Zobrazeno 1 - 10
of 1 469
pro vyhledávání: '"Benita S"'
Autor:
Cassie Liu, Makenzie Vorderbruggen, Catalina Muñoz-Trujillo, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Adam R. Karpf
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-22 (2024)
Abstract Background Genetic studies implicate the oncogenic transcription factor Forkhead Box M1 (FOXM1) as a potential therapeutic target in high-grade serous ovarian cancer (HGSOC). We evaluated the activity of different FOXM1 inhibitors in HGSOC c
Externí odkaz:
https://doaj.org/article/38ff363565fe49e8b67ed19a2b86110f
Autor:
Anastasia Sacharidou, Ken Chambliss, Jun Peng, Jose Barrera, Keiji Tanigaki, Katherine Luby-Phelps, İpek Özdemir, Sohaib Khan, Shashank R. Sirsi, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Mohammed Kanchwala, Adwait A. Sathe, Andrew Lemoff, Chao Xing, Kenneth Hoyt, Chieko Mineo, Philip W. Shaul
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The estrogen receptor (ER) designated ERα has actions in many cell and tissue types that impact glucose homeostasis. It is unknown if these include mechanisms in endothelial cells, which have the potential to influence relative obesity, and
Externí odkaz:
https://doaj.org/article/a6ad2b7de7ba40389fc7ade98aaa8270
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract FOXM1 (Forkhead box M1) is an oncogenic transcription factor that is greatly upregulated in breast cancer and many other cancers where it promotes tumorigenesis, and cancer growth and progression. It is expressed in all subtypes of breast ca
Externí odkaz:
https://doaj.org/article/1ca00effc74743619a82dfd0a0897736
Autor:
Glennis Fiona J. Javelosa-Tan, Benita S. Padilla, Concesa B. Cabanayan-Casasola, Irina M. Rey-Roxas, Carlo Irwin A. Panelo
Publikováno v:
Saudi Journal of Kidney Diseases and Transplantation, Vol 34, Iss 5, Pp 389-396 (2023)
The cost of kidney transplantation (KT) and its follow-up care greatly exceeds the mean annual family income. Governmental support during the post-transplant period is needed. This study aimed to identify the drivers of cost during the 1st year after
Externí odkaz:
https://doaj.org/article/48f63888ffa046e4b0c2b38e51f79770
Autor:
Ipshita Nandi, Harvey W. Smith, Virginie Sanguin-Gendreau, Linjia Ji, Alain Pacis, Vasilios Papavasiliou, Dongmei Zuo, Stella Nam, Sherif S. Attalla, Sung Hoon Kim, Sierra Lusson, Hellen Kuasne, Anne-Marie Fortier, Paul Savage, Constanza Martinez Ramirez, Morag Park, John A. Katzenellenbogen, Benita S. Katzenellenbogen, William J. Muller
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
Activation of the tyrosine kinase c-Src promotes breast cancer progression and poor outcomes, yet the underlying mechanisms are incompletely understood. Here, we have shown that deletion of c-Src in a genetically engineered model mimicking the lumina
Externí odkaz:
https://doaj.org/article/6febccb2e0664106aef4e61bab5617dd
Autor:
Qianying Zuo, Karen L. Chen, Alicia Arredondo Eve, Yu-Jeh Liu, Sung Hoon Kim, Benita S. Katzenellenbogen, John A. Katzenellenbogen, Zeynep Madak-Erdogan
Publikováno v:
Nutrients, Vol 13, Iss 10, p 3334 (2021)
About 20–30% of premenopausal women have metabolic syndrome, and the number is almost double in postmenopausal women, and these women have an increased risk of hepatosteatosis. Postmenopausal women with metabolic syndrome are often treated with hor
Externí odkaz:
https://doaj.org/article/09e3a940dfab4019919dcfc301eb8b29
Autor:
Emmanuel Guivarc'h, Mélissa Buscato, Anne‐Laure Guihot, Julie Favre, Emilie Vessières, Linda Grimaud, Jamal Wakim, Nada‐Joe Melhem, Rana Zahreddine, Marine Adlanmerini, Laurent Loufrani, Claude Knauf, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Jean‐Michel Foidart, Pierre Gourdy, Françoise Lenfant, Jean‐François Arnal, Daniel Henrion, Coralie Fontaine
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 13 (2018)
Background Although estrogen receptor α (ERα) acts primarily as a transcription factor, it can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic mouse models previously highlighted the key role of ERα membran
Externí odkaz:
https://doaj.org/article/ea165dec76a24ebaaa7a43cfe4b539b6
Autor:
Zeynep Madak‐Erdogan, Tze‐Howe Charn, Yan Jiang, Edison T Liu, John A Katzenellenbogen, Benita S Katzenellenbogen
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp n/a-n/a (2017)
Externí odkaz:
https://doaj.org/article/509dfa82225f4dbd8fe642cd5e6c7edb
Autor:
Anne Abot, Coralie Fontaine, Mélissa Buscato, Romain Solinhac, Gilles Flouriot, Aurélie Fabre, Anne Drougard, Shyamala Rajan, Muriel Laine, Alain Milon, Isabelle Muller, Daniel Henrion, Marine Adlanmerini, Marie‐Cécile Valéra, Anne Gompel, Céline Gerard, Christel Péqueux, Mélanie Mestdagt, Isabelle Raymond‐Letron, Claude Knauf, François Ferriere, Philippe Valet, Pierre Gourdy, Benita S Katzenellenbogen, John A Katzenellenbogen, Françoise Lenfant, Geoffrey L Greene, Jean‐Michel Foidart, Jean‐François Arnal
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1328-1346 (2014)
Abstract Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are
Externí odkaz:
https://doaj.org/article/f81d485b302d454596333e69beb5f6bc
Autor:
Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin, Scott J Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S Katzenellenbogen, Emad Tajkhorshid, Patrick R Griffin, Yang Shen, Sarat Chandarlapaty, John A Katzenellenbogen, Geoffrey L Greene
Publikováno v:
eLife, Vol 5 (2016)
Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies. Cell-based studies demonstrated that these mutants confer ERα constitutive activity and
Externí odkaz:
https://doaj.org/article/d72eb07c0ab74842a4752908808171ae