Výsledky vyhledávání - "Beng H, Chong"

Akademický článek

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

Autor: Halina H. L. Leung, Jose Perdomo, Zohra Ahmadi, Shiying S. Zheng, Fairooj N. Rashid, Anoop Enjeti, Stephen B. Ting, James J. H. Chong, Beng H. Chong

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

The mechanisms underlying the pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT) remain unclear. Here the authors show that anti-PF4 antibodies are responsible for the activation of platelets and neutrophils, and blockage of Fc

Externí odkaz: https://doaj.org/article/bc08ff0fc12b4e0fb1c3362d3856f4bc

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Akademický článek

Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice

Publikováno v: JCI Insight, Vol 7, Iss 2 (2022)

Platelet-neutrophil aggregates (PNAs) facilitate neutrophil activation and migration and could underpin the recruitment of neutrophils to the pancreas during type 1 diabetes (T1D) pathogenesis. PNAs, measured by flow cytometry, were significantly ele

Externí odkaz: https://doaj.org/article/6ed7806b9e764fde908116c406bf2ddb

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Akademický článek

Updated international consensus report on the investigation and management of primary immune thrombocytopenia

Publikováno v: Blood Advances, Vol 3, Iss 22, Pp 3780-3817 (2019)

Abstract: Over the last decade, there have been numerous developments and changes in treatment practices for the management of patients with immune thrombocytopenia (ITP). This article is an update of the International Consensus Report published in 2

Externí odkaz: https://doaj.org/article/615595aac465412eafebf2c7540a0966

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Akademický článek

Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia

Autor: José Perdomo, Halina H. L. Leung, Zohra Ahmadi, Feng Yan, James J. H. Chong, Freda H. Passam, Beng H. Chong

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

The pathogenesis of heparin-induced thrombocytopenia and thrombosis (HIT) is mediated by heparin-reactive autoantibodies binding to platelets (thrombocytes). Here the authors show neutrophil activation and NETosis are elevated in patients with HIT, a

Externí odkaz: https://doaj.org/article/15928141dfc447cb9a207a9ee46269e1

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Akademický článek

Drug-induced immune thrombocytopenia: Mapping of the drug binding site to the membrane-proximal region of platelet GPIX

Autor: Zohra Ahmadi, Jose Perdomo, Rose Wong, Beng H Chong

Publikováno v: Platelets, Vol 30, Iss 2, Pp 251-255 (2019)

Drug-induced Immune thrombocytopenia (DIT) is a common complication of several medications, including commonly used antibiotics. The most widely studied DIT is caused by quinine. In DIT, antibodies predominantly bind to the platelet membrane glycopro

Externí odkaz: https://doaj.org/article/f265d54df2814844a5f88a5a83dd156b

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