Epigenomic analysis of KLF1 haploinsufficiency in primary human erythroblasts

Autor: Steven Heshusius, Laura Grech, Nynke Gillemans, Rutger W. W. Brouwer, Xander T. den Dekker, Wilfred F. J. van IJcken, Benjamin Nota, Alex E. Felice, Thamar B. van Dijk, Marieke von Lindern, Joseph Borg, Emile van den Akker, Sjaak Philipsen

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Haploinsufficiency for the erythroid-specific transcription factor KLF1 is associated with hereditary persistence of fetal hemoglobin (HPFH). Increased HbF ameliorates the symptoms of β-hemoglobinopathies and downregulation of KLF1 activity

Externí odkaz: https://doaj.org/article/c05d644c68534f3f9075683f486793e0

Iron metabolism in critically ill patients developing anemia of inflammation: a case control study

Autor: Margit Boshuizen, Jan M. Binnekade, Benjamin Nota, Kirsten van de Groep, Olaf L. Cremer, Pieter R. Tuinman, Janneke Horn, Marcus J. Schultz, Robin van Bruggen, Nicole P. Juffermans, Molecular Diagnosis and Risk Stratification of Sepsis (MARS) Consortium

Publikováno v: Annals of Intensive Care, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Background Anemia occurring as a result of inflammatory processes (anemia of inflammation, AI) has a high prevalence in critically ill patients. Knowledge on changes in iron metabolism during the course of AI is limited, hampering the develo

Externí odkaz: https://doaj.org/article/11cc6d2455714a0e8ab2bfcb6e54df89

Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8+ T Cells in the Lungs

Autor: Felix M. Behr, Natasja A. M. Kragten, Thomas H. Wesselink, Benjamin Nota, Rene A. W. van Lier, Derk Amsen, Regina Stark, Pleun Hombrink, Klaas P. J. M. van Gisbergen

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Tissue-resident memory CD8+ T (TRM) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection. CD8+ TRM cells within the skin and the small intestine are long-lived and maintained inde

Externí odkaz: https://doaj.org/article/d505b02166104b0ea42a24ef254d41bb

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Autor: Benjamin Nota, Jan Voorberg, Anastasia Gangaev, Maartje van den Biggelaar, Martin de Boer, Marije Kat, Maaike Schillemans, Jurjen Westeneng, Menno Hofman, Floris P. J. van Alphen, Ruben Bierings, Coert Margadant

Publikováno v: Research and Practice in Thrombosis and Haemostasis, 3(4), 718-732. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 4, Pp 718-732 (2019)
Research and practice in thrombosis and haemostasis, 3(4), 718-732. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis

textabstractBackground: Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs). In the absence of VWF, angiogenic and inflammatory mediators that are cos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4eb9887e1d8ea6b8fcc367d775f4bfd
https://doi.org/10.1002/rth2.12242

Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation

Autor: Jana Koers, Theo Rispens, Pleuni Ooijevaar-de Heer, Benjamin Nota, Gestur Vidarsson, Ninotska I. L. Derksen, Fleur S. van de Bovenkamp

Publikováno v: Journal of immunology (Baltimore, Md., 202(8), 2220-2228. American Association of Immunologists

Abs can acquire N-linked glycans in their V regions during Ag-specific B cell responses. Among others, these N-linked glycans can affect Ag binding and Ab stability. Elevated N-linked glycosylation has furthermore been associated with several B cell�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515dc15b5363715895654406530987ed
https://doi.org/10.4049/jimmunol.1801622