Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Benjamin A. Horenstein"'
Publikováno v:
Molecular Pharmacology. 60:1365-1374
Inhibition of neuronal nicotinic receptors can be regulated by the presence of specific amino acids in the subunit second transmembrane domain (TM2) domain. We show that the incorporation of a mutant 4 subunit, which contains sequence from the muscle
Publikováno v:
Biochemistry. 39:5902-5910
Trypanosoma cruzi trans-sialidase catalyzes a novel reaction that involves the transfer of sialic acid between host and parasite glycoconjugates. In this paper, we report kinetic isotope effect studies on recombinant trans-sialidase. β-Dideuterium a
Publikováno v:
Tetrahedron Letters. 41:2801-2804
A facile asymmetric synthesis of N -alkyl-3,4-dihydroxy-5-alkylpiperidines has been developed, which is based on an asymmetric alkylation reaction of the SAMP hydrazone of N -BOC piperidinone.
Autor:
Michael Bruner, Benjamin A. Horenstein
Publikováno v:
Journal of the American Chemical Society. 120:1357-1362
Solvolysis of CMP N-acetyl neuraminate (CMP-NeuAc) in 1.8 M acetate buffer at pH 5 containing 0.9 M azide results in the formation of both anomers of 2-deoxy-2-azido N-acetyl neuraminic acid in addition to N-acetyl neuraminic acid as determined by 1H
Autor:
Benjamin A. Horenstein
Publikováno v:
Journal of the American Chemical Society. 119:1101-1107
An ab initio investigation of a pyranosyl oxocarbenium ion with an α-carboxylate substituent is presented. Geometry, energetics, and isotope effects have been determined in the gas phase and with s...
Autor:
Steven D. Schwartz, Paul J. Berti, Kathleen A. Rising, David W. Parkin, David J. Merkler, Vern L. Schramm, Benjamin A. Horenstein, Johannes Scheuring, Carey K. Bagdassarian, Paul C. Kline
Publikováno v:
International Journal of Quantum Chemistry. 60:1805-1813
rn A procedure is described which leads to experimentally based models for the transitionstate structures of enzyme-catalyzed reactions. Substrates for an enzymic reaction are synthesized with isotopically enriched atoms at every position in which bo
Autor:
Michael Bruner, Benjamin A. Horenstein
Publikováno v:
Journal of the American Chemical Society. 118:10371-10379
An investigation of the mechanism of solvolysis of CMP-N-acetyl neuraminate (CMP-NeuAc) is presented that includes synthesis of a family of isotopically labeled CMP-NeuAc's, use of new methodology ...
Publikováno v:
Journal of Biological Chemistry. 269:18259-18262
Publikováno v:
Tetrahedron Letters. 34:7213-7216
The first members of a new class of N-glycohydrolase transition state analogue inhibitors, 1,4-dideoxy-1,4-imino-1-(S)-phenyl-D-ribitol, 1, and 1,4-dideoxy-1,4-imino-1-(S)-(4-imidazolyl)-D-ribitol, 2, have been synthesized. These compounds represent
Publikováno v:
Tetrahedron Letters. 42:2451-2453
A new class of glycosyltransferase inhibitor has been designed and synthesized. The designed inhibitors 3a / 3b provide conformational mimicry of the transition state in sialyltransfer reactions. The key synthetic steps involve a Meinwald rearrangeme