Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Benjamin Alexander Mayes"'
Autor:
David D. Pascoe, John D. Hayler, Alistair Stewart, Erica Vit, Jingyang Wang, Etridge Stephen K, Celine Bret, Alan Ironmonger, Elaine Smith, Neil Hodnett, Jerome F. Hayes, Adel Moussa, Benjamin Alexander Mayes, Jonathan Stanway
Publikováno v:
Organic Process Research & Development. 22:207-211
Amidation of indole 2-carboxylate 1 with ammonia gas via the imidazolide 2 gave GSK2248761A API 3, which was in development for the treatment of HIV. Three significant impurities, namely the phosphinic acid 4, the N-acyl urea 8, and the indoloyl carb
Autor:
Elodie Rosinovsky, Catherine Caillet, Chiara Musiu, Jingyang Wang, Marie-Pierre Lioure, Arlène Roland, Luana Vargiu, Jocelyn Jakubik, Alistair Stewart, Michel Liuzzi, Richard Storer, Stéphanie Bot, Daniel Da Costa, Sébastien Maldonado, Barbara Poddesu, David Standring, Christophe Claude Parsy, Cyril B. Dousson, Christophe Trochet, Séverine Bonaric, Francois-Rene Alexandre, Maria Seifer, Adel Moussa, Benjamin Alexander Mayes, Agnès Amador, Luke Hubbard, Thierry Convard
Publikováno v:
Journal of Medicinal Chemistry. 59:1891-1898
Here, we describe the design, synthesis, biological evaluation, and identification of a clinical candidate non-nucleoside reverse transcriptase inhibitors (NNRTIs) with a novel aryl-phospho-indole (APhI) scaffold. NNRTIs are recommended components of
Autor:
Roger Rush, Charlie Bu, Steven Smith, Gasparac Rahela, Marita Larsson Cohen, Kusum Sachdev Gupta, Hassan Rashidzadeh, Adel Moussa, Xin-Ru Pan-Zhou, Steven S. Good, Benjamin Alexander Mayes, Sanjeev Bhadresa
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 41:567-574
IDX184 is a phosphoramidate prodrug of 2′-methylguanosine-5′-monophosphate, developed to treat patients infected with hepatitis C virus. A mass balance study of radiolabeled IDX184 and pharmacokinetic studies of IDX184 in portal vein-cannulated m
Autor:
Roberta Glynn, Steven Mathieu, David Bauer, Jeevanandam Arumugasamy, Jie Li, Jingyang Wang, Alistair Stewart, Alan Becker, Jinsoo Lim, Elodie Rosinovsky, F. Patrick McGarry, Narayan Chaudhuri, G. Mark Latham, Erkan Baloglu, Adrien F. Soret, Kannan Arunachalam, Jia Liu, Adel Moussa, Benjamin Alexander Mayes
Publikováno v:
Organic Process Research & Development. 19:520-530
A scalable process is described for the synthesis of 2′-C-methylguanosine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase. The route features the
Autor:
Alistair Stewart, Zofia Komsta, Benjamin Alexander Mayes, Adel Moussa, Alexander Yurek-George, Laura Wallis, Andrew J. Tyrrell, Alexander C. Weymouth-Wilson, Montserrat Shelbourne
Publikováno v:
Tetrahedron Letters. 55:6216-6219
Synthesis of a novel 1′,2′-oxetane-uridine bearing a 2′-C-methyl substituent, [1-(1′,3′-O-anhydro-3′-C-methyl-β- d -psicofuranosyl)uracil], is described. Key to its construction was the use of 6-O-(p-toluoyl)-1,2:3,4-di-O-isopropylidene-
Autor:
Elodie Rosinovsky, Narayan Chaudhuri, Benjamin Alexander Mayes, Christophe Trochet, Steven Mathieu, G. Mark Latham, Alistair Stewart, Adel Moussa, Jie Li, Jeevanandam Arumugasamy, Alan Becker, Erkan Baloglu, F. Patrick McGarry, Jingyang Wang, David Bauer
Publikováno v:
Organic Process Research & Development. 18:717-724
A synthetic process for 2′-C-methylcytidine-5′-[2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)thio]ethyl-N-benzylphosphoramidate], a nucleotide prodrug inhibitor of hepatitis C virus NS5B polymerase, is described. The route developed was demonstrated on
Autor:
Xinghua Wu, Jia Liu, Catherine Caillet, Aurelien E. Salanson, Kannan Arunachalam, David Bauer, Jeevanandam Arumugasamy, Elodie Rosinovsky, Jingyang Wang, G. Mark Latham, Benjamin Alexander Mayes, Roberta Glynn, Alistair Stewart, Jinsoo Lim, Alan Becker, Adrien F. Soret, Adel Moussa
Publikováno v:
Organic Process Research & Development. 17:811-828
A novel assembly of two structurally related 14-membered ring macrocyclic hepatitis C virus protease inhibitors is presented. Key to their successful construction was an ultimate ring-closing metathesis step on the respective highly functionalized di
Autor:
George W. J. Fleet, Benjamin Alexander Mayes, David J. Watkin, Lieven Simon, Christopher W. G. Ansell
Hydrogenation of linear ω-azido-pentafluorophenyl esters gives cyclic peptides containing 14-, 21-, 28-, 35-, 56- and 70-membered ring lactams from oligomers derived from ε-amino acids in excellent to moderate yields with a lack of racemisation dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732df6b6412a2bb15b4dea558da8825a
https://doi.org/10.1016/j.tetlet.2003.10.103
https://doi.org/10.1016/j.tetlet.2003.10.103
Autor:
Alison A. Edwards, George E. Tranter, Benjamin Alexander Mayes, George W. J. Fleet, Mark P. Watterson, Christopher W. G. Ansell, Rebecca J. E. Stetz
Circular dichroism studies on a series of linear oligomers derived from a protected 6-amino-6-deoxy-D-galactonate (an ε-amino acid) indicated a predisposition to form a rigid structure in solution, which is comparable to a β-sheet composed of L-ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0477b7f827f1f443bc43489c885655a8
https://ora.ox.ac.uk/objects/uuid:801e6113-e26a-4fb1-a2dd-c47ab6ff3767
https://ora.ox.ac.uk/objects/uuid:801e6113-e26a-4fb1-a2dd-c47ab6ff3767
Autor:
Montserrat Shelbourne, Benjamin Alexander Mayes, Alistair Stewart, Alexander Yurek-George, Alexander C. Weymouth-Wilson, Laura Wallis, Andrew J. Tyrrell, Zofia Komsta, Adel Moussa
Publikováno v:
Organic Letters. 16:4878-4880
The synthesis of the novel 2',3'-cyclopropane nucleoside 3'-deoxy-3'-C-hydroxymethyl-2',3'-methylene-uridine is described. Stereoselective construction of the cyclopropane ring was achieved via Simmons-Smith cyclopropanation of a benzyl protected sil