Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells

Autor: James D.P. Rhodes, Angelika Feldmann, Benjamín Hernández-Rodríguez, Noelia Díaz, Jill M. Brown, Nadezda A. Fursova, Neil P. Blackledge, Praveen Prathapan, Paula Dobrinic, Miles K. Huseyin, Aleksander Szczurek, Kai Kruse, Kim A. Nasmyth, Veronica J. Buckle, Juan M. Vaquerizas, Robert J. Klose

Publikováno v: Cell Reports, Vol 30, Iss 3, Pp 820-835.e10 (2020)

Summary: How chromosome organization is related to genome function remains poorly understood. Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.

Externí odkaz: https://doaj.org/article/04343456c33648c2bdd2312d131af175

One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2

Autor: Farina Windener, Odile Boespflug-Tanguy, Qiao Ling Cui, Sabah Mozafari, Benjamín Hernández-Rodríguez, Anne Baron-Van Evercooren, Christian Thomas, Tanja Kuhlmann, Hans R. Schöler, Jürgen Winkler, Yu Kang T. Xu, Martin Stehling, Linda Ottoboni, Gianvito Martino, Marc Ehrlich, Stefanie Albrecht, Konstantina Chanoumidou, Sergiy Velychko, Juan M. Vaquerizas, Jack P. Antel, Kee-Pyo Kim

Publikováno v: Stem Cell Reports
Stem Cell Reports, Elsevier, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩
Stem Cell Reports, 2021, ⟨10.1016/j.stemcr.2021.03.001⟩

Summary Limited access to human oligodendrocytes impairs better understanding of oligodendrocyte pathology in myelin diseases. Here, we describe a method to robustly convert human fibroblasts directly into oligodendrocyte-like cells (dc-hiOLs), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf0d0735734348b24673ac23d4c684
https://doi.org/10.1016/j.stemcr.2021.03.001

Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements

Autor: Damir Baranasic, Matthias Hörtenhuber, Piotr J. Balwierz, Tobias Zehnder, Abdul Kadir Mukarram, Chirag Nepal, Csilla Várnai, Yavor Hadzhiev, Ada Jimenez-Gonzalez, Nan Li, Joseph Wragg, Fabio M. D’Orazio, Dorde Relic, Mikhail Pachkov, Noelia Díaz, Benjamín Hernández-Rodríguez, Zelin Chen, Marcus Stoiber, Michaël Dong, Irene Stevens, Samuel E. Ross, Anne Eagle, Ryan Martin, Oluwapelumi Obasaju, Sepand Rastegar, Alison C. McGarvey, Wolfgang Kopp, Emily Chambers, Dennis Wang, Hyejeong R. Kim, Rafael D. Acemel, Silvia Naranjo, Maciej Łapiński, Vanessa Chong, Sinnakaruppan Mathavan, Bernard Peers, Tatjana Sauka-Spengler, Martin Vingron, Piero Carninci, Uwe Ohler, Scott Allen Lacadie, Shawn M. Burgess, Cecilia Winata, Freek van Eeden, Juan M. Vaquerizas, José Luis Gómez-Skarmeta, Daria Onichtchouk, Ben James Brown, Ozren Bogdanovic, Erik van Nimwegen, Monte Westerfield, Fiona C. Wardle, Carsten O. Daub, Boris Lenhard, Ferenc Müller

Publikováno v: Baranasic, D, Hörtenhuber, M, Balwierz, P J, Zehnder, T, Mukarram, A K, Nepal, C, Várnai, C, Hadzhiev, Y, Jimenez-Gonzalez, A, Li, N, Wragg, J, D’Orazio, F M, Relic, D, Pachkov, M, Díaz, N, Hernández-Rodríguez, B, Chen, Z, Stoiber, M, Dong, M, Stevens, I, Ross, S E, Eagle, A, Martin, R, Obasaju, O, Rastegar, S, McGarvey, A C, Kopp, W, Chambers, E, Wang, D, Kim, H R, Acemel, R D, Naranjo, S, Łapiński, M, Chong, V, Mathavan, S, Peers, B, Sauka-Spengler, T, Vingron, M, Carninci, P, Ohler, U, Lacadie, S A, Burgess, S M, Winata, C, van Eeden, F, Vaquerizas, J M, Gómez-Skarmeta, J L, Onichtchouk, D, Brown, B J, Bogdanovic, O, van Nimwegen, E, Westerfield, M, Wardle, F C, Daub, C O, Lenhard, B & Müller, F 2022, ' Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements ', Nature Genetics, vol. 54, no. 7, pp. 1037-1050 . https://doi.org/10.1038/s41588-022-01089-w
Nature Genetics, 54, 1037–1050
Digital.CSIC. Repositorio Institucional del CSIC
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14 pages, 8 figures, supplementary information https://doi.org/10.1038/s41588-022-01089-w.-- Data availability: Raw and aligned sequencing data are available at https://danio-code.zfin.org/dataExport/. The raw sequencing data produced for this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c9b0ff730aa047c825365d177a9878
https://edoc.unibas.ch/89500/

Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein.

Autor: Brenda López-Falcón, Silvia Meyer-Nava, Benjamín Hernández-Rodríguez, Adam Campos, Daniel Montero, Enrique Rudiño, Martha Vázquez, Mario Zurita, Viviana Valadez-Graham

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113182 (2014)

The human ATRX gene encodes hATRX, a chromatin-remodeling protein harboring an helicase/ATPase and ADD domains. The ADD domain has two zinc fingers that bind to histone tails and mediate hATRX binding to chromatin. dAtrx, the putative ATRX homolog in

Externí odkaz: https://doaj.org/article/41a41d8806b548bf805498ba4a5657f1

Cohesin disrupts polycomb-dependent chromosome interactions

Autor: Paula Dobrinić, Kai Kruse, Nadezda A. Fursova, Angelika Feldmann, Juan M. Vaquerizas, Praveen Prathapan, Benjamín Hernández-Rodríguez, Robert J. Klose, Neil P. Blackledge, Miles K. Huseyin, Veronica J. Buckle, K. A. Nasmyth, Jill M. Brown, Noelia Díaz, James D.P. Rhodes, Aleksander T. Szczurek

Publikováno v: BioRxiv

How chromosome organisation is related to genome function remains poorly understood. Cohesin, loop-extrusion, and CTCF have been proposed to create structures called topologically associating domains (TADs) to regulate gene expression. Here, we exami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cddb4e32d73a8cefcd5633745028d87