Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Benjamin, Bourgeois"'
Autor:
Harald Hornegger, Aleksandra S. Anisimova, Adnan Muratovic, Benjamin Bourgeois, Elena Spinetti, Isabell Niedermoser, Roberto Covino, Tobias Madl, G. Elif Karagöz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-26 (2024)
Abstract The insulin-like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a conserved RNA-binding protein that regulates RNA stability, localization and translation. IGF2BP1 is part of various ribonucleoprotein (RNP) condensates. However, the mec
Externí odkaz:
https://doaj.org/article/36ec9943f4844727a70012fe37dd092c
Autor:
Emil Spreitzer, T. Reid Alderson, Benjamin Bourgeois, Loretta Eggenreich, Hermann Habacher, Greta Bramerdorfer, Iva Pritišanac, Pedro A. Sánchez-Murcia, Tobias Madl
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 118-133 (2022)
Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share distinct DNA binding domains, which allows to group them into protein families. Among them, the
Externí odkaz:
https://doaj.org/article/7f409bd87d6e4290a919dff475fc1900
Publikováno v:
Journal of Magnetic Resonance Open, Vol 12, Iss , Pp 100074- (2022)
Intrinsically disordered regions (IDRs) lack stable tertiary structure and instead rapidly interconvert between different conformations. This structural plasticity enables IDRs to act as key players in cellular signaling pathways. Transcription facto
Externí odkaz:
https://doaj.org/article/30914e4031ca4878afee130730318f0d
Autor:
Benjamin Bourgeois, Tianshu Gui, Diana Hoogeboom, Henry G. Hocking, Gesa Richter, Emil Spreitzer, Martin Viertler, Klaus Richter, Tobias Madl, Boudewijn M.T. Burgering
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109446- (2021)
Summary: Transcription factors harbor defined regulatory intrinsically disordered regions (IDRs), which raises the question of how they mediate binding to structured co-regulators and modulate their activity. Here, we present a detailed molecular reg
Externí odkaz:
https://doaj.org/article/4457a9afbd544c7d92f50c585c7e1e84
Autor:
Aneta J. Lenard, Qishun Zhou, Corina Madreiter-Sokolowski, Benjamin Bourgeois, Hermann Habacher, Yukti Khanna, Tobias Madl
Publikováno v:
Cells, Vol 11, Iss 4, p 592 (2022)
Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported. The hallmark of these diseases is the formation of pathological aggregates and fibrils in neural cells. Many studies
Externí odkaz:
https://doaj.org/article/fdf41f33d1244d3e9b997117ee0efbeb
Autor:
Fangrong Zhang, Gesa Richter, Benjamin Bourgeois, Emil Spreitzer, Armin Moser, Andreas Keilbach, Petra Kotnik, Tobias Madl
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 69 (2021)
A fundamental step in developing a protein drug is the selection of a stable storage formulation that ensures efficacy of the drug and inhibits physiochemical degradation or aggregation. Here, we designed and evaluated a general workflow for screenin
Externí odkaz:
https://doaj.org/article/9239d8562f6f49609c110c7629a31816
Autor:
Peter M. Abuja, Daniela Pabst, Benjamin Bourgeois, Martina Loibner, Christine Ulz, Iris Kufferath, Ulrike Fackelmann, Cornelia Stumptner, Rainer Kraemer, Tobias Madl, Kurt Zatloukal
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8010
Molecular diagnostics in healthcare relies increasingly on genomic and transcriptomic methodologies and requires appropriate tissue specimens from which nucleic acids (NA) of sufficiently high quality can be obtained. Besides the duration of ischemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbcfa05aaec013d7a070eff5d32af67
Autor:
Johannes Pilic, Benjamin Gottschalk, Benjamin Bourgeois, Zhanat Koshenov, Furkan E. Oflaz, Yusuf C. Erdogan, Varda Shoshan-Barmatz, Tobias Madl, Wolfgang F. Graier, Roland Malli
SummaryDespite progress in understanding cellular energy stress responses, the role of metabolic enzymes in these processes remains understudied. Here, we discovered that hexokinase 1 (HK1), a key glycolytic enzyme, clusters into ring-like structures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd86bc235e420f466b55cb222241dad
https://doi.org/10.1101/2023.03.20.533440
https://doi.org/10.1101/2023.03.20.533440
Autor:
Chintan N. Koyani, Christopher Trummer, Niroj Shrestha, Susanne Scheruebel, Benjamin Bourgeois, Ioanna Plastira, Sandra Kickmaier, Harald Sourij, Peter P. Rainer, Tobias Madl, Wolfgang Sattler, Brigitte Pelzmann, Ernst Malle, Dirk von Lewinski
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Some oral anti-hyperglycemic drugs, including gliptins that inhibit dipeptidyl peptidase 4 (DPP4), have been linked to the increased risk of heart failure (HF) in type-2 diabetic patients. While the cardiovascular safety trial, TECOS, revealed no lin
Externí odkaz:
https://doaj.org/article/5c059d136840483897cf25c2ae10e440
Autor:
Peter M. Abuja, Daniela Pabst, Benjamin Bourgeois, Martina Loibner, Christine Ulz, Iris Kufferath, Ulrike Fackelmann, Conny Stumptner, Rainer Kraemer, Tobias Madl, Kurt Zatloukal
Molecular diagnostics in healthcare relies increasingly on genomic and transcriptomic method-ologies and requires appropriate tissue specimens from which nucleic acids (NA) of sufficiently high quality can be obtained. Besides suration of ischemia an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31aad129b55ce5b0b50c832b6b35cf2f
https://doi.org/10.20944/preprints202212.0457.v1
https://doi.org/10.20944/preprints202212.0457.v1