Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Benjamin A. Harlan"'
Publikováno v:
FASEB J
Nuclear receptor subfamily 1 group D member 1 (NR1D1, also known as Rev-erbα) is a nuclear transcription factor that is part of the molecular clock encoding circadian rhythms and may link daily rhythms with metabolism and inflammation. NR1D1, unlike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bbe754486b68472c3f4ab811032b7f2
https://europepmc.org/articles/PMC9223394/
https://europepmc.org/articles/PMC9223394/
Publikováno v:
Glia
Fatty acid binding proteins (FABPs) are key regulators of lipid metabolism, energy homeostasis and inflammation. They participate in fatty acid metabolism by regulating their uptake, transport and availability of ligands to nuclear receptors. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8760dbdbccadc15c6b2e8aee03b5a6fe
https://doi.org/10.1002/glia.23879
https://doi.org/10.1002/glia.23879
Publikováno v:
FASEB J
Most physiological processes in mammals are subjected to daily oscillations that are governed by a circadian system. The circadian rhythm orchestrates metabolic pathways in a time-dependent manner and loss of circadian timekeeping has been associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6a29fb288e15a0ccd43e0f7070df00
https://doi.org/10.1096/fj.202000386rr
https://doi.org/10.1096/fj.202000386rr
Publikováno v:
Neuropsychopharmacology. 43:2064-2074
Dopamine neurons in the ventral tegmental area (VTA) influence learned behaviors and neuropsychiatric diseases including addiction. The stress peptide corticotrophin-releasing factor (CRF) contributes to relapse to drug and alcohol seeking following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd1aebc129c24c997fc3d5dc48ed860
https://doi.org/10.1038/s41386-018-0106-9
https://doi.org/10.1038/s41386-018-0106-9
Autor:
Kelby M. Killoy, Benjamin A. Harlan, Kristi L. Helke, Marcelo R. Vargas, Mariana Pehar, Jeffrey A. Johnson
Publikováno v:
Experimental Neurology. 302:129-135
Mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons. Several lines of evidence have shown that SOD1 mutations cause ALS th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda11d92b5a3dcecfa8e5051d8ea05a6
https://doi.org/10.1016/j.expneurol.2018.01.004
https://doi.org/10.1016/j.expneurol.2018.01.004
Publikováno v:
Aging (Albany NY)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1335688f445240650cf4630c493a12c4
https://doi.org/10.18632/aging.203085
https://doi.org/10.18632/aging.203085
Autor:
Benjamin A, Harlan, Kelby M, Killoy, Mariana, Pehar, Liping, Liu, Johan, Auwerx, Marcelo R, Vargas
Publikováno v:
Exp Neurol
Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD(+) availability, or increasing the expression of the NAD(+)-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fc6ab337f5f7969f894d3dedae6d5f4
https://pubmed.ncbi.nlm.nih.gov/32014438
https://pubmed.ncbi.nlm.nih.gov/32014438
Sirtuins (SIRTs) are NAD(+)-dependent deacylases that play a key role in transcription, DNA repair, metabolism, and oxidative stress resistance. Increasing NAD(+) availability regulates endogenous SIRT activity, leading to increased resistance to oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa90ab9f0db94f60fe71fd7e67671e1b
https://europepmc.org/articles/PMC6529338/
https://europepmc.org/articles/PMC6529338/
Autor:
Marcelo R. Vargas, Deep Raj Sharma, Mariana Pehar, Benjamin A. Harlan, Gyda C. Beeson, Craig Beeson
Publikováno v:
Journal of Biological Chemistry. 291:10836-10846
Nicotinamide adenine dinucleotide (NAD(+)) participates in redox reactions and NAD(+)-dependent signaling pathways. Although the redox reactions are critical for efficient mitochondrial metabolism, they are not accompanied by any net consumption of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc577185248a2b3eed16440a475553db
https://doi.org/10.1074/jbc.m115.698779
https://doi.org/10.1074/jbc.m115.698779
Autor:
Marcelo R. Vargas, Benjamin A. Harlan, Benjamin A. Neely, Lauren E. Ball, Mariana Pehar, Susana Comte-Walters, Deep Raj Sharma
Publikováno v:
Molecular & Cellular Proteomics. 15:493-505
Astrocytes and neurons form a highly specialized functional unit, and the loss or gain of astrocytic functions can influence the initiation and progression of different neurodegenerative diseases. Neurons depend on the antioxidant protection provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df28627a3b176138fdcbf07a24b13dfe
https://doi.org/10.1074/mcp.m115.049288
https://doi.org/10.1074/mcp.m115.049288