Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Benjamin, Stauch"'
Autor:
Anastasiia Gusach, Aleksandra Luginina, Egor Marin, Rebecca L. Brouillette, Élie Besserer-Offroy, Jean-Michel Longpré, Andrii Ishchenko, Petr Popov, Nilkanth Patel, Taku Fujimoto, Toru Maruyama, Benjamin Stauch, Margarita Ergasheva, Daria Romanovskaia, Anastasiia Stepko, Kirill Kovalev, Mikhail Shevtsov, Valentin Gordeliy, Gye Won Han, Vsevolod Katritch, Valentin Borshchevskiy, Philippe Sarret, Alexey Mishin, Vadim Cherezov
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Cysteinyl leukotriene G protein-coupled receptors CysLT1 and CysLT2 regulate pro-inflammatory responses associated with allergic disorders. Here, authors describe four crystal structures of CysLT2R in complex with three dual CysLT1R/CysLT2R antagonis
Externí odkaz:
https://doaj.org/article/c54160b2896f4e3f9bcd8053dc21a8c7
Autor:
Andrii Ishchenko, Benjamin Stauch, Gye Won Han, Alexander Batyuk, Anna Shiriaeva, Chufeng Li, Nadia Zatsepin, Uwe Weierstall, Wei Liu, Eriko Nango, Takanori Nakane, Rie Tanaka, Kensuke Tono, Yasumasa Joti, So Iwata, Isabel Moraes, Cornelius Gati, Vadim Cherezov
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 1106-1119 (2019)
Rational structure-based drug design (SBDD) relies on the availability of a large number of co-crystal structures to map the ligand-binding pocket of the target protein and use this information for lead-compound optimization via an iterative process.
Externí odkaz:
https://doaj.org/article/4ed362ab387b4cc5b84904da4feed3df
Autor:
Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch
Publikováno v:
eLife, Vol 9 (2020)
Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new liga
Externí odkaz:
https://doaj.org/article/ae3b26d29f104825bba96ae407a6e98e
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 12, Pp 2348-2358 (2015)
Lipases (EC 3.1.1.3) are ubiquitous hydrolases for the carboxyl ester bond of water-insoluble substrates, such as triacylglycerols, phospholipids, and other insoluble substrates, acting in aqueous as well as in low-water media, thus being of consider
Externí odkaz:
https://doaj.org/article/61dfb3ac0a00400fb8646832c0473ad1
Publikováno v:
Nat Rev Methods Primers
Nature Reviews Methods primers
Nature Reviews Methods primers
With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial crystallography techniques for macromolecular structure determination have emerged. Serial femtosecond crystallography (SFX) and related methods provide possibilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6484026df0f438cabb286c142b88c5c
https://europepmc.org/articles/PMC9833121/
https://europepmc.org/articles/PMC9833121/
Publikováno v:
Elife, 10, pp. 1-22
eLife
Elife, 10, 1-22
eLife, Vol 10 (2021)
eLife
Elife, 10, 1-22
eLife, Vol 10 (2021)
Stimulus repetition reduces neuronal responses in sensory areas, while leaving perceptual fidelity and behavioral performance intact. Visual gamma-band activity decreases for few stimulus repetitions in humans, yet increases for many repetitions in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b887be231a3f7b14b425af32b0c510
https://doi.org/10.7554/eLife.68240
https://doi.org/10.7554/eLife.68240
Autor:
Raphaël, Bolteau, Romain, Duroux, Amélie, Laversin, Brandon, Vreulz, Anna, Shiriaeva, Benjamin, Stauch, Gye Won, Han, Vadim, Cherezov, Nicolas, Renault, Amélie, Barczyk, Séverine, Ravez, Mathilde, Coevoet, Patricia, Melnyk, Maxime, Liberelle, Saïd, Yous
Publikováno v:
European journal of medicinal chemistry. 241
The past fifty years have been marked by the surge of neurodegenerative diseases. Unfortunately, current treatments are only symptomatic. Hence, the search for new and innovative therapeutic targets for curative treatments becomes a major challenge.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9dbcd2e0b44d5188113542cf70cf8484
https://pubmed.ncbi.nlm.nih.gov/35933788
https://pubmed.ncbi.nlm.nih.gov/35933788
Publikováno v:
FEBS J
The long-anticipated high-resolution structures of the human melatonin G protein-coupled receptors MT(1) and MT(2), involved in establishing and maintaining circadian rhythm, were obtained in complex with two melatonin analogs and two approved anti-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a754167277ce644771c66257063811
https://doi.org/10.1111/febs.15128
https://doi.org/10.1111/febs.15128
Autor:
Uwe Weierstall, Wei Liu, Rie Tanaka, Anna Shiriaeva, Yasumasa Joti, Gye Won Han, Isabel Moraes, Alexander Batyuk, Eriko Nango, Nadia A. Zatsepin, Chufeng Li, So Iwata, Kensuke Tono, Vadim Cherezov, Benjamin Stauch, Takanori Nakane, Cornelius Gati, Andrii Ishchenko
Publikováno v:
IUCrJ, Vol 6, Iss 6, Pp 1106-1119 (2019)
IUCrJ
IUCrJ
A method is presented for efficient co-crystal structure determination for G protein-coupled receptors taking advantage of serial femtosecond crystallography.
Rational structure-based drug design (SBDD) relies on the availability of a large numb
Rational structure-based drug design (SBDD) relies on the availability of a large numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d4459dd90c32df4607398134c8ebcb
http://scripts.iucr.org/cgi-bin/paper?S2052252519013137
http://scripts.iucr.org/cgi-bin/paper?S2052252519013137