Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Benjamin A. Himes"'
Autor:
Luiza Mendonça, Dapeng Sun, Jiying Ning, Jiwei Liu, Abhay Kotecha, Mateusz Olek, Thomas Frosio, Xiaofeng Fu, Benjamin A. Himes, Alex B. Kleinpeter, Eric O. Freed, Jing Zhou, Christopher Aiken, Peijun Zhang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Mendonça et al. determine the structures of both in vitro assemblies of the HIV structural precursor protein Gag and Gag viral-like particles (VLPs) to 4.2 Å and 4.5 Å resolutions, using cryo-electron tomography and subtomogram averaging. This stu
Externí odkaz:
https://doaj.org/article/9ab2d7c26554447ba2a91fac3949925b
Autor:
Jiying Ning, Gonca Erdemci-Tandogan, Ernest L. Yufenyuy, Jef Wagner, Benjamin A. Himes, Gongpu Zhao, Christopher Aiken, Roya Zandi, Peijun Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Two competing models—disassembly/reassembly and displacive—have been proposed for how immature spherical HIV virions transform into mature particles with conical cores. Here the authors provide evidence that both disassembly/reassembly and displa
Externí odkaz:
https://doaj.org/article/e6fb1da96d5249b4968508b5d2a47b9e
Autor:
Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid t
Externí odkaz:
https://doaj.org/article/3b563f433dd146d4b7f6b78da7c03c54
Autor:
Cecile Riviere-Cazaux, Karishma Rajani, Masum Rahman, Juhee Oh, Desmond A. Brown, Jaclyn F. White, Benjamin T. Himes, Ignacio Jusue-Torres, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, William F. Elmquist, Terry C. Burns
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background Microdialysis is a technique that can be utilized to sample the interstitial fluid of the central nervous system (CNS), including in primary malignant brain tumors known as gliomas. Gliomas are mainly accessible at the time of sur
Externí odkaz:
https://doaj.org/article/b01726b9a3c24b95811a6ea5c664f995
Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
Autor:
Cecile Riviere-Cazaux, Lucas P. Carlstrom, Karishma Rajani, Amanda Munoz-Casabella, Masum Rahman, Ali Gharibi-Loron, Desmond A. Brown, Kai J. Miller, Jaclyn J. White, Benjamin T. Himes, Ignacio Jusue-Torres, Samar Ikram, Seth C. Ransom, Renee Hirte, Ju-Hee Oh, William F. Elmquist, Jann N. Sarkaria, Rachael A. Vaubel, Moses Rodriguez, Arthur E. Warrington, Sani H. Kizilbash, Terry C. Burns
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The extracellular microenvironment modulates glioma behaviour. It remains unknown if blood-brain barrier disruption merely reflects or functionally supports glioma aggressiveness. We utilised intra-operative microdialysis to sample the extra
Externí odkaz:
https://doaj.org/article/df7819129fee4a19804cd898e7b157b6
Publikováno v:
eLife, Vol 12 (2023)
Previously we showed that 2D template matching (2DTM) can be used to localize macromolecular complexes in images recorded by cryogenic electron microscopy (cryo-EM) with high precision, even in the presence of noise and cellular background (Lucas et
Externí odkaz:
https://doaj.org/article/760b2bfbb0ec4000ae7c1f47e12c6eb4
Autor:
Zachariah P. Tritz, Katayoun Ayasoufi, Delaney M. Wolf, Carley A. Owens, Courtney S. Malo, Benjamin T. Himes, Cori E. Fain, Emma N. Goddery, Lila T. Yokanovich, Fang Jin, Michael J. Hansen, Ian F. Parney, Chensu Wang, Kelly D. Moynihan, Darrell J. Irvine, K. Dane Wittrup, Rosa M. Diaz Marcano, Richard G. Vile, Aaron J. Johnson
Publikováno v:
Cancer Immunology Research. :OF1-OF14
Glioblastoma (GBM) is the most common malignant brain tumor in adults, responsible for approximately 225,000 deaths per year. Despite preclinical successes, most interventions have failed to extend patient survival by more than a few months. Treatmen
Autor:
Bronwyn A Lucas, Benjamin A Himes, Liang Xue, Timothy Grant, Julia Mahamid, Nikolaus Grigorieff
Publikováno v:
eLife, Vol 10 (2021)
For a more complete understanding of molecular mechanisms, it is important to study macromolecules and their assemblies in the broader context of the cell. This context can be visualized at nanometer resolution in three dimensions (3D) using electron
Externí odkaz:
https://doaj.org/article/95163e83d93a47ad8d5e15d79438f016
Autor:
Panagiotis Kerezoudis, Evangelia N. Kerezoudi, Abdurehman Choudhry, Benjamin T. Himes, Ian F. Parney
Publikováno v:
Neurosurgery. 92:464-471
Autor:
Aaron J. Johnson, Richard G. Vile, Rosa M. Diaz Marcano, K. Dane Wittrup, Darrell J. Irvine, Kelly D. Moynihan, Chensu Wang, Ian F. Parney, Michael J. Hansen, Fang Jin, Lila T. Yokanovich, Emma N. Goddery, Cori E. Fain, Benjamin T. Himes, Courtney S. Malo, Carley A. Owens, Delaney M. Wolf, Katayoun Ayasoufi, Zachariah P. Tritz
Supplemental Figure 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8af07029eab8305dbe3c80548980b1f
https://doi.org/10.1158/2326-6066.22713695.v1
https://doi.org/10.1158/2326-6066.22713695.v1