomes, facilitating a deeper
Externí odkaz:
http://arxiv.org/abs/2404.00824
Autor:
Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers
Publikováno v:
eLife, Vol 10 (2021)
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and f
Externí odkaz:
https://doaj.org/article/44e8901c580f40a8879fd1df94d25925
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-13 (2017)
Abstract Background Structural interaction frequency matrices between all genome loci are now experimentally achievable thanks to high-throughput chromosome conformation capture technologies. This ensues a new methodological challenge for computation
Externí odkaz:
https://doaj.org/article/786d8e67c2f7441dae2a1c254de0549c
Publikováno v:
eLife, Vol 7 (2018)
The time-dependent rate [Formula: see text] of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving interaction between origins and limiting firi
Externí odkaz:
https://doaj.org/article/3c251189e5da4515b9c1ff99bf76398f
Autor:
Evgeniya Gerasimova-Chechkina, Brian Toner, Zach Marin, Benjamin Audit, Stephane Roux, Francoise Argoul, Andre Khalil, Olga Gileva, Oleg Naimark, Alain Arneodo
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
There is growing evidence that the microenvironment surrounding a tumor plays a special role in cancer development and cancer therapeutic resistance. Tumors arise from the dysregulation and alteration of both the malignant cells and their environment
Externí odkaz:
https://doaj.org/article/3bd0dcbb7d7b4da49ea0b08989249286
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 2, p e1003969 (2015)
Epigenetic regulation of the replication program during mammalian cell differentiation remains poorly understood. We performed an integrative analysis of eleven genome-wide epigenetic profiles at 100 kb resolution of Mean Replication Timing (MRT) dat
Externí odkaz:
https://doaj.org/article/365953e6bb5b4adaa2bd30d94bc8637d
Autor:
Franck Picard, Jean-Charles Cadoret, Benjamin Audit, Alain Arneodo, Adriana Alberti, Christophe Battail, Laurent Duret, Marie-Noelle Prioleau
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004282 (2014)
The duplication of mammalian genomes is under the control of a spatiotemporal program that orchestrates the positioning and the timing of firing of replication origins. The molecular mechanisms coordinating the activation of about [Formula: see text]
Externí odkaz:
https://doaj.org/article/2b2dbd3d4d3348faaebaba9e754e7573
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 10, p e1003233 (2013)
Advances in genomic studies have led to significant progress in understanding the epigenetically controlled interplay between chromatin structure and nuclear functions. Epigenetic modifications were shown to play a key role in transcription regulatio
Externí odkaz:
https://doaj.org/article/a2624bbde4a5496d9187375133752573