Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Benita L. McVicker"'
Publikováno v:
Biology, Vol 12, Iss 10, p 1287 (2023)
Peroxisome-proliferator-activated receptor gamma (PPARγ) is a transcription factor with adipogenic, insulin-sensitizing, and antifibrotic properties. Strong PPARγ activators, such as the thiazolidinediones, can induce unwanted effects such as edema
Externí odkaz:
https://doaj.org/article/159a9c7184624b99aec01ba011d624c4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12331 (2023)
The phosphatidylinositol (PI3K)/AKT/mTOR axis represents an important therapeutic target to treat human cancers. A well-described downstream target of the PI3K pathway is the forkhead box O (FOXO) transcription factor family. FOXOs have been implicat
Externí odkaz:
https://doaj.org/article/2f47a36230ea468eaf1f0675cfe66e7f
Autor:
Chuhan Zhang, Yu Hang, Weimin Tang, Diptesh Sil, Heather C. Jensen-Smith, Robert G. Bennett, Benita L. McVicker, David Oupický
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 669 (2022)
Alcohol-associated liver disease (AALD) is a major cause of liver disorders worldwide. Current treatment options are limited, especially for AALD-associated fibrosis. Promising approaches include RNA interference for miR-155 overexpression in Kupffer
Externí odkaz:
https://doaj.org/article/372bcf1685d943d29308743cd40e5f69
Autor:
Karuna Rasineni, Serene M. L. Lee, Benita L. McVicker, Natalia A. Osna, Carol A. Casey, Kusum K. Kharbanda
Publikováno v:
Biology, Vol 10, Iss 1, p 19 (2020)
Background: Work from our laboratory has shown that the ethanol-induced increase in apoptotic hepatocellular death is closely related to the impairment in the ability of the asialoglycoprotein receptor (ASGP-R) to remove neighboring apoptotic cells.
Externí odkaz:
https://doaj.org/article/3e43edfc08e8494c96a635b9f0fa098f
Publikováno v:
Biology, Vol 9, Iss 7, p 151 (2020)
Hepatic fibrosis is the accumulation of excess collagen as a result of chronic liver injury. If left unabated, hepatic fibrosis can lead to the disruption of the liver architecture, portal hypertension, and increased risk of progression to cirrhosis
Externí odkaz:
https://doaj.org/article/d183649c25ca442e993e97cc658ea80a
Autor:
Benita L. McVicker, Robert G. Bennett
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosi
Externí odkaz:
https://doaj.org/article/3bfa2c63423c4b02ad8ff33cf3630e82
Autor:
Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey
Publikováno v:
International Journal of Hepatology, Vol 2012 (2012)
Introduction. Mitochondrial damage and disruption in oxidative phosphorylation contributes to the pathogenesis of alcoholic liver injury. Herein, we tested the hypothesis that the hepatoprotective actions of betaine against alcoholic liver injury occ
Externí odkaz:
https://doaj.org/article/6743cadb2f644066b57fbf4fe06b511a
Publikováno v:
International Journal of Hepatology, Vol 2012 (2012)
Steatosis, an early manifestation in alcoholic liver disease, is associated with the accumulation of hepatocellular lipid droplets (LDs). However, the role ethanol metabolism has in LD formation and turnover remains undefined. Here, we assessed LD dy
Externí odkaz:
https://doaj.org/article/8680688a6f5945b087a9002254b0d268
Publikováno v:
Hepatology Communications. 7
Publikováno v:
World Journal of Gastroenterology
The aberrant use of alcohol is a major factor in cancer progression and metastasis. Contributing mechanisms include the systemic effects of alcohol and the exchange of bioactive molecules between cancerous and non-cancerous cells along the brain-gut-