Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Benjamin A. Pibworth"'
Autor:
Elisabeth Mortimer-Cassen, Kathryn Costelloe, Robert M. Owen, R. Ian Storer, Philip H. Milliken, Magda Bictash, Gianna Toschi, Andrew Pike, Hannah J. Pearce, Emma Impey, Benjamin A. Pibworth, Caroline L. Benn, Emma Armstrong, David C. Blakemore
Publikováno v:
MedChemComm. 7:1587-1595
Elevated serum uric acid levels can lead to gout which remains an area of unmet medical need. Following an unexpected clinical uricosuric effect observed with a sulfonamide compound, PF-05089771 (9), subsequently attributed to weak URAT1 inhibition,
Autor:
Gareth W. Harbottle, Daniel Laity, Stuart Field, Kenneth John Butcher, Benjamin A. Pibworth, Adam T. Gillmore, Christian J. Ngono, Steven M. Denton, Roger M. Howard
Publikováno v:
Organic Process Research & Development. 15:1192-1200
The convergent scale-up synthesis of two complex TRPV1 antagonists to support exploratory toxicology studies is described. Both compounds contain three chiral centers introduced by asymmetric synthesis with chiral control being critical for the succe