Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Benika J. Pinch"'
Autor:
Kun Ping Lu, Hyuk-Soo Seo, Yujin Chun, Christopher M. Browne, Theresa D. Manz, Xiao Zhen Zhou, Zainab M. Doctor, Xiaolan Lian, Zoe C. Yeoh, Shin Kibe, Scott B. Ficarro, Nir London, Benika J. Pinch, Nicholas E. Vangos, Behnam Nabet, Stephen Buratowski, Dina Daitchman, Shingo Kozono, Daniel Zaidman, Nathanael S. Gray, Jarrod A. Marto, Mikaela L. Mohardt, Li Tan, Sirano Dhe-Paganon, Ezekiel A. Geffken
Publikováno v:
Nature chemical biology
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) is commonly overexpressed in human cancers, including pancreatic ductal adenocarcinoma (PDAC). While Pin1 is dispensable for viability in mice, it is required for activated Ras to induce t
Autor:
Laura Tandeske, Claudio R. Thoma, Elizabeth R. Sprague, Scott M. Brittain, Lynn M. McGregor, Edward P. Harvey, Pier Luca D’Alessandro, Markus Schirle, Dustin Dovala, Dennis L. Buckley, Zachary J. Hauseman, Scott Gleim, Benika J. Pinch, William C. Forrester
Targeted protein degradation is a rapidly developing therapeutic modality that promises lower dosing and enhanced selectivity as compared to traditional occupancy-driven inhibitors, and the potential to modulate historically intractable targets. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::228bf26e4d8c7058504d63e85228d26a
https://doi.org/10.1101/2020.08.13.249482
https://doi.org/10.1101/2020.08.13.249482
Autor:
Evon Poon, Anli Yang, Xiao Zhou, Efrat Resnick, Daniel Zaidman, Roni Oren, Yann Jamin, Shingo Kozono, Colin J. Daniel, Ellen M. Langer, Shijie He, Behnam Nabet, Yu-Hong Chen, Christopher M. Browne, Hyuk-Soo Seo, Louis Chesler, Kun Ping Lu, Benika J. Pinch, Rosalie C. Sears, Shin Kibe, Liat Stoler-Barak, Ziv Shulman, Nir London, Samuel Sidi, Christian Dubiella, Thomas Look, Nicholas E. Vangos, Kazuhiro Koikawa, Xiaolan Lian, Chunhui Wang, Nathaniel Gray, Trevor Manz, Jarrod A. Marto, Richa B. Shah, Ezekiel A. Geffken, Sirano Dhe-Paganon, Scott B. Ficarro
The peptidyl-prolyl cis-trans isomerase, Pin1, acts as a unified signaling hub that is exploited in cancer to activate oncogenes and inactivate tumor suppressors, in particular through up-regulation of c-Myc target genes. However, despite considerabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3ceb5d0f3a7e590d161df59af1ffd9
https://doi.org/10.1101/2020.03.20.998443
https://doi.org/10.1101/2020.03.20.998443
Autor:
Sirano Dhe-Paganon, Benika J. Pinch, Mark W. Zimmerman, Richa B. Shah, Kun Ping Lu, Jarrod A. Marto, Shuning He, Eriko Koide, Daniel Zaidman, Christopher M. Browne, Ziv Shulman, Barbara Martins da Costa, Christian Dubiella, Evon Poon, Guillaume Adelmant, Nir London, Xiao Zhen Zhou, Chu Wang, Ellen M. Langer, Kazuhiro Koikawa, Theresa D. Manz, Thomas Look, Xiaolan Lian, Hyuk-Soo Seo, Annan Yang, Louis Chesler, Ezekiel A. Geffken, Liat Stoler-Barak, Shin Kibe, Efrat Resnick, Nicholas E. Vangos, Shabnam Sharifzadeh, Shingo Kozono, Colin J. Daniel, Scott B. Ficarro, Roni Oren, Ying Chen, Nathanael S. Gray, Rosalie C. Sears, Samuel Sidi, Adi Rogel, Zainab M. Doctor, Behnam Nabet, Yann Jamin
Publikováno v:
Nat Chem Biol
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library t
Autor:
Dustin Dovala, Markus Schirle, Elizabeth R. Sprague, Zachary J. Hauseman, Lei Xu, Scott Gleim, Dennis L. Buckley, Laura Tandeske, William C. Forrester, Scott M. Brittain, Pier Luca D’Alessandro, Benika J. Pinch, Lynn M. McGregor, Edward P. Harvey, Claudio R. Thoma, Jennifer Lipps
Publikováno v:
Cell Chemical Biology. 29:57-66.e6
Targeted protein degradation is a rapidly developing therapeutic modality that promises lower dosing and enhanced selectivity as compared to traditional occupancy-driven inhibitors, and the potential to modulate historically intractable targets. Whil
Autor:
Megan K. Herbert, Zainab M. Doctor, Hyuk-Soo Seo, Sirano Dhe-Paganon, Kun Ping Lu, Li Tan, Xiao Zhen Zhou, Chenxi Qiu, Brian P. Jackson, Yuanzhong Chen, Yu-Min Lin, Walter Massefski, Chun-Hau Chen, Shingo Kozono, Ziang Jeff Gao, Benika J. Pinch, Xiaolan Lian
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination safely cures fatal acute promyelocytic leukemia, but their mechanisms of action and efficacy are not fully understood. ATRA inhibits leukemia, breast, and liver cancer by targeting
Autor:
Sandro Santagata, Nathanael S. Gray, Theresa D. Manz, Nami Kim, Nobufumi Sekino, Xiao Zhen Zhou, Futoshi Suizu, Giorgio Gaglia, Dipikaa Akshinthala, Shizhong Ke, Benika J. Pinch, Manuel Hidalgo, Babara Wegiel, Kun Ping Lu, Senthil K. Muthuswamy, Yutaka Nezu, Kenoki Ohuchida, Shin Kibe, Gerburg M. Wulf, Chenxi Qiu, Nir London, Tae Ho Lee, Yoshinao Oda, Ana Verma, Kazuhiro Koikawa, John G. Clohessy, Masafumi Nakamura
Publikováno v:
Cell. 184:4753-4771.e27
Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and immunosuppressive tumor microenvironment (TME). Unique proline isomerase Pin1
Autor:
Nathanael S. Gray, Benika J. Pinch, Zhengnian Li, Caitlin E. Mills, Calla M. Olson, Radosław P. Nowak, Nicholas A. Eleuteri, Katherine A. Donovan, Mirra Chung, David A. Scott, Eric S. Fischer, Zainab M. Doctor, Peter K. Sorger
Publikováno v:
Cell Chem Biol
The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic
Autor:
Tao Meng, Benika J. Pinch, Kellie A. Woll, Brian P. Weiser, Wei Dong Gao, Roderic G. Eckenhoff, Andrew R. McKinstry-Wu, Qiansheng Liang, William P. Dailey, Manuel Covarrubias
Publikováno v:
ACS Chemical Neuroscience. 6:927-935
Propofol is a widely used intravenous general anesthetic. We synthesized 2-fluoro-1,3-diisopropylbenzene, a compound that we call “fropofol”, to directly assess the significance of the propofol 1-hydroxyl for pharmacologically relevant molecular
Autor:
Jarrod A. Marto, Dina Daitchman, Shingo Kozono, Christopher M. Browne, Daniel Zaidman, Stephen Buratowski, Kun Ping Lu, Hyuk-Soo Seo, Benika J. Pinch, Behnam Nabet, Lu Gong, Nathanael S. Gray, Xiao Zhou, Li Tan, Zainab M. Doctor, Sirano Dhe-Paganon, Nir London, Yujin Chun, Theresa D. Manz, Xiaolan Lian
Publikováno v:
Cancer Research. 79:2757-2757
Proline-directed phosphorylation at serine or threonine residues (pSer/Thr-Pro) regulates numerous cellular processes, including the cell cycle, transcription, and differentiation. Deregulation of such signaling networks is a hallmark of transformati