Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Benjamin A. Story"'
Autor:
Ashutosh Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars M. Steinmetz, Thomas Vaccari, Hamed Jafar-Nejad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Intestinal barrier dysfunction leads to inflammation and associated metabolic changes. However, the relative impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. H
Externí odkaz:
https://doaj.org/article/fc75a5d2d921427790e61a8613dba176
Autor:
Lars Velten, Benjamin A. Story, Pablo Hernández-Malmierca, Simon Raffel, Daniel R. Leonce, Jennifer Milbank, Malte Paulsen, Aykut Demir, Chelsea Szu-Tu, Robert Frömel, Christoph Lutz, Daniel Nowak, Johann-Christoph Jann, Caroline Pabst, Tobias Boch, Wolf-Karsten Hofmann, Carsten Müller-Tidow, Andreas Trumpp, Simon Haas, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Leukaemic stem cells drive acute myeloid leukaemia (AML) progression and relapse but they are incompletely characterized. Here, the authors combine single-cell transcriptomics and clonal tracking using nuclear and mitochondrial somatic variants to di
Externí odkaz:
https://doaj.org/article/7f3244539bc54da0bc5ec3fba0f6edbe
Autor:
Theophilus T. Tettey, Xin Gao, Wanqing Shao, Hua Li, Benjamin A. Story, Alex D. Chitsazan, Robert L. Glaser, Zach H. Goode, Christopher W. Seidel, Ronald C. Conaway, Julia Zeitlinger, Marco Blanchette, Joan W. Conaway
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3770-3779.e7 (2019)
Summary: FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro. In this repo
Externí odkaz:
https://doaj.org/article/c81b7cddae3447a483588e1979bbe1c7
Autor:
Marco Blanchette, Benjamin A. Story, Wanqing Shao, Ronald C. Conaway, Theophilus T. Tettey, Julia Zeitlinger, Robert L. Glaser, Hua Li, Joan W. Conaway, Zach H. Goode, Xin Gao, Alex D. Chitsazan, Christopher Seidel
Publikováno v:
Cell Reports, Vol 27, Iss 13, Pp 3770-3779.e7 (2019)
Summary: FACT (facilitates chromatin transcription) is an evolutionarily conserved histone chaperone that was initially identified as an activity capable of promoting RNA polymerase II (Pol II) transcription through nucleosomes in vitro. In this repo
Autor:
Christoph Lutz, Simon Haas, Pablo Hernández-Malmierca, Lars Velten, Caroline Pabst, Daniel Nowak, Tobias Boch, Chelsea Szu-Tu, Benjamin A. Story, Aykut Demir, Robert Frömel, Wolf-Karsten Hofmann, Jennifer Milbank, Malte Paulsen, Daniel R. Leonce, Carsten Müller-Tidow, Simon Raffel, Andreas Trumpp, Lars M. Steinmetz, Johann-Christoph Jann
Publikováno v:
Nature Communications, 12 (1)
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. In acute myeloid leukemia (AML), leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ec4fb26a46903d0f84cbb2b6145fba
https://hdl.handle.net/20.500.11850/474268
https://hdl.handle.net/20.500.11850/474268
Autor:
Brendan Bell, P. Richard Harrigan, Johanne Toutant, Marco Blanchette, David S. Grierson, Ahalya Balachandran, Benjamin A. Story, Lulzim Shkreta, Peter K. Cheung, Alan Cochrane, Emmanuelle Wilhelm, Benoit Chabot
Publikováno v:
Nucleic Acids Research
We recently identified the 4-pyridinone-benzisothiazole carboxamide compound 1C8 as displaying strong anti-HIV-1 potency against a variety of clinical strains in vitro. Here we show that 1C8 decreases the expression of HIV-1 and alters splicing event
Autor:
Hayato Kawakami, William F. Mueller, Yuki Masahara-Negishi, Yoshihiro Kamada, Takehiko Yokomizo, Lars M. Steinmetz, Yoshihiro Akimoto, Petra Jakob, Sandra Clauder-Münster, Benjamin A. Story, Tadashi Suzuki, Haruhiko Fujihira, Senthil K. Radhakrishnan, Eiji Miyoshi, Hyeon-Cheol Lee, Hiroto Hirayama
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1866(3)
The cytoplasmic peptide:N-glycanase (Ngly1) is a de-N-glycosylating enzyme that cleaves N-glycans from misfolded glycoproteins and is involved in endoplasmic reticulum-associated degradation. The recent discovery of NGLY1-deficiency, which causes sev
Autor:
Kathryn E Hall, Jungeun Park, Hua Li, Xing Ma, Perera Anoja, Kazue Ishihara, Benjamin A. Story, Jeffrey S. Haug, Allison Peak, Marco Blanchette, Ting Xie
Publikováno v:
Life Science Alliance. 2:e201800211
Piwi-interacting RNAs (piRNAs) are important for repressing transposable elements (TEs) and modulating gene expression in germ cells, thereby maintaining genome stability and germ cell function. Although they are also important for maintaining germli
Autor:
Allison Peak, Perera Anoja, Kate Hall, Su Wang, Xing Ma, Ying Zhang, Madelaine Gogol, Trieu Do, Xiaoqing Song, Xiujuan Zhu, Ting Xie, Marco Blanchette, Yingying Han, Benjamin A. Story
Publikováno v:
Developmental Cell. 41:157-169.e5
Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and earl