Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Beni Wolf"'
Autor:
Alexandra K. Gardino, Erica K. Evans, Joseph L. Kim, Natasja Brooijmans, Brian L. Hodous, Beni Wolf, Christoph Lengauer
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Cancer genomics and mechanistic studies have revealed that heterogeneous mutations within a single kinase can result in a variety of activation mechanisms. The challenge has been to match these insights with tailored drug discovery strategies to yiel
Externí odkaz:
https://doaj.org/article/ecaaeee92c114955a1ed8fac2d8ea24c
Autor:
Lecia V. Sequist, Aaron N. Hata, Beni Wolf, Sai-Hong I. Ou, Corinne Clifford, Erica K. Evans, Alice T. Shaw, Rebecca S. Heist, A. John Iafrate, Mari Mino-Kenudson, Dora Dias-Santagata, Richard B. Lanman, Rebecca J. Nagy, Jessica J. Lin, Varuna Nangia, Amanda K. Riley, Satoshi Yoda, Wenjia Su, Subba R. Digumarthy, Mandeep K. Banwait, Nicolas Marcoux, Viola W. Zhu, Inga T. Lennes, Justin F. Gainor, Jochen K. Lennerz, Hideko Isozaki, Zofia Piotrowska
Supplementary Data and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc96358440634edc76f9afcf0d045e29
https://doi.org/10.1158/2159-8290.22534325.v1
https://doi.org/10.1158/2159-8290.22534325.v1
Autor:
Lecia V. Sequist, Aaron N. Hata, Beni Wolf, Sai-Hong I. Ou, Corinne Clifford, Erica K. Evans, Alice T. Shaw, Rebecca S. Heist, A. John Iafrate, Mari Mino-Kenudson, Dora Dias-Santagata, Richard B. Lanman, Rebecca J. Nagy, Jessica J. Lin, Varuna Nangia, Amanda K. Riley, Satoshi Yoda, Wenjia Su, Subba R. Digumarthy, Mandeep K. Banwait, Nicolas Marcoux, Viola W. Zhu, Inga T. Lennes, Justin F. Gainor, Jochen K. Lennerz, Hideko Isozaki, Zofia Piotrowska
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e051601bd88ba6af4840dc715298fa
https://doi.org/10.1158/2159-8290.22534322.v1
https://doi.org/10.1158/2159-8290.22534322.v1
Autor:
Lipika Goyal, Mitesh Borad, Vivek Subbiah, Amit Mahipal, Suneel Kamath, Kabir Mody, Robin Katie Kelley, Richard Kim, Vaibhav Sahai, Anthony El-Khoueiry, Efrat Dotan, Oleg Schmidt-Kittler, Jinshan Shen, Kai Yu Jen, Alicia Deary, Wei Guo, Mahesh Padval, Cori Ann J. Sherwin, Charles Ferte, Beni Wolf, Alison M. Schram
Publikováno v:
Molecular Cancer Therapeutics. 20:P02-02
INTRODUCTION: Oncogenic FGFR2 alterations (fusions/rearrangements, amplifications, mutations) are key drivers in cholangiocarcinoma (CCA) and multiple solid tumors. Current pan-FGFR inhibitor (FGFRi) therapy is limited by off-isoform toxicity and acq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640967463759a01937bcf1d357f5ef4d
https://doi.org/10.1158/1535-7163.targ-21-p02-02
https://doi.org/10.1158/1535-7163.targ-21-p02-02
Autor:
Zofia, Piotrowska, Hideko, Isozaki, Jochen K, Lennerz, Justin F, Gainor, Inga T, Lennes, Viola W, Zhu, Nicolas, Marcoux, Mandeep K, Banwait, Subba R, Digumarthy, Wenjia, Su, Satoshi, Yoda, Amanda K, Riley, Varuna, Nangia, Jessica J, Lin, Rebecca J, Nagy, Richard B, Lanman, Dora, Dias-Santagata, Mari, Mino-Kenudson, A John, Iafrate, Rebecca S, Heist, Alice T, Shaw, Erica K, Evans, Corinne, Clifford, Sai-Hong I, Ou, Beni, Wolf, Aaron N, Hata, Lecia V, Sequist
Publikováno v:
Cancer discovery. 8(12)
We present a cohort of 41 patients with osimertinib resistance biopsies, including two with an acquired CCDC6-RET fusion. While RET fusions have been identified in resistant EGFR-mutant NSCLC, their role in acquired resistance to EGFR inhibitors is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb8ffec86e178defdc6fa4fed54803f3
https://pubmed.ncbi.nlm.nih.gov/30257958
https://pubmed.ncbi.nlm.nih.gov/30257958
Autor:
Vivek, Subbiah, Justin F, Gainor, Rami, Rahal, Jason D, Brubaker, Joseph L, Kim, Michelle, Maynard, Wei, Hu, Qiongfang, Cao, Michael P, Sheets, Douglas, Wilson, Kevin J, Wilson, Lucian, DiPietro, Paul, Fleming, Michael, Palmer, Mimi I, Hu, Lori, Wirth, Marcia S, Brose, Sai-Hong Ignatius, Ou, Matthew, Taylor, Elena, Garralda, Stephen, Miller, Beni, Wolf, Christoph, Lengauer, Timothy, Guzi, Erica K, Evans
Publikováno v:
Cancer discovery. 8(7)
The receptor tyrosine kinase rearranged during transfection (RET) is an oncogenic driver activated in multiple cancers, including non-small cell lung cancer (NSCLC), medullary thyroid cancer (MTC), and papillary thyroid cancer. No approved therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eec07db5df6b7d30c144f60995259458
https://pubmed.ncbi.nlm.nih.gov/29967074
https://pubmed.ncbi.nlm.nih.gov/29967074
Autor:
Erica K, Evans, Alexandra K, Gardino, Joseph L, Kim, Brian L, Hodous, Adam, Shutes, Alison, Davis, Xing Julia, Zhu, Oleg, Schmidt-Kittler, Doug, Wilson, Kevin, Wilson, Lucian, DiPietro, Yulian, Zhang, Natasja, Brooijmans, Timothy P, LaBranche, Agnieszka, Wozniak, Yemarshet K, Gebreyohannes, Patrick, Schöffski, Michael C, Heinrich, Daniel J, DeAngelo, Stephen, Miller, Beni, Wolf, Nancy, Kohl, Timothy, Guzi, Nicholas, Lydon, Andy, Boral, Christoph, Lengauer
Publikováno v:
Science translational medicine. 9(414)
Targeting oncogenic kinase drivers with small-molecule inhibitors can have marked therapeutic benefit, especially when administered to an appropriate genomically defined patient population. Cancer genomics and mechanistic studies have revealed that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44c23e872b4ee8effe4e9b9a2cdce3de
https://pubmed.ncbi.nlm.nih.gov/30023395
https://pubmed.ncbi.nlm.nih.gov/30023395
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 8:719-727
Numerous studies implicate the prolyl peptidase, fibroblast activation protein (FAP) in tumorigenesis; however, FAP-selective inhibitors have not yet been developed to fully validate FAP as a therapeutic target. Herein, we review recent efforts aimed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa183b5f7e90eb0cc3aa0299efda64d6
https://doi.org/10.2174/138955708784567449
https://doi.org/10.2174/138955708784567449
Autor:
Mark Mayeda, Clifford Quan, Christian Wiesmann, Dan Sutherlin, Conrad Yap Edosada, Beni Wolf, Thuy Tran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1438-1442
The structure-activity relationship of various N-acyl-Gly-, N-acyl-Sar-, and N-blocked-boroPro derivatives against three prolyl peptidases was explored. Several N-acyl-Gly- and N-blocked-boroPro compounds showed low nanomolar inhibitory activity agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f8b79d8c908e6d3e742966ec4de48d
https://doi.org/10.1016/j.bmcl.2006.11.072
https://doi.org/10.1016/j.bmcl.2006.11.072
Autor:
Christian Wiesmann, Thuy Tran, Wayne J. Fairbrother, J. Michael Elliott, Helga Raab, Conrad Yap Edosada, Mark Reynolds, Beni Wolf, Dan Sutherlin, Clifford Quan
Publikováno v:
Journal of Biological Chemistry. 281:7437-7444
Fibroblast activation protein (FAP) is a transmembrane serine peptidase that belongs to the prolyl peptidase family. FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd10fd146b416431ccf4aae85fffe11a
https://doi.org/10.1074/jbc.m511112200
https://doi.org/10.1074/jbc.m511112200