Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Benjamin, Chain"'
Autor:
Yuta Nagano, Benjamin Chain
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
T cell receptors (TR) underpin the diversity and specificity of T cell activity. As such, TR repertoire data is valuable both as an adaptive immune biomarker, and as a way to identify candidate therapeutic TR. Analysis of TR repertoires relies heavil
Externí odkaz:
https://doaj.org/article/3783e02a9d7a4efb824dccb1f2504b1b
Autor:
Rowan Howell, Matthew A. Clarke, Ann-Kathrin Reuschl, Tianyi Chen, Sean Abbott-Imboden, Mervyn Singer, David M. Lowe, Clare L. Bennett, Benjamin Chain, Clare Jolly, Jasmin Fisher
Publikováno v:
npj Digital Medicine, Vol 5, Iss 1, Pp 1-13 (2022)
Abstract The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The urgent need for effective and affordable COVID-19 treatments calls for repurposing combinations of approved drugs. The challenge is to identify which combi
Externí odkaz:
https://doaj.org/article/138f70666aaf4bca914664c7e630f7d8
Autor:
Lata Govada, Emmanuel Saridakis, Sean C. Kassen, Ahmad Bin-Ramzi, Rhodri Marc Morgan, Benjamin Chain, John R. Helliwell, Naomi E. Chayen
Publikováno v:
IUCrJ, Vol 8, Iss 4, Pp 678-683 (2021)
C-C chemokine receptor 5 (CCR5) is a major co-receptor molecule used by HIV-1 to enter cells. This led to the hypothesis that stimulating an antibody response would block HIV with minimal toxicity. Here, X-ray crystallographic studies of the anti-CCR
Externí odkaz:
https://doaj.org/article/9d9a11fc926f453ebb082e66a0cece04
Autor:
Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background There is an urgent need to develop biomarkers that stratify risk of bacterial infection in order to support antimicrobial stewardship in emergency hospital admissions. Methods We used computational machine learning to derive a rul
Externí odkaz:
https://doaj.org/article/f49351239a2f427ab2056944955526c8
Autor:
Charlotte Manisty, Thomas Alexander Treibel, Melanie Jensen, Amanda Semper, George Joy, Rishi K Gupta, Teresa Cutino-Moguel, Mervyn Andiapen, Jessica Jones, Stephen Taylor, Ashley Otter, Corrina Pade, Joseph Gibbons, Jason Lee, Joanna Bacon, Steve Thomas, Chris Moon, Meleri Jones, Dylan Williams, Jonathan Lambourne, Marianna Fontana, Daniel M Altmann, Rosemary Boyton, Mala Maini, Aine McKnight, Benjamin Chain, Mahdad Noursadeghi, James C Moon
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103259- (2021)
Background: SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to evaluate dynamic changes in antibody levels are required to identify the time ho
Externí odkaz:
https://doaj.org/article/31bf5280b63b4318ae172879a741e59b
Autor:
Peter C de Greef, Theres Oakes, Bram Gerritsen, Mazlina Ismail, James M Heather, Rutger Hermsen, Benjamin Chain, Rob J de Boer
Publikováno v:
eLife, Vol 9 (2020)
The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using an accurate quantitative sequen
Externí odkaz:
https://doaj.org/article/97a56772865248cc95c8c2981abdc580
Autor:
Dayle Sampson, Thomas D. Yager, Brian Fox, Laura Shallcross, Leo McHugh, Therese Seldon, Antony Rapisarda, Roslyn A. Hendriks, Richard B. Brandon, Krupa Navalkar, Nandi Simpson, Sian Stafford, Eliza Gil, Cristina Venturini, Evi Tsaliki, Jennifer Roe, Benjamin Chain, Mahdad Noursadeghi
Publikováno v:
BMC Medicine, Vol 18, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/d740ed64c3ac49a68c827986110142dc
Autor:
Catherine J, Reynolds, Corinna, Pade, Joseph M, Gibbons, Ashley D, Otter, Kai-Min, Lin, Diana, Muñoz Sandoval, Franziska P, Pieper, David K, Butler, Siyi, Liu, George, Joy, Nasim, Forooghi, Thomas A, Treibel, Charlotte, Manisty, James C, Moon, Amanda, Semper, Tim, Brooks, Áine, McKnight, Daniel M, Altmann, Rosemary J, Boyton, Hakam, Abbass, Aderonke, Abiodun, Mashael, Alfarih, Zoe, Alldis, Oliver E, Amin, Mervyn, Andiapen, Jessica, Artico, João B, Augusto, Georgina L, Baca, Sasha N L, Bailey, Anish N, Bhuva, Alex, Boulter, Ruth, Bowles, Olivia V, Bracken, Ben, O'Brien, Natalie, Bullock, Gabriella, Captur, Olivia, Carr, Nicola, Champion, Carmen, Chan, Aneesh, Chandran, Tom, Coleman, Jorge, Couto de Sousa, Xose, Couto-Parada, Eleanor, Cross, Teresa, Cutino-Moguel, Silvia, D'Arcangelo, Rhodri H, Davies, Brooke, Douglas, Cecilia, Di Genova, Keenan, Dieobi-Anene, Mariana O, Diniz, Anaya, Ellis, Karen, Feehan, Malcolm, Finlay, Marianna, Fontana, Sasha, Francis, David, Gillespie, Derek, Gilroy, Matt, Hamblin, Gabrielle, Harker, Georgia, Hemingway, Jacqueline, Hewson, Wendy, Heywood, Lauren M, Hickling, Bethany, Hicks, Aroon D, Hingorani, Lee, Howes, Ivie, Itua, Victor, Jardim, Wing-Yiu Jason, Lee, Melaniepetra, Jensen, Jessica, Jones, Meleri, Jones, Vikas, Kapil, Caoimhe, Kelly, Hibba, Kurdi, Jonathan, Lambourne, Aaron, Lloyd, Sarah, Louth, Mala K, Maini, Vineela, Mandadapu, Katia, Menacho, Celina, Mfuko, Kevin, Mills, Sebastian, Millward, Oliver, Mitchelmore, Christopher, Moon, James, Moon, Sam M, Murray, Mahdad, Noursadeghi, Ashley, Otter, Susana, Palma, Ruth, Parker, Kush, Patel, Mihaela, Pawarova, Steffen E, Petersen, Brian, Piniera, Lisa, Rannigan, Alicja, Rapala, Amy, Richards, Matthew, Robathan, Joshua, Rosenheim, Cathy, Rowe, Matthew, Royds, Jane, Sackville West, Genine, Sambile, Nathalie M, Schmidt, Hannah, Selman, Andreas, Seraphim, Mihaela, Simion, Angelique, Smit, Michelle, Sugimoto, Leo, Swadling, Stephen, Taylor, Nigel, Temperton, Stephen, Thomas, George D, Thornton, Art, Tucker, Ann, Varghese, Jessry, Veerapen, Mohit, Vijayakumar, Tim, Warner, Sophie, Welch, Hannah, White, Theresa, Wodehouse, Lucinda, Wynne, Dan, Zahedi, Benjamin, Chain
Publikováno v:
Science (New York, N.Y.). 377(6603)
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show p
Autor:
Dan, Frampton, Hagen, Schwenzer, Marino, Gabriele, Butcher, Lee M., Gabriele, Pollara, Janos, Kriston-Vizi, Cristina, Venturini, Rachel, Austin, Karina Ferreira de Castro, Robin, Ketteler, Benjamin, Chain, Richard, Goldstein, Weiss, Robin A., Stephan, Beck, Ariberto, Fassati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3978::b42b7c9c7123ea05e822bb52ac17c5dd
http://hdl.handle.net/11570/3120630
http://hdl.handle.net/11570/3120630
Autor:
Benjamin Chain1,2 b.chain@ucl.ac.uk, Bowen, Helen3, Hammond, John3, Posch, Wilfried1, Rasaiyaah, Jane1, Jhen Tsang1, Noursadeghi, Mahdad1
Publikováno v:
BMC Bioinformatics. 2010, Vol. 11, p344-358. 15p.