Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Benjamin A Diner"'
Autor:
Benjamin A Diner, Tuo Li, Todd M Greco, Marni S Crow, John A Fuesler, Jennifer Wang, Ileana M Cristea
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 2, Pp 1-22 (2015)
Abstract The human PYHIN proteins, AIM2, IFI16, IFIX, and MNDA, are critical regulators of immune response, transcription, apoptosis, and cell cycle. However, their protein interactions and underlying mechanisms remain largely uncharacterized. Here,
Externí odkaz:
https://doaj.org/article/662dd0511dec4367852700987d9e96a7
Publikováno v:
Viruses, Vol 5, Iss 7, Pp 1607-1632 (2013)
Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly,
Externí odkaz:
https://doaj.org/article/54bf770ad8c54f1f9949314c5b2b0c30
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT The human interferon-inducible protein IFI16 is an important antiviral factor that binds nuclear viral DNA and promotes antiviral responses. Here, we define IFI16 dynamics in space and time and its distinct functions from the DNA sensor cycl
Externí odkaz:
https://doaj.org/article/19a3a4e9d9874345856f732570023d05
Autor:
Ren Song, Orkide O. Koyuncu, Todd M. Greco, Benjamin A. Diner, Ileana M. Cristea, Lynn W. Enquist
Publikováno v:
mBio, Vol 7, Iss 1 (2016)
ABSTRACT Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the inf
Externí odkaz:
https://doaj.org/article/9b87fab9a02049da9e10275212c26540
Autor:
Chang-Sik Oh, Guido Sessa, Robyn Roberts, Georgy Popov, Gregory B. Martin, Kerry F. Pedley, Sarah R. Hind, Benjamin A. Diner, Bharat Bhusan Majhi, Matthew J. Szarzanowicz, Dianiris Luciano-Rosario
Publikováno v:
Molecular Plant-Microbe Interactions®. 32:1496-1507
The molecular mechanisms acting between host recognition of pathogen effectors by nucleotide-binding leucine-rich repeat receptor (NLR) proteins and mitogen-activated protein kinase (MAPK) signaling cascades are unknown. MAPKKKα (M3Kα) activates MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f2a5f6c7f759cb27af8381e6288683
https://doi.org/10.1094/mpmi-05-19-0121-r
https://doi.org/10.1094/mpmi-05-19-0121-r
Publikováno v:
Journal of Biological Chemistry. 290:26412-26421
Detecting pathogenic DNA by intracellular receptors termed "sensors" is critical toward galvanizing host immune responses and eliminating microbial infections. Emerging evidence has challenged the dogma that sensing of viral DNA occurs exclusively in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2b2fc460e1f5336fe0eea5ef44f13c
https://doi.org/10.1074/jbc.r115.652289
https://doi.org/10.1074/jbc.r115.652289
Publikováno v:
Molecular & Cellular Proteomics. 14:2341-2356
The interferon-inducible protein IFI16 has emerged as a critical antiviral factor and sensor of viral DNA. IFI16 binds nuclear viral DNA, triggering expression of antiviral cytokines during infection with herpesviruses. The knowledge of the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41613410735e8aa844b5a5ced2476275
https://doi.org/10.1074/mcp.m114.047068
https://doi.org/10.1074/mcp.m114.047068
Publikováno v:
Annual Review of Virology
In recent years, mass spectrometry has emerged as a core component of fundamental discoveries in virology. As a consequence of their coevolution, viruses and host cells have established complex, dynamic interactions that function either in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6064f797998f40a6d5e08ac87049a674
Autor:
Todd M. Greco, Benjamin A. Diner, Orkide O. Koyuncu, Ileana M. Cristea, Lynn W. Enquist, Ren Song
Publikováno v:
mBio
mBio, Vol 7, Iss 1 (2016)
mBio, Vol 7, Iss 1, p e02145-15 (2016)
mBio, Vol 7, Iss 1 (2016)
mBio, Vol 7, Iss 1, p e02145-15 (2016)
Infection by alphaherpesviruses, including herpes simplex virus (HSV) and pseudorabies virus (PRV), typically begins at epithelial surfaces and continues into the peripheral nervous system (PNS). Inflammatory responses are induced at the infected per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a01c9de12cff902bbd45621c6c72d0
https://pubmed.ncbi.nlm.nih.gov/26838720
https://pubmed.ncbi.nlm.nih.gov/26838720
Publikováno v:
Proceedings of the National Academy of Sciences. 109:10558-10563
Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses. Despite being pred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e5b08ffa76ab89e4d698a4f122f6a2
https://doi.org/10.1073/pnas.1203447109
https://doi.org/10.1073/pnas.1203447109