Zobrazeno 1 - 10
of 657
pro vyhledávání: '"Benjamin A. Garcia"'
Autor:
Benjamin A. Nacev, Yakshi Dabas, Matthew R. Paul, Christian Pacheco, Michelle Mitchener, Yekaterina Perez, Yan Fang, Alexey A. Soshnev, Douglas Barrows, Thomas Carroll, Nicholas D. Socci, Samantha C. St. Jean, Sagarika Tiwari, Michael J. Gruss, Sebastien Monette, William D. Tap, Benjamin A. Garcia, Tom Muir, C. David Allis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Dysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. How
Externí odkaz:
https://doaj.org/article/a8ab4f3e792a49f58af3860467b6cc16
Autor:
Victoria S. Frisbie, Hideharu Hashimoto, Yixuan Xie, Francisca N. De Luna Vitorino, Josue Baeza, Tam Nguyen, Zhangerjiao Yuan, Janna Kiselar, Benjamin A. Garcia, Erik W. Debler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase processively produces H3K79me2/me3 through histone H2B mono-ubiquitin interaction, while the kinetoplastid Trypanosoma brucei di-methyltransferase DOT1A and t
Externí odkaz:
https://doaj.org/article/dee92a5dbeef4bc7a7fcd20f4ce671b2
Autor:
Katarzyna B. Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N.L. Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K. Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A. Garcia, Jacek Majewski, Bozena Kaminska, Jakub Mieczkowski
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113707- (2024)
Summary: Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in histone 3 (H3.3 or H3.1) resulting in a lysine-to-methioni
Externí odkaz:
https://doaj.org/article/590589af8239422c9bd340fc8f43c4fa
Autor:
Laura M. Agosto, Michael J. Mallory, Max B. Ferretti, Davia Blake, Keegan S. Krick, Matthew R. Gazzara, Benjamin A. Garcia, Kristen W. Lynch
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112273- (2023)
Summary: Chromatin regulation and alternative splicing are both critical mechanisms guiding gene expression. Studies have demonstrated that histone modifications can influence alternative splicing decisions, but less is known about how alternative sp
Externí odkaz:
https://doaj.org/article/07b7255a22c54daf86da08fcb975ee19
Autor:
Lorna A. Farrelly, Shuangping Zheng, Nadine Schrode, Aaron Topol, Natarajan V. Bhanu, Ryan M. Bastle, Aarthi Ramakrishnan, Jennifer C Chan, Bulent Cetin, Erin Flaherty, Li Shen, Kelly Gleason, Carol A. Tamminga, Benjamin A. Garcia, Haitao Li, Kristen J. Brennand, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Schizophrenia (SZ) is a severe psychiatric disorder; unfortunately, only ~1/3 of patients respond favorably to treatment. Here, the authors reveal hyperacetylation of histone H2A.Z in SZ neurons and postmortem SZ human brain tissues. They further sho
Externí odkaz:
https://doaj.org/article/82c68feb169f4133ac1edea10af43af7
Autor:
Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Scholler, Avery D. Posey, Mark H. O’Hara, Anze Smole, Daniel J. Powell, Benjamin A. Garcia, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I
Externí odkaz:
https://doaj.org/article/5c32458bd77b40989a4cd89c57021223
Autor:
Jacque L. Faylo, Trevor van Eeuwen, Hee Jong Kim, Jose J. Gorbea Colón, Benjamin A. Garcia, Kenji Murakami, David W. Christianson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Substrate channeling can improve biosynthetic efficiency and has been implicated in the reactions of fusicoccadiene synthase. Here, the authors analyze this bifunctional enzyme complex by cryoEM, cross-linking MS and integrative modeling, providing s
Externí odkaz:
https://doaj.org/article/fbb2f4b36b8d4e3eaddd473f28e72330
Autor:
Trevor van Eeuwen, Yoonjung Shim, Hee Jong Kim, Tingting Zhao, Shrabani Basu, Benjamin A. Garcia, Craig D. Kaplan, Jung-Hyun Min, Kenji Murakami
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM struc
Externí odkaz:
https://doaj.org/article/d50d4da2dfcb426987c2cc95413c64ea
Autor:
Marianne C. Kramer, Hee Jong Kim, Kyle R. Palos, Benjamin A. Garcia, Eric Lyons, Mark A. Beilstein, Andrew D. L. Nelson, Brian D. Gregory
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Long non-coding RNAs (lncRNAs) are an increasingly studied group of non-protein coding transcripts with a wide variety of molecular functions gaining attention for their roles in numerous biological processes. Nearly 6,000 lncRNAs have been identifie
Externí odkaz:
https://doaj.org/article/f8c901e7a40e49f3bc97039c662fb966
Autor:
Stefan Steimle, Trevor van Eeuwen, Yavuz Ozturk, Hee Jong Kim, Merav Braitbard, Nur Selamoglu, Benjamin A. Garcia, Dina Schneidman-Duhovny, Kenji Murakami, Fevzi Daldal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Respiratory chains generate the proton motive force used for ATP synthesis. Cryo-EM structures of functional respiratory CIII2CIV supercomplex and native CIII2 from Rhodobacter capsulatus provide insight into CIII2CIV assembly and respiratory electro
Externí odkaz:
https://doaj.org/article/9384e9b4b26945ae8279e5a9af357d23