Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Bengt Fadeel"'
Autor:
Giusy del Giudice, Angela Serra, Alisa Pavel, Marcella Torres Maia, Laura Aliisa Saarimäki, Michele Fratello, Antonio Federico, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Hazard assessment is the first step in evaluating the potential adverse effects of chemicals. Traditionally, toxicological assessment has focused on the exposure, overlooking the impact of the exposed system on the observed toxicity. However
Externí odkaz:
https://doaj.org/article/3113aa82df4d44aaa47e36e21619b12f
Autor:
Bengt Fadeel, Phil Sayre
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Bengt Fadeel and Phil Sayre discuss lessons learned with respect to the safety assessment of nanomaterials, and provide a perspective on current and future challenges.
Externí odkaz:
https://doaj.org/article/0afdc4e74edc4d07a04ae66d82ad49e8
Autor:
Vittorio Fortino, Pia Anneli Sofia Kinaret, Michele Fratello, Angela Serra, Laura Aliisa Saarimäki, Audrey Gallud, Govind Gupta, Gerard Vales, Manuel Correia, Omid Rasool, Jimmy Ytterberg, Marco Monopoli, Tiina Skoog, Peter Ritchie, Sergio Moya, Socorro Vázquez-Campos, Richard Handy, Roland Grafström, Lang Tran, Roman Zubarev, Riitta Lahesmaa, Kenneth Dawson, Katrin Loeschner, Erik Husfeldt Larsen, Fritz Krombach, Hannu Norppa, Juha Kere, Kai Savolainen, Harri Alenius, Bengt Fadeel, Dario Greco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Nanomaterials have a range of potential applications, however, toxicity remains a concern, limiting application and requiring extensive testing. Here, the authors report on a predictive framework made using a range of tests linking materials properti
Externí odkaz:
https://doaj.org/article/cd868a81e9ec4d95b4b5c073cf9197e3
Autor:
Govind Gupta, Francesca Cappellini, Lucian Farcal, Rosalba Gornati, Giovanni Bernardini, Bengt Fadeel
Publikováno v:
Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-27 (2022)
Abstract Background Copper oxide (CuO) nanoparticles (NPs) are known to trigger cytotoxicity in a variety of cell models, but the mechanism of cell death remains unknown. Here we addressed the mechanism of cytotoxicity in macrophages exposed to CuO N
Externí odkaz:
https://doaj.org/article/dfb677f022a44499a87ea92d7d31d633
Autor:
Maelle Fontaine, Eline Bartolami, Marion Prono, David Béal, Magda Blosi, Anna L Costa, Costanza Ravagli, Giovanni Baldi, Simone Sprio, Anna Tampieri, Ivana Fenoglio, Lang Tran, Bengt Fadeel, Marie Carriere
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0288737 (2023)
Toxicity evaluation of engineered nanomaterials is challenging due to the ever increasing number of materials and because nanomaterials (NMs) frequently interfere with commonly used assays. Hence, there is a need for robust, high-throughput assays wi
Externí odkaz:
https://doaj.org/article/9fa7423a03d8473ea7975bc35445f649
Autor:
Govind Gupta, Bejan Hamawandi, Daniel J. Sheward, Ben Murrell, Leo Hanke, Gerald McInerney, Magda Blosi, Anna L. Costa, Muhammet S. Toprak, Bengt Fadeel
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Silver (Ag) is known to possess antimicrobial properties which is commonly attributed to soluble Ag ions. Here, we showed that Ag nanoparticles (NPs) potently inhibited SARS-CoV-2 infection using two different pseudovirus neutralization assays. We al
Externí odkaz:
https://doaj.org/article/34bdef8931f2467c8306a18b712c1714
Autor:
Sebastin Martin, Laura de Haan, Ignacio Miro Estruch, Kai Moritz Eder, Anne Marzi, Jürgen Schnekenburger, Magda Blosi, Anna Costa, Giulia Antonello, Enrico Bergamaschi, Chiara Riganti, David Beal, Marie Carrière, Olivier Taché, Gary Hutchison, Eva Malone, Lesley Young, Luisa Campagnolo, Fabio La Civita, Antonio Pietroiusti, Stéphanie Devineau, Armelle Baeza, Sonja Boland, Cai Zong, Gaku Ichihara, Bengt Fadeel, Hans Bouwmeester
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes which are controlled by the nuclear erythroid 2-related factor 2 (NRF2) tra
Externí odkaz:
https://doaj.org/article/876fc2f332f3486997b6cd6f1f9c0aa0
Autor:
Esperanza Padín-González, Pearl Lancaster, Massimo Bottini, Paolo Gasco, Lang Tran, Bengt Fadeel, Terence Wilkins, Marco P. Monopoli
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Poly (ethylene glycol) (PEG) is a widely used polymer in a variety of consumer products and in medicine. PEGylation refers to the conjugation of PEG to drugs or nanoparticles to increase circulation time and reduce unwanted host responses. PEG is vie
Externí odkaz:
https://doaj.org/article/c8db24da3482498fb7b1c1d18196cd95
Autor:
Thanpisit Lomphithak, Selin Helvacioglu, Ilaria Armenia, Sandeep Keshavan, Jesús G. Ovejero, Giovanni Baldi, Costanza Ravagli, Valeria Grazú, Bengt Fadeel
Publikováno v:
Nanomaterials, Vol 13, Iss 11, p 1719 (2023)
Ferroptosis, a form of iron-dependent, lipid peroxidation-driven cell death, has been extensively investigated in recent years, and several studies have suggested that the ferroptosis-inducing properties of iron-containing nanomaterials could be harn
Externí odkaz:
https://doaj.org/article/472d912aaf054f5a9e00b565ca16f6c4
Publikováno v:
Frontiers in Toxicology, Vol 3 (2021)
Most cell culture models are static, but the cellular microenvironment in the body is dynamic. Here, we established a microfluidic-based in vitro model of human bronchial epithelial cells in which cells are stationary, but nutrient supply is dynamic,
Externí odkaz:
https://doaj.org/article/504298ef451c4a77b36d7119b79a0d21