Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Benjamin A Thuma"'
Publikováno v:
Acta Crystallographica Section E, Vol 66, Iss 6, Pp o1386-o1386 (2010)
In the title compound, C19H21ClOS2, the dithiane ring adopts a chair conformation. The dihedral angle between the benzene rings is 87.88 (4)°. In the crystal, inversion dimmers linked by pairs of C—H...O interactions occur.
Externí odkaz:
https://doaj.org/article/1a7361d6f2554633a9796f8b3970341e
Autor:
Aaron Baldwin, Shawn Cabral, Kris N. Jones, Jeffrey T. Kohrt, Chris Limberakis, Yiyang Liu, Javier Magano, Sebastien Monfette, Asaad Nematalla, Sami Ovaska, David W. Piotrowski, Jared L. Piper, Jeffrey W. Raggon, Benjamin A. Thuma, Liuqing Wei
Publikováno v:
Organic Process Research & Development. 27:854-865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b446554282a8d998077c9e50879f0def
https://doi.org/10.1021/acs.oprd.2c00351
https://doi.org/10.1021/acs.oprd.2c00351
Autor:
Allyn T. Londregan, Karlygash Aitmakhanova, James Bennett, Laura J. Byrnes, Daniel P. Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B. Coffey, João M. Dias, Matthew S. Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F. Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R. Harris, Brett D. Hollingshead, Kilian Huber, Magdalena Korczynska, Kimberly Lapham, Paula M. Loria, Arjun Narayanan, Dafydd R. Owen, Brigitt Raux, Parag V. Sahasrabudhe, Roger B. Ruggeri, Laura Díaz Sáez, Ingrid A. Stock, Benjamin A. Thuma, Andy Tsai, Alison E. Varghese
Publikováno v:
Journal of medicinal chemistry.
A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f200505c5effa14e470509072c0e10b
https://pubmed.ncbi.nlm.nih.gov/36562986
https://pubmed.ncbi.nlm.nih.gov/36562986
Autor:
Ariamala Gopalsamy, Ann E. Aulabaugh, Amey Barakat, Kevin C. Beaumont, Shawn Cabral, Daniel P. Canterbury, Agustin Casimiro-Garcia, Jeanne S. Chang, Ming Z. Chen, Chulho Choi, Robert L. Dow, Olugbeminiyi O. Fadeyi, Xidong Feng, Scott P. France, Roger M. Howard, Jay M. Janz, Jayasankar Jasti, Reema Jasuja, Lyn H. Jones, Amanda King-Ahmad, Kelly M. Knee, Jeffrey T. Kohrt, Chris Limberakis, Spiros Liras, Carlos A. Martinez, Kim F. McClure, Arjun Narayanan, Jatin Narula, Jonathan J. Novak, Thomas N. O’Connell, Mihir D. Parikh, David W. Piotrowski, Olga Plotnikova, Ralph P. Robinson, Parag V. Sahasrabudhe, Raman Sharma, Benjamin A. Thuma, Dipy Vasa, Liuqing Wei, A. Zane Wenzel, Jane M. Withka, Jun Xiao, Hatice G. Yayla
Publikováno v:
Journal of Medicinal Chemistry. 64:326-342
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin (HbS). In the deoxygenated state, polymerization of HbS leads to sickling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fb3aa72d831f7f375af97473787b3a
https://doi.org/10.1021/acs.jmedchem.0c01518
https://doi.org/10.1021/acs.jmedchem.0c01518
Autor:
Shawn D. Doran, Jana Polivkova, James A. Southers, Scott W. Bagley, Kim Huard, Dilinie P. Fernando, Manthena V.S. Varma, David A. Beebe, David J. Edmonds, Robert L. Dow, Benjamin A. Thuma, Collin Crowley, William P. Esler, Trenton T. Ross, David A. Tess, Mark Niosi, Amit S. Kalgutkar, Jeffrey A. Pfefferkorn, Norimitsu Shirai, David A. Griffith, Shawn Cabral, Andrew H. Smith, Gregg D. Cappon, Vincent Mascitti, Matthew S. Dowling, Andre Shavnya, David Price, Ayman El-Kattan, Aaron C. Smith, Yi-an Bi, Spiros Liras, Xiaojing Helen Yang, Cathy Préville
Publikováno v:
Journal of Medicinal Chemistry. 63:10879-10896
Preclinical and clinical data suggest that acetyl-CoA carboxylase (ACC) inhibitors have the potential to rebalance disordered lipid metabolism, leading to improvements in nonalcoholic steatohepatitis (NASH). Consistent with these observations, first-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07da4330450bd15b2bafcbaadc0cc94b
https://doi.org/10.1021/acs.jmedchem.0c00640
https://doi.org/10.1021/acs.jmedchem.0c00640
Autor:
Gang Xing, David Price, Aaron C. Smith, Jayasankar Jasti, Kentaro Futatsugi, Steven B. Coffey, Meihua Tu, Kevin D. Parris, Yan Weng, Dilinie P. Fernando, Kay Ahn, Matthew S. Dowling, Kim Huard, Jayvardhan Pandit, Jeffrey A. Pfefferkorn, Benjamin A. Thuma, Brian Raymer, Tim F. Ryder, Gregory J. Tesz, Andre Shavnya, Amit S. Kalgutkar, Jun Zhou, Hanna M. Wisniewska, Jemy A. Gutierrez, John D. Knafels, Magee Thomas Victor, Ingrid A. Stock, Sylvie Perez, Tsai Andy
Publikováno v:
Journal of medicinal chemistry. 63(22)
Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resistance. Ketohexokinase (KHK) converts fructose to fruct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c107a413095d612ee94dff2632747e3a
https://pubmed.ncbi.nlm.nih.gov/32910646
https://pubmed.ncbi.nlm.nih.gov/32910646
Autor:
Liuqing Wei, Jun Xiao, Joseph S. Warmus, Jeffrey R. Chabot, Robert Dullea, Christopher T. Salatto, David W. Piotrowski, Benjamin A. Thuma, Donna N. Petersen, Chris Limberakis, Julien Genovino, Steven B. Coffey, Michael W. Bolt, Kim F. McClure, Kevin D. Hesp, Spiros Liras, Jamie H. D. Cate, Nathanael G. Lintner, Allyn T. Londregan, Gary Erik Aspnes, Benjamin Reidich
Publikováno v:
Journal of Medicinal Chemistry. 61:5704-5718
The optimization of a new class of small molecule PCSK9 mRNA translation inhibitors is described. The potency, physicochemical properties, and off-target pharmacology associated with the hit compound (1) were improved by changes to two regions of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46075104e513dd56e96e55dc41b689b9
https://doi.org/10.1021/acs.jmedchem.8b00650
https://doi.org/10.1021/acs.jmedchem.8b00650
Autor:
Daniel W. Widlicka, Nathan E. Genung, Jana Polivkova, Daniel W. Kung, Wiglesworth Kristin, Thomas Andrew Brandt, Jun Xiao, Matthew S. Dowling, Yingxin Zhang, Paul M. Herrinton, David J. Edmonds, Todd Zahn, Ka Ning Yip, Colin R. Rose, Qifang Li, Jane Panteleev, Shawn Cabral, Andre Shavnya, Nandell F. Keene, John D. Weaver, Benjamin A. Thuma, Michael Herr, Ian Edmonds, Gary Erik Aspnes, Guoqiang Wang, Philip D. Dent, Dilinie P. Fernando, Aaron C. Smith, Michael G. Vetelino, Sophie Y. Lavergne, Edward L. Conn
Publikováno v:
Organic Process Research & Development. 22:681-696
Indole acids 1, 2, and 3 are potent 5′-adenosine monophosphate-activated protein kinase (AMPK) activators for the potential treatment of diabetic nephropathy. Compounds 1–3 were scaled to supply material for preclinical studies, and indole 3 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b628a560af69b1edadd146b3a36513be
https://doi.org/10.1021/acs.oprd.8b00059
https://doi.org/10.1021/acs.oprd.8b00059
Autor:
Ariana Hirsh, Robert Dullea, Meihua Tu, Spiros Liras, Joan Compte Barrón, Kris A. Borzilleri, Nannan Ma, Rima Mendonsa, Justin Bellenger, Romain Rouet, Lorena de Oñate, Xidong Feng, Jennifer A. Doudna, Nathanael G. Lintner, David M. Rubitski, Benjamin A. Thuma, Marc D. Roy, Alison H. Varghese, Kim F. McClure, Ross C. Wilson, Thomas J. McLellan, Hanna M. Wisniewska, James E. Finley, Boris A. Chrunyk, Vincent Mascitti, Kaihong Zhou, Kevin D. Hesp
Publikováno v:
Journal of the American Chemical Society, vol 140, iss 21
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
Rouet, Romain; Thuma, Benjamin A; Roy, Marc D; Lintner, Nathanael G; Rubitski, David M; Finley, James E; et al.(2018). Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.. Journal of the American Chemical Society, 140(21), 6596-6603. doi: 10.1021/jacs.8b01551. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/61k3t664
CRISPR-Cas RNA-guided endonucleases hold great promise for disrupting or correcting genomic sequences through site-specific DNA cleavage and repair. However, the lack of methods for cell- and tissue-selective delivery currently limits both research a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af967c5dc058dcd0e0a6cfe05eb8b81
https://doi.org/10.1021/jacs.8b01551
https://doi.org/10.1021/jacs.8b01551
Autor:
John D. Knafels, David Price, Matthew Gorgoglione, Aaron C. Smith, Kevin D. Parris, Jemy A. Gutierrez, Magee Thomas Victor, Erik Alphie Lachapelle, Yan Weng, Edward L. Conn, Jeffrey A. Pfefferkorn, Jane M. Withka, Kim Huard, Matthew S. Dowling, Timothy A. Subashi, Trenton T. Ross, Benjamin A. Thuma, Kris A. Borzilleri, Paul A. Amor, Jeffrey S. Culp, Meihua Tu, Sylvie Perez, Jayvardhan Pandit, Andre Shavnya, Boris A. Chrunyk, Gang Xing, John D. Weaver, Yang Cong, Kay Ahn, David A. Beebe, Brian Raymer, Gregory J. Tesz, Steven B. Coffey
Publikováno v:
Journal of Medicinal Chemistry. 60:7835-7849
Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b654213309542f5b2a14a9d23ebc4df8
https://doi.org/10.1021/acs.jmedchem.7b00947
https://doi.org/10.1021/acs.jmedchem.7b00947