Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC

Autor: Konstantinos Dimitriadis, Jan Meis, Hermann Neugebauer, Kristian Barlinn, Bernhard Neumann, Georg Gahn, Piergiorgio Lochner, Benjamin Knier, Sarah Lindemann, Kurt Wolfram Sühs, Kristina Szabo, Thomas Pfefferkorn, Ingo Schirotzek, Tobias Freilinger, Bassa Burc, Albrecht Günther, Matthias Wittstock, Patrick Schramm, Gernot Reimann, Jana Godau, Gabor Nagy, Fatima B. Koenig, Fabian Essig, Hartwig Klinker, Christian Hartmann, Moritz L. Schmidbauer, Tim Steinberg, Lora Lefterova, Christina Klose, Julian Bösel, for the IGNITE study group

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)

Abstract Background Neurologic manifestations are increasingly reported in patients with coronavirus disease 2019 (COVID-19). Yet, data on prevalence, predictors and relevance for outcome of neurological manifestations in patients requiring intensive

Externí odkaz: https://doaj.org/article/010404c81c5943d08ffa6f23d888dce5

Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS

Autor: Till F. M. Andlauer, Jenny Link, Dorothea Martin, Malin Ryner, Christina Hermanrud, Verena Grummel, Michael Auer, Harald Hegen, Lilian Aly, Christiane Gasperi, Benjamin Knier, Bertram Müller-Myhsok, Poul Erik Hyldgaard Jensen, Finn Sellebjerg, Ingrid Kockum, Tomas Olsson, Marc Pallardy, Sebastian Spindeldreher, Florian Deisenhammer, Anna Fogdell-Hahn, Bernhard Hemmer, on behalf of the ABIRISK consortium

Publikováno v: BMC Medicine, Vol 18, Iss 1, Pp 1-23 (2020)

Abstract Background Upon treatment with biopharmaceuticals, the immune system may produce anti-drug antibodies (ADA) that inhibit the therapy. Up to 40% of multiple sclerosis patients treated with interferon β (IFNβ) develop ADA, for which a geneti

Externí odkaz: https://doaj.org/article/17f0b4a115a9411898d869c49bd392a4

Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis

Autor: Bhagteshwar Singh, Suzannah Lant, Sofia Cividini, Jonathan W. S. Cattrall, Lynsey C. Goodwin, Laura Benjamin, Benedict D. Michael, Ayaz Khawaja, Aline de Moura Brasil Matos, Walid Alkeridy, Andrea Pilotto, Durjoy Lahiri, Rebecca Rawlinson, Sithembinkosi Mhlanga, Evelyn C. Lopez, Brendan F. Sargent, Anushri Somasundaran, Arina Tamborska, Glynn Webb, Komal Younas, Yaqub Al Sami, Heavenna Babu, Tristan Banks, Francesco Cavallieri, Matthew Cohen, Emma Davies, Shalley Dhar, Anna Fajardo Modol, Hamzah Farooq, Jeffrey Harte, Samuel Hey, Albert Joseph, Dileep Karthikappallil, Daniel Kassahun, Gareth Lipunga, Rachel Mason, Thomas Minton, Gabrielle Mond, Joseph Poxon, Sophie Rabas, Germander Soothill, Marialuisa Zedde, Konstantin Yenkoyan, Bruce Brew, Erika Contini, Lucette Cysique, Xin Zhang, Pietro Maggi, Vincent van Pesch, Jérome Lechien, Sven Saussez, Alex Heyse, Maria Lúcia Brito Ferreira, Cristiane N. Soares, Isabel Elicer, Laura Eugenín-von Bernhardi, Waleng Ñancupil Reyes, Rong Yin, Mohammed A. Azab, Foad Abd-Allah, Ahmed Elkady, Simon Escalard, Jean-Christophe Corvol, Cécile Delorme, Pierre Tattevin, Kévin Bigaut, Norbert Lorenz, Daniel Hornuss, Jonas Hosp, Siegbert Rieg, Dirk Wagner, Benjamin Knier, Paul Lingor, Andrea Sylvia Winkler, Athena Sharifi-Razavi, Shima T. Moein, SeyedAhmad SeyedAlinaghi, Saeidreza JamaliMoghadamSiahkali, Mauro Morassi, Alessandro Padovani, Marcello Giunta, Ilenia Libri, Simone Beretta, Sabrina Ravaglia, Matteo Foschi, Paolo Calabresi, Guido Primiano, Serenella Servidei, Nicola Biagio Mercuri, Claudio Liguori, Mariangela Pierantozzi, Loredana Sarmati, Federica Boso, Silvia Garazzino, Sara Mariotto, Kimani N. Patrick, Oana Costache, Alexander Pincherle, Frederikus A. Klok, Roger Meza, Verónica Cabreira, Sofia R. Valdoleiros, Vanessa Oliveira, Igor Kaimovsky, Alla Guekht, Jasmine Koh, Eva Fernández Díaz, José María Barrios-López, Cristina Guijarro-Castro, Álvaro Beltrán-Corbellini, Javier Martínez-Poles, Alba María Diezma-Martín, Maria Isabel Morales-Casado, Sergio García García, Gautier Breville, Matteo Coen, Marjolaine Uginet, Raphaël Bernard-Valnet, Renaud Du Pasquier, Yildiz Kaya, Loay H. Abdelnour, Claire Rice, Hamish Morrison, Sylviane Defres, Saif Huda, Noelle Enright, Jane Hassell, Lucio D’Anna, Matthew Benger, Laszlo Sztriha, Eamon Raith, Krishna Chinthapalli, Ross Nortley, Ross Paterson, Arvind Chandratheva, David J. Werring, Samir Dervisevic, Kirsty Harkness, Ashwin Pinto, Dinesh Jillella, Scott Beach, Kulothungan Gunasekaran, Ivan Rocha Ferreira Da Silva, Krishna Nalleballe, Jonathan Santoro, Tyler Scullen, Lora Kahn, Carla Y. Kim, Kiran T. Thakur, Rajan Jain, Thirugnanam Umapathi, Timothy R. Nicholson, James J. Sejvar, Eva Maria Hodel, The Brain Infections Global COVID-Neuro Network Study Group, Catrin Tudur Smith, Tom Solomon

Publikováno v: PLoS ONE, Vol 17, Iss 6 (2022)

Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 p

Externí odkaz: https://doaj.org/article/095733b27c4d4df5a2a5be6cdb896396

Retinal ganglion cell loss is associated with future disability worsening in early relapsing–remitting multiple sclerosis

Autor: Josephine Wauschkuhn, Gilberto Solorza Buenrostro, Lilian Aly, Susanna Asseyer, Rebecca Wicklein, Julia Maria Hartberger, Klemens Ruprecht, Mark Mühlau, Tanja Schmitz‐Hübsch, Claudia Chien, Achim Berthele, Alexander U. Brandt, Thomas Korn, Friedemann Paul, Bernhard Hemmer, Hanna G. Zimmermann, Benjamin Knier

Publikováno v: European Journal of Neurology. 30:982-990

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::661d70306856c41d57af0665507fba58
https://doi.org/10.1111/ene.15681

Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties

Autor: Chittappen K. Prajeeth, Julius Kronisch, Reza Khorooshi, Benjamin Knier, Henrik Toft-Hansen, Viktoria Gudi, Stefan Floess, Jochen Huehn, Trevor Owens, Thomas Korn, Martin Stangel

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)

Abstract Background Autoreactive Th1 and Th17 cells are believed to mediate the pathology of multiple sclerosis in the central nervous system (CNS). Their interaction with microglia and astrocytes in the CNS is crucial for the regulation of the neuro

Externí odkaz: https://doaj.org/article/72608284b2aa4bc49552822b1e54d240