Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine

Autor: Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy

Publikováno v: Cell Reports, Vol 36, Iss 6, Pp 109498- (2021)

Externí odkaz: https://doaj.org/article/f266ff945e92477783e50248e2c7ba7a

Characterization of novel and uncharacterized p53 SNPs in the Chinese population--intron 2 SNP co-segregates with the common codon 72 polymorphism.

Autor: Beng Hooi Phang, Hui Wan Chua, Huihua Li, Yeh Ching Linn, Kanaga Sabapathy

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e15320 (2011)

Multiple single nucleotide polymorphisms (SNPs) have been identified in the tumor suppressor gene p53, though the relevance of many of them is unclear. Some of them are also differentially distributed in various ethnic populations, suggesting selecti

Externí odkaz: https://doaj.org/article/176d681387e5477d9c37a364d0e5f10c

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine

Autor: Rashidah Othman, Jabed Iqbal, Xin Yu Koh, A. Mark Richards, Kanaga Sabapathy, Le-Ann Hwang, Xiao Hui Koh, Yuezhen Xue, David P. Lane, Beng Hooi Phang, Oi Wah Liew

Publikováno v: Cell Reports, Vol 22, Iss 1, Pp 299-312 (2018)
Cell Reports, Vol 36, Iss 6, Pp 109498-(2021)

Summary: The large number of mutations identified across all cancers represents an untapped reservoir of targets that can be useful for therapeutic targeting if highly selective, mutation-specific reagents are available. We report here our attempt to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4caa780c4e4bb9fd49e14f85aecac4df
https://pubmed.ncbi.nlm.nih.gov/34380044

Longitudinal metabolic imaging of hepatocellular carcinoma in transgenic mouse models identifies acylcarnitine as a potential biomarker for early detection

Autor: Venkatesh Gopalan, Rashidah Othman, Han Chong Toh, Who Whong Wang, Sanjay Kumar Verma, Kanaga Sabapathy, S. Sendhil Velan, Wei Wei Teoh, Beng Hooi Phang, Jadegoud Yaligar, Swee Shean Lee

Publikováno v: Scientific Reports

The cumulative effects of hepatic injury due to hepatitis B virus (HBV) infections and aflatoxin-B1 (AFB1) exposure are the major risk factors of HCC. Understanding early metabolic changes involving these risk factors in an animal model closely resem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296fc68bb80a9fe0adc5d25c97d72ee7
https://doi.org/10.1038/srep20299

Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis

Autor: Gaëlle Bougeard, Ren Hui Chia, Peh Yean Cheah, Kanaga Sabapathy, Choong Leong Tang, Beng Hooi Phang, Rashidah Othman, Thierry Frebourg

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2015, 112 (46), pp.E6349-E6358. ⟨10.1073/pnas.1510043112⟩

Whereas most mutations in p53 occur in the DNA-binding domain and lead to its functional inactivation, their relevance in the amino-terminal transactivation domain is unclear. We show here that amino-terminal p53 (ATp53) mutations often result in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507304d7272ab6e98a6f677663eed494
https://hal-normandie-univ.archives-ouvertes.fr/hal-02356393