Efficient CAR T cell targeting of the CA125 extracellular repeat domain of MUC16

Autor: Gunnar Kvalheim, Kristina Lindemann, Ben Davidson, Line Bjorge, Else Marit Inderberg, Sébastien Wälchli, Emmet McCormack, Katrin Kleinmanns, David J Warren, Erik Rokkones, Martine Lode, Nicholas P Casey, Christopher Forcados, Pascal F Gelebart, Sandy Joaquina, Emmanuelle Benard, Fatemeh Kaveh, Benjamin Caulier, Christiane Helgestad Gjerde, Elvira García de Jalón, Marit Renee Myhre

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)

Background Ovarian cancer (OC) is the leading cause of death from gynecologic malignancies in the Western world. Contributing factors include a high frequency of late-stage diagnosis, the development of chemoresistance, and the evasion of host immune

Externí odkaz: https://doaj.org/article/162ad2ed429c4bd1b84eb0e5bfee44ad

Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia

Autor: Benjamin Caulier, Gaëlle Stofleth, Dalil Hannani, Mélanie Guidetti, Véronique Josserand, David Laurin, Jadwiga Chroboczek, Pascal Mossuz, Dominique Plantaz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 181-190 (2021)

Intensive systemic chemotherapy is the gold standard of acute myeloid leukemia (AML) treatment and is associated with considerable off-target toxicities. Safer and targeted delivery systems are thus urgently needed. In this study, we evaluated a viru

Externí odkaz: https://doaj.org/article/32dbb671c52b4ce79a03a5d7832faa1b

How CAR T Cells Breathe

Autor: Christopher Forcados, Sandy Joaquina, Nicholas Paul Casey, Benjamin Caulier, Sébastien Wälchli

Publikováno v: Cells, Vol 11, Iss 9, p 1454 (2022)

The manufacture of efficacious CAR T cells represents a major challenge in cellular therapy. An important aspect of their quality concerns energy production and consumption, known as metabolism. T cells tend to adopt diverse metabolic profiles depend

Externí odkaz: https://doaj.org/article/3e5115d1a4954d548fda248c30a65dce

Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia

Autor: Dominique Plantaz, Dalil Hannani, Jadwiga Chroboczek, Benjamin Caulier, Mélanie Guidetti, Gaëlle Stofleth, Véronique Josserand, David Laurin, Pascal Mossuz

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 181-190 (2021)
Molecular Therapy-Methods and Clinical Development
Molecular Therapy-Methods and Clinical Development, Nature Publishing Group, 2020, ⟨10.1016/j.omtm.2020.11.009⟩
Molecular Therapy. Methods & Clinical Development

Intensive systemic chemotherapy is the gold standard of acute myeloid leukemia (AML) treatment and is associated with considerable off-target toxicities. Safer and targeted delivery systems are thus urgently needed. In this study, we evaluated a viru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6efb508e07b9fd77da0853d5040ce25
https://doi.org/10.1016/j.omtm.2020.11.009

Recombinant Transcription Factors (TFs) Fused to ZEBRA Minimal Transduction Domain (MD) for Modulation of mRNA Transcripts

Autor: Jean-Luc Lenormand, Benjamin Caulier, David Laurin

Publikováno v: Methods in Molecular Biology ISBN: 9781071617519

Transcription factors (TFs) are key players in the control of gene expression and consequently all major cellular process, ranging from cell fate determination to cell cycle control and response to the environment.In particular cases, their ectopic e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab14292a9e8422d28196c176b20b9d4
https://doi.org/10.1007/978-1-0716-1752-6_19