Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Benjamin A, Alman"'
Autor:
Ga I. Ban, Vijitha Puviindran, Yu Xiang, Puvi Nadesan, Jackie Tang, Jianhong Ou, Nicholas Guardino, Makoto Nakagawa, MaKenna Browne, Asjah Wallace, Koji Ishikawa, Eijiro Shimada, John T. Martin, Yarui Diao, David G. Kirsch, Benjamin A. Alman
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110187- (2024)
Summary: Intratumoral heterogeneity is common in cancer, particularly in sarcomas like undifferentiated pleomorphic sarcoma (UPS), where individual cells demonstrate a high degree of cytogenic diversity. Previous studies showed that a small subset of
Externí odkaz:
https://doaj.org/article/144907bc7fea4fa9bea54a2af2dc7bf3
Autor:
Kan Ito, Yoshihiro Nishida, Shunsuke Hamada, Koki Shimizu, Tomohisa Sakai, Bisei Ohkawara, Benjamin A. Alman, Atsushi Enomoto, Kunihiro Ikuta, Hiroshi Koike, Jiarui Zhang, Kinji Ohno, Shiro Imagama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Anticancer drugs and molecular targeted therapies are used for refractory desmoid-type fibromatosis (DF), but occasionally cause severe side effects. The purpose of this study was to identify an effective drug with fewer side effects against
Externí odkaz:
https://doaj.org/article/b103c9d9c681484a9d7276bc4c0c3415
Autor:
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112578- (2023)
Summary: Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, sug
Externí odkaz:
https://doaj.org/article/9cb3c9ca6c2240379dd61634e40c1c8c
Autor:
Sinthu Pathmanapan, Olga Ilkayeva, John T. Martin, Adrian Kwan Ho Loe, Hongyuan Zhang, Guo-Fang Zhang, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background Majority of chondrosarcomas are associated with a number of genetic alterations, including somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes, but the downstream effects of these mutated enzymes on cellular meta
Externí odkaz:
https://doaj.org/article/748bddafda024403a2e65a48d6597085
Autor:
Yuning Jackie Tang, Vijitha Puviindran, Yu Xiang, Yasuhito Yahara, Hongyuan Zhang, Puviindran Nadesan, Yarui Diao, David G. Kirsch, Benjamin A. Alman
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Sarcomas contain a subpopulation of tumor-propagating cells (TPCs) with enhanced tumor-initiating and self-renewal properties. However, it is unclear whether the TPC phenotype in sarcomas is stable or a dynamic cell state that can derive from non-TPC
Externí odkaz:
https://doaj.org/article/4b6a34a6fcb2465f925fb7d800fc9aa1
Publikováno v:
Anesthesia & Analgesia. 136:1055-1063
Autor:
Mushriq Al-Jazrawe, Steven Xu, Raymond Poon, Qingxia Wei, Joanna Przybyl, Sushama Varma, Matt van de Rijn, Benjamin A. Alman
Publikováno v:
Cancer Research Communications. 3:697-708
The interaction between neoplastic and stromal cells within a tumor mass plays an important role in cancer biology. However, it is challenging to distinguish between tumor and stromal cells in mesenchymal tumors because lineage-specific cell surface
Autor:
Linda Vi, Gurpreet S. Baht, Erik J. Soderblom, Heather Whetstone, Qingxia Wei, Bridgette Furman, Vijitha Puviindran, Puviindran Nadesan, Matthew Foster, Raymond Poon, James P. White, Yasuhito Yahara, Adeline Ng, Tomasa Barrientos, Marc Grynpas, M. Arthur Mosely, Benjamin A. Alman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The rate of repair declines with age; however, exposure to young circulations can rejuvenate fracture repair, but how this is accomplished is unknown. Here, the authors identify proteins, including low-density lipoprotein receptor-related protein 1 (
Externí odkaz:
https://doaj.org/article/56adb114e6924a34bf6b3b26daebff26
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
A third of the population sustains a bone fracture, and the pace of fracture healing slows with age. The slower pace of repair is responsible for the increased morbidity in older individuals who sustain a fracture. Bone healing progresses through ove
Externí odkaz:
https://doaj.org/article/12607c5a66544f899cafdda510532e21
Autor:
Shintaro Ide, Yasuhito Yahara, Yoshihiko Kobayashi, Sarah A Strausser, Kana Ide, Anisha Watwe, Shengjie Xu-Vanpala, Jamie R Privratsky, Steven D Crowley, Mari L Shinohara, Benjamin A Alman, Tomokazu Souma
Publikováno v:
eLife, Vol 9 (2020)
Renal macrophages represent a highly heterogeneous and specialized population of myeloid cells with mixed developmental origins from the yolk-sac and hematopoietic stem cells (HSC). They promote both injury and repair by regulating inflammation, angi
Externí odkaz:
https://doaj.org/article/4ed4b11be84440c6ad8f20ff6ae3ad22