Zobrazeno 1 - 10
of 86 568
pro vyhledávání: '"Benjamin, B."'
The structure and function of a protein are determined by its amino acid sequence. While random mutations change a protein's sequence, evolutionary forces shape its structural fold and biological activity. Studies have shown that neutral networks can
Externí odkaz:
http://arxiv.org/abs/2411.09054
This work is motivated by the following problem: Can we identify the disease-causing gene in a patient affected by a monogenic disorder? This problem is an instance of root cause discovery. In particular, we aim to identify the intervened variable in
Externí odkaz:
http://arxiv.org/abs/2410.12151
Autor:
Lane, Benjamin B., Chen, Junxin, Pagano, Ronald E., Aronson, Scott, Cole, Garrett D., Yin, Xinghui, Corbitt, Thomas R., Mavalvala, Nergis
Squeezed mechanical states are a valuable tool for quantum sensing and error correction in quantum computing, and a pivotal platform for tests of fundamental physics. Recently, solid state mechanical oscillators have been prepared in squeezed states
Externí odkaz:
http://arxiv.org/abs/2410.09208
Autor:
Momi, Asheesh S., Abbott, Michael C., Rubinfien, Julian, Machta, Benjamin B., Graf, Isabella R.
Sound produces surface waves along the cochlea's basilar membrane. To achieve the ear's astonishing frequency resolution and sensitivity to faint sounds, dissipation in the cochlea must be canceled via active processes in hair cells, effectively brin
Externí odkaz:
http://arxiv.org/abs/2407.14496
Protein language models trained on the masked language modeling objective learn to predict the identity of hidden amino acid residues within a sequence using the remaining observable sequence as context. They do so by embedding the residues into a hi
Externí odkaz:
http://arxiv.org/abs/2407.07265
Autor:
Mattingly, Henry H., Kamino, Keita, Ong, Jude, Kottou, Rafaela, Emonet, Thierry, Machta, Benjamin B.
Organisms must perform sensory-motor behaviors to survive. What bounds or constraints limit behavioral performance? Previously, we found that the gradient-climbing speed of a chemotaxing Escherichia coli is near a bound set by the limited information
Externí odkaz:
http://arxiv.org/abs/2407.07264
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition associated with difficulties with social interactions, communication, and restricted or repetitive behaviors. To characterize ASD, investigators often use functional connectivity derive
Externí odkaz:
http://arxiv.org/abs/2406.13111
E. coli use a regular lattice of receptors and attached kinases to detect and amplify faint chemical signals. Kinase output is characterized by precise adaptation to a wide range of background ligand levels and large gain in response to small relativ
Externí odkaz:
http://arxiv.org/abs/2405.18331
Autor:
Rouches, Mason N., Machta, Benjamin B.
The three-dimensional organization of chromatin is thought to play an important role in controlling gene expression. Specificity in expression is achieved through the interaction of transcription factors and other nuclear proteins with particular seq
Externí odkaz:
http://arxiv.org/abs/2404.19158
Autor:
Chen, Zhaomeng, He, Zihuai, Chu, Benjamin B., Gu, Jiaqi, Morrison, Tim, Sabatti, Chiara, Candès, Emmanuel
Identifying which variables do influence a response while controlling false positives pervades statistics and data science. In this paper, we consider a scenario in which we only have access to summary statistics, such as the values of marginal empir
Externí odkaz:
http://arxiv.org/abs/2402.12724