Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Benfeard Williams"'
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 10, p e1004359 (2015)
The increased risk of developing Alzheimer's disease (AD) is associated with the APOE gene, which encodes for three variants of Apolipoprotein E, namely E2, E3, E4, differing only by two amino acids at positions 112 and 158. ApoE4 is known to be the
Externí odkaz:
https://doaj.org/article/29a98153fc594ce3b7718d2a26055b23
Autor:
Jian Wang, Rajeshree Das, Venkata R Chirasani, Nikolay V. Dokholyan, Benfeard Williams, Andrey Krokhotin
Publikováno v:
Nucleic Acids Research
RNA structural complexity and flexibility present a challenge for computational modeling efforts. Experimental information and bioinformatics data can be used as restraints to improve the accuracy of RNA tertiary structure prediction. Regarding utili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717e2b93196917588fd222ab005fa037
https://doi.org/10.1093/nar/gkz427
https://doi.org/10.1093/nar/gkz427
Autor:
Chanin Tolson Woods, Benfeard Williams, Nikolay V. Dokholyan, David Gotz, Lela Lackey, Alain Laederach
Publikováno v:
Biophysical Journal
When a ribonucleic acid (RNA) molecule folds, it often does not adopt a single, well-defined conformation. The folding energy landscape of an RNA is highly dependent on its nucleotide sequence and molecular environment. Cellular molecules sometimes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd1ede4f18b0194f1c560e62b506223
http://europepmc.org/articles/PMC5529173
http://europepmc.org/articles/PMC5529173
Autor:
Timothy M. Jacobs, J. F. Federizon, Benfeard Williams, X. Xu, Tishan Williams, Thomas Szyperski, Alexander Eletsky, Brian Kuhlman
Publikováno v:
Science. 352:687-690
Building new proteins from the old Proteins are the workhorses of biology. Designing new, stable proteins with functions desirable in biotechnology or biomedicine remains challenging. Jacobs et al. developed a computational method called SEWING that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2cb0606ea44ea2c8745e3fd835749e
https://doi.org/10.1126/science.aad8036
https://doi.org/10.1126/science.aad8036
Autor:
Yuri L. Lyubchenko, Benfeard Williams, Yuliang Zhang, Konstantin I. Popov, Mohtadin Hashemi, Zhengjian Lv, Nikolay V. Dokholyan
α-Synuclein (α-syn) is the major component of the intraneuronal inclusions called Lewy bodies, which are the pathological hallmark of Parkinson's disease. α-Syn is capable of self-assembly into many different species, such as soluble oligomers and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c3de6bde1885da5930c6a11c967c4a
https://europepmc.org/articles/PMC5764752/
https://europepmc.org/articles/PMC5764752/
The apolipoprotein E4 (ApoE4) gene is the strongest genetic risk factor for Alzheimer's disease (AD). With respect to the other common isoforms of this protein (ApoE2 and ApoE3), ApoE4 is characterized by lower stability that underlies the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46550a337295d7506d9c2992e4b5830
https://europepmc.org/articles/PMC5700245/
https://europepmc.org/articles/PMC5700245/
Autor:
Greggory M. Rice, Dong Zhang, Yi Xiao, François Major, Joseph A. Piccirilli, Thomas H. Mann, Fang-Chieh Chou, Marcin Biesiada, Clarence Yu Cheng, Feng Ding, Arpit Tandon, Dinshaw J. Patel, Kevin M. Weeks, Alexander J. Becka, Joanna Sarzynska, John SantaLucia, Ryszard W. Adamiak, Kalli Kappel, Rhiju Das, Wipapat Kladwang, Zhichao Miao, Michal J. Boniecki, Robert T. Batey, Katarzyna J. Purzycka, Tomasz Zok, Caleb Geniesse, Aiming Ren, Wayne K. Dawson, Maciej Antczak, Janusz M. Bujnicki, Shi-Jie Chen, Andrey Krokhotin, Jian Wang, Katarzyna Pachulska-Wieczorek, Siqi Tian, Nikolay V. Dokholyan, Xiaojun Xu, Marcin Magnus, Grzegorz Łach, Marta Szachniuk, Stanislaw Dunin-Horkawicz, Jeremiah J. Trausch, Eric Westhof, Benfeard Williams, Mariusz Popenda, Adrian R. Ferré-D'Amaré
Publikováno v:
RNA
RNA, Cold Spring Harbor Laboratory Press, 2017, 23 (5), pp.655-672. ⟨10.1261/rna.060368.116⟩
RNA, Cold Spring Harbor Laboratory Press, 2017, 23 (5), pp.655-672. ⟨10.1261/rna.060368.116⟩
RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report here a third round of RNA-Puzzles. Five puzzles, 4, 8, 12, 13, 14, all structures of riboswitch aptamers and puzzle 7, a ribozyme structure, are included in this r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02529620f2174f01acae09e88a752f7
https://hal.archives-ouvertes.fr/hal-02171291
https://hal.archives-ouvertes.fr/hal-02171291
Publikováno v:
Nature chemical biology
The use of chemical exchange saturation transfer NMR reveals a previously hidden excited conformational state of the fluoride riboswitch, providing a model in which ligand binding allosterically suppresses a linchpin base pair to activate transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105c57073adc7f7b825d31b7ff78c1dc
https://pubmed.ncbi.nlm.nih.gov/28719589
https://pubmed.ncbi.nlm.nih.gov/28719589
Autor:
Feng Ding, Qi Zhang, Bo Zhao, Arpit Tandon, Kevin M. Weeks, Nikolay V. Dokholyan, Benfeard Williams
Publikováno v:
Nucleic Acids Research
RNAs fold into distinct molecular conformations that are often essential for their functions. Accurate structure modeling of complex RNA motifs, including ubiquitous non-canonical base pairs and pseudoknots, remains a challenge. Here, we present an N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037946ea16248606134843cfc1c18102
Publikováno v:
Alzheimer's & Dementia. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64bdcb3991d2e15d743590b251202085
https://doi.org/10.1016/j.jalz.2016.06.1273
https://doi.org/10.1016/j.jalz.2016.06.1273