Zobrazeno 1 - 10
of 296
pro vyhledávání: '"Bengt Westermark"'
Autor:
Rajesh Kumar Gupta, Mia Niklasson, Tobias Bergström, Anna Segerman, Christer Betsholtz, Bengt Westermark
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The migration of neural progenitor cells (NPCs) to their final destination during development follows well-defined pathways, such as along blood vessels. Cells originating from the highly malignant tumor glioblastoma (GBM) seem to exploit si
Externí odkaz:
https://doaj.org/article/f97712fb396c46efa5c0486cc8f6fc6b
Autor:
Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, Bengt Westermark, Carl‐Henrik Heldin
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Glioma‐initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum‐free conditions. Bone morphogenetic prot
Externí odkaz:
https://doaj.org/article/f4c4a73f1b084baab8b336259bb1ce03
Autor:
Ida Larsson, Erika Dalmo, Ramy Elgendy, Mia Niklasson, Milena Doroszko, Anna Segerman, Rebecka Jörnsten, Bengt Westermark, Sven Nelander
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 9, Pp n/a-n/a (2021)
Abstract Tumor cell heterogeneity is a crucial characteristic of malignant brain tumors and underpins phenomena such as therapy resistance and tumor recurrence. Advances in single‐cell analysis have enabled the delineation of distinct cellular stat
Externí odkaz:
https://doaj.org/article/65c2adc5f7ff4fcfb10d205bdc3d16b7
Autor:
Ioannis Kaffes, Frank Szulzewsky, Zhihong Chen, Cameron J. Herting, Ben Gabanic, José E. Velázquez Vega, Jennifer Shelton, Jeffrey M. Switchenko, James L. Ross, Leon F. McSwain, Jason T. Huse, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom, Naga Prathyusha Maturi, Patrick. J. Cimino, Eric C. Holland, Helmut Kettenmann, Cameron W. Brennan, Daniel J. Brat, Dolores Hambardzumyan
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding of pathogenetic mechanisms
Externí odkaz:
https://doaj.org/article/99915def14e347129ecc08b39b7bf014
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Objectives Although CpG methylation is well studied, mechanisms of non-CpG methylation in mammals remains elusive. Studying proteins with non-CpG cytosine methylation-sensitive DNA-binding, such as human CGGBP1, can unveil cytosine methylati
Externí odkaz:
https://doaj.org/article/f29d7c33c7c94bb3a92316c5a6589c7e
Autor:
Spyros Darmanis, Caroline Julie Gallant, Voichita Dana Marinescu, Mia Niklasson, Anna Segerman, Georgios Flamourakis, Simon Fredriksson, Erika Assarsson, Martin Lundberg, Sven Nelander, Bengt Westermark, Ulf Landegren
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 380-389 (2016)
Significant advances have been made in methods to analyze genomes and transcriptomes of single cells, but to fully define cell states, proteins must also be accessed as central actors defining a cell’s phenotype. Methods currently used to analyze e
Externí odkaz:
https://doaj.org/article/07ef05bb509d4787ba3a9b5efe3e0652
Autor:
Yuan Xie, Tobias Bergström, Yiwen Jiang, Patrik Johansson, Voichita Dana Marinescu, Nanna Lindberg, Anna Segerman, Grzegorz Wicher, Mia Niklasson, Sathishkumar Baskaran, Smitha Sreedharan, Isabelle Everlien, Marianne Kastemar, Annika Hermansson, Lioudmila Elfineh, Sylwia Libard, Eric Charles Holland, Göran Hesselager, Irina Alafuzoff, Bengt Westermark, Sven Nelander, Karin Forsberg-Nilsson, Lene Uhrbom
Publikováno v:
EBioMedicine, Vol 2, Iss 10, Pp 1351-1363 (2015)
Glioblastoma (GBM) is the most frequent and malignant form of primary brain tumor. GBM is essentially incurable and its resistance to therapy is attributed to a subpopulation of cells called glioma stem cells (GSCs). To meet the present shortage of r
Externí odkaz:
https://doaj.org/article/75556f6c5fd94fbea5d121e6ecd740bb
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 6, Pp 492-503 (2011)
According to the cancer stem cell (CSC)/cancer-initiating cell hypothesis, glioma development is driven by a subpopulation of cells with unique tumor-regenerating capacity. We have characterized sphere-cultured glioma-derived cancer-initiating cells
Externí odkaz:
https://doaj.org/article/9bd694dbb63042c78ece569a1741d39c
Autor:
Shimei Wee, Maria Niklasson, Voichita Dana Marinescu, Anna Segerman, Linnéa Schmidt, Annika Hermansson, Peter Dirks, Karin Forsberg-Nilsson, Bengt Westermark, Lene Uhrbom, Sten Linnarsson, Sven Nelander, Michael Andäng
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115698 (2014)
Tumor-initiating cells are a subpopulation in aggressive cancers that exhibit traits shared with stem cells, including the ability to self-renew and differentiate, commonly referred to as stemness. In addition, such cells are resistant to chemo- and
Externí odkaz:
https://doaj.org/article/d40d7ec5b66645cea8c9dd221bf34140
Autor:
Di Yu, Chuan Jin, Mohanraj Ramachandran, Jing Xu, Berith Nilsson, Olle Korsgren, Katarina Le Blanc, Lene Uhrbom, Karin Forsberg-Nilsson, Bengt Westermark, Rachel Adamson, Norman Maitland, Xiaolong Fan, Magnus Essand
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54952 (2013)
Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for effi
Externí odkaz:
https://doaj.org/article/81845b54f6f045ed86a4443cbfdc2970